Just when molecular biology is arguably delivering on some of its long‐promised medical applications—think mRNA vaccines, monoclonal antibody drugs, PCR testing, and gene therapies—the history of molecular biology has lost much of its shine. What not too long ago seemed like a burgeoning field of research with endless possibilities, is now often reduced to the “central dogma” that saw its apotheosis in the effort to sequence the human genome but has since unraveled. The essay will discuss several possible answers to (...) this apparent paradox. (shrink)

Berichte zur Wissenschaftsgeschichte, Volume 45, Issue 3, Page 462-467, September 2022.

This essay considers how scholarly approaches to the development of molecular biology have too often narrowed the historical aperture to genes, overlooking the ways in which other objects and processes contributed to the molecularization of life. From structural and dynamic studies of biomolecules to cellular membranes and organelles to metabolism and nutrition, new work by historians, philosophers, and STS scholars of the life sciences has revitalized older issues, such as the relationship of life to matter, or of physicochemical inquiries to (...) biology. This scholarship points to a novel molecular vista that opens up a pluralist view of molecularizations in the twentieth century and considers their relevance to current science. (shrink)