Journal of the History of Biology 33 (3):535-576 (2000)

Abstract
Much of the early history of developmental and physiological genetics in Germany remains to be written. Together with Carl Correns and Richard Goldschmidt, Alfred Kühn occupies a special place in this history. Trained as a zoologist in Freiburg im Breisgau, he set out to integrate physiology, development and genetics in a particular experimental system based on the flour moth Ephestia kühniella Zeller. This paper is meant to reconstruct the crucial steps in the experimental pathway that led Kühn and his collaborators at the University of Göttingen, and later at the Kaiser Wilhelm Institutes of Biology and Biochemistry in Berlin, to formulate, in their specific way, what later became known as the "one gene-one enzyme hypothesis." Special attention will be given to the interaction of the different parts of Kühn's Ephestia-based project, which were rooted in different research traditions. The paper retraces how, roughly between 1925 and 1945, these elements came to form a mixed experimental setup composed of genetic, embryological, physiological and, finally, biochemical constituents. Accordingly, emphasis is laid on the development of the terminology in which the results were cast, and how it reflected the hybrid state of an experimental system successively acquiring new epistemic layers
Keywords Alfred Kühn  Ernst Caspari   Ephestia kühniella  physiological developmental genetics  one gene – one enzyme hypothesis  gene action chains  eye pigment formation  tissue transplantation
Categories (categorize this paper)
DOI 10.1023/A:1004858314375
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

Our Archive


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 50,100
Through your library

References found in this work BETA

No references found.

Add more references

Citations of this work BETA

The Varied Lives of Organisms: Variation in the Historiography of the Biological Sciences.Gerald L. Geison & Manfred D. Laubichler - 2001 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 32 (1):1-29.
Stages in the Development of a Model Organism as a Platform for Mechanistic Models in Developmental Biology: Zebrafish, 1970–2000.Robert Meunier - 2012 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 43 (2):522-531.
The Varied Lives of Organisms: Variation in the Historiography of the Biological Sciences.Gerald L. Geison & Manfred D. Laubichler - 2001 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 32 (1):1-29.
Muriel Wheldale Onslow and Early Biochemical Genetics.Marsha L. Richmond - 2007 - Journal of the History of Biology 40 (3):389 - 426.

View all 10 citations / Add more citations

Similar books and articles

Experimentation Versus Theory Choice: A Social-Epistemological Approach.Marcel Weber - 2011 - In Hans Bernhard Schmid, Daniel Sirtes & Marcel Weber (eds.), Collective Epistemology. Ontos. pp. 20--203.
The Pen and the Sword: Recovering the Disciplinary Identity of Physiology and Anatomy Before 1800 - I: Old Physiology-the Pen.A. Cunningham - 2002 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 33 (4):631-665.
Recovering Thomas Kuhn.Joseph Rouse - 2013 - Topoi 32 (1):59-64.
Evidence and Experimental Design in Sequential Trials.Jan Sprenger - 2009 - Philosophy of Science 76 (5):637-649.

Analytics

Added to PP index
2011-05-29

Total views
28 ( #345,704 of 2,324,383 )

Recent downloads (6 months)
2 ( #466,264 of 2,324,383 )

How can I increase my downloads?

Downloads

My notes