Promethean Evolution: A Comparison of the Immune and Neural Systems

Perspectives in Biology and Medicine 57 (4):449-469 (2014)
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Abstract

…behind the diversity of discoveries [in molecular biology] moved a unity, a constant direction of change, the development of the concept of biological specificity.In his landmark book Evolution by Gene Duplication, geneticist Susumu Ohno pointed out that whereas most evolutionary developments represent adjustments to past challenges and mutations, two unique systems had evolved to deal with future challenges: the immune response and neural memory functions. He named these two evolutionary modes after the Titan brothers of Greek mythology: “standard” evolutionary developments were named for rearward-looking Epimetheus, and “anticipatory” evolutionary mechanisms for foresighted Prometheus (Ohno 1976; Ohno et..

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