Switch to: References

Add citations

You must login to add citations.
  1. Stress‐induced cellular adaptive strategies: Ancient evolutionarily conserved programs as new anticancer therapeutic targets.Arcadi Cipponi & David M. Thomas - 2014 - Bioessays 36 (6):552-560.
    Despite the remarkable achievements of novel targeted anti‐cancer drugs, most therapies only produce remission for a limited time, resistance to treatment, and relapse, often being the ultimate outcome. Drug resistance is due to highly efficient adaptive strategies utilized by cancer cells. Exogenous and endogenous stress stimuli are known to induce first‐line responses, capable of re‐establishing cellular homeostasis and determining cell fate decisions. Cancer cells may also mount second‐line adaptive strategies, such as the mutator response. Hypermutable subpopulations of cells may expand (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   6 citations  
  • Host manipulation by cancer cells: Expectations, facts, and therapeutic implications.Tazzio Tissot, Audrey Arnal, Camille Jacqueline, Robert Poulin, Thierry Lefèvre, Frédéric Mery, François Renaud, Benjamin Roche, François Massol, Michel Salzet, Paul Ewald, Aurélie Tasiemski, Beata Ujvari & Frédéric Thomas - 2016 - Bioessays 38 (3):276-285.
    Similar to parasites, cancer cells depend on their hosts for sustenance, proliferation and reproduction, exploiting the hosts for energy and resources, and thereby impairing their health and fitness. Because of this lifestyle similarity, it is predicted that cancer cells could, like numerous parasitic organisms, evolve the capacity to manipulate the phenotype of their hosts to increase their own fitness. We claim that the extent of this phenomenon and its therapeutic implications are, however, underappreciated. Here, we review and discuss what can (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  • Can a minimal replicating construct be identified as the embodiment of cancer?Ricard V. Solé, Sergi Valverde, Carlos Rodriguez-Caso & Josep Sardanyés - 2014 - Bioessays 36 (5):503-512.
    Genomic instability is a hallmark of cancer. Cancer cells that exhibit abnormal chromosomes are characteristic of most advanced tumours, despite the potential threat represented by accumulated genetic damage. Carcinogenesis involves a loss of key components of the genetic and signalling molecular networks; hence some authors have suggested that this is part of a trend of cancer cells to behave as simple, minimal replicators. In this study, we explore this conjecture and suggest that, in the case of cancer, genomic instability has (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  • The Computational Boundary of a “Self”: Developmental Bioelectricity Drives Multicellularity and Scale-Free Cognition.Michael Levin - 2019 - Frontiers in Psychology 10.
    All epistemic agents physically consist of parts that must somehow comprise an integrated cognitive self. Biological individuals consist of subunits (organs, cells, molecular networks) that are themselves complex and competent in their own context. How do coherent biological Individuals result from the activity of smaller sub-agents? To understand the evolution and function of metazoan bodies and minds, it is essential to conceptually explore the origin of multicellularity and the scaling of the basal cognition of individual cells into a coherent larger (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   8 citations