The Ethics of Rapid Tissue Donation (Rtd): Constructing a Formal and Substantial Informed Consent Process

Springer Verlag (2021)
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Abstract

This book offers a reflection on the central role that the ethics of informed consent plays in Rapid Tissue Donation. RTD is an advanced oncology procedure that involves the procurement, for research purposes, of “fresh” tissues within two to six hours of a cancer patient’s death. Since RTD involves the retrieval of tissues after death, and since the collected tissues are of great importance for medical research, the need for any form of informed consent to regulate this procedure has been questioned. This book argues for the necessity of informed consent to govern RTD, and it provides the reader with a bespoke informed consent process applicable to cancer patients. The analysis unfolds at the intersection between applied ethics, public health ethics, and clinical ethics, and it is informed by philosophical theories of informed consent and by the social implications of individual choices. By viewing medical issues relating to informed consent in oncology from an ethical perspective, the book combines philosophical analysis with discussion of concrete cancer-related issues. As a result, the book is suitable for readers interested in ethical reasoning as well as for those with a medical background. It contributes to contemporary research by offering an original analysis that relies on a rigorous philosophical approach to address innovative issues at the cutting edge of medical research and policy making.

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Chapters

Informed Consent for RTD: An Overview

This chapter sets out an informed consent process, in both the formal and the substantial senses of that term, for the innovative technique of Rapid Tissue Donation . The analysis focuses on practical aspects that have relevant clinical ethics implications, such as choosing the right timing for the ... see more

Rapid Tissue Donation for Oncology Research

Research in genomics and “omics” technologies is making possible “precision medicine”, a targeted approach to the diagnosis and treatment of diseases. The goal of precision medicine, and one that holds great promise in oncology, is to treat patients with drugs that target the specific genetic mutati... see more

An Informed Consent for RTD? the Ethics of Postmortem Procedures

This chapter broadens the discussion of informed consent by considering biomedical ethics more generally. First, it presents Beauchamp and Childress’s analysis of the four principles of autonomy, beneficence, non-maleficence, and justice, which constitute the basis of biomedical ethics reflection. T... see more

Informed Consent for RTD: A Closer Look at Ethical Issues

Drawing on the structure of the informed consent process provided in Chapter 7, this chapter explores the ethical issues that arise from Rapid Tissue Donation decision-making. Guided by altruism, RTD represents a special agreement between cancer patients and science, which is regulated by respect an... see more

Informed Consent and Research

This chapter discusses the importance of informed consent for research. It opens by focusing on the difference between research and care, the acknowledgement and appreciation of which is crucial for the informed consent process. An overview of regulations concerning the ethical conduct of research i... see more

An Informed Consent for RTD? Honoring the Wishes of the Once-Alive

Following on from the discussion in the previous chapter about whether there is a need for an informed consent to Rapid Tissue Donation , this chapter claims that an informed consent procedure is necessary. Rejecting Steiner’s arguments about the deceased status, the analysis employs the concept of ... see more

Two Senses of Informed Consent

This chapter introduces the evolution of the relationship between patients and physicians as well as implications for informed consent. It then focuses on the two meanings of informed consent: the substantial sense and the formal sense. In doing so, it subjects the notion of informed consent to a ph... see more

The Clinical Ethicist

Advances in biotechnology and medicine invariably have ethical implications. New approaches to healthcare and treatment options are now possible, but they are accompanied by unprecedented ethical and clinical questions that require thorough analysis. These issues involve extremely delicate areas at ... see more

Rapid Tissue Donation (RTD) for Oncology Research

Research in genomics and “omics” technologies is making possible “precision medicine”, a targeted approach to the diagnosis and treatment of diseases. The goal of precision medicine, and one that holds great promise in oncology, is to treat patients with drugs that target the specific genetic mutati... see more

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