Cyclic nucleotides as regulators of light-adaptation in photoreceptors

Behavioral and Brain Sciences 18 (3):493-494 (1995)

Cyclic nucleotides can regulate the sensitivity of retinal rods to light through phosducin. The phosphorylation state of phosducin determines the amount of G available for activation by Rho*. Phosducin phosphorylation is regulated by cyclic nucleotides through their activation of cAMP-dependent protein kinase. The regulation of phosphodiesterase activity by the noncatalytic cGMP binding sites as well as Ca2+/calmodulin dependent regulation of cGMP binding to the cation channel are also discussed
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DOI 10.1017/S0140525X00039510
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