Results for 'PKM2'

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    The Warburg effect then and now: From cancer to inflammatory diseases.Eva M. Palsson‐McDermott & Luke Aj O'neill - 2013 - Bioessays 35 (11):965-973.
    Inflammatory immune cells, when activated, display much the same metabolic profile as a glycolytic tumor cell. This involves a shift in metabolism away from oxidative phosphorylation towards aerobic glycolysis, a phenomenon known as the Warburg effect. The result of this change in macrophages is to rapidly provide ATP and metabolic intermediates for the biosynthesis of immune and inflammatory proteins. In addition, a rise in certain tricarboxylic acid cycle intermediates occurs notably in citrate for lipid biosynthesis, and succinate, which activates the (...)
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