David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Brain and Mind 1 (2):155-179 (2000)
Pains that persist long after damaged tissue hasrecovered remain a perplexing phenomenon. Theseso-called chronic pains serve no useful function foran organism and, given its disabling effects, mighteven be considered maladaptive. However, a remarkablesimilarity exists between the neural bases thatunderlie the hallmark symptoms of chronic pain andthose that subserve learning and memory. Bothphenomena, wind-up in the pain literature andlong-term potentiation (LTP) in the learning andmemory literature, are forms of neuroplasticity inwhich increased neural activity leads to a longlasting increase in the excitability of neuronsthrough structural modifications at pre- andpost-synaptic sites. Moreover, the synapticmodifications of wind-up and LTP share a commonmechanism: a glutamate N -methyl-D-aspartate(NMDA) receptor interaction that initiates a calciummediated biochemical cascade that ultimately enhancessignal processing at the -amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor. This paper arguesthat chronic pain, which has no adaptive value, canbe accounted for in terms of the highly adaptivephenomenon of activity-dependent neural plasticity;hence, some cases of chronic pain can beconceptualized as a memory trace in spinal neurons.
|Keywords||acupuncture chronic pain evolutionary psychology long-term potentiation long-term depression neuroplasticity nociception phantom pain TENS wind-up|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Tetsuo Koyama, John G. McHaffie, Paul J. Laurienti & Robert C. Coghill (2005). The Subjective Experience of Pain: Where Expectations Become Reality. Pnas 102 (36):12950-12955.
C. R. Chapman, Y. Nakakura & C. N. Chapman (2000). Pain and Folk Theory. Brain and Mind 1 (2):209-222.
Robert J. Gatchel, Perry N. Fuchs & Colin Allen (2006). 18 Ethical Issues in Chronic Pain Research. In B. L. Gant & M. E. Schatman (eds.), Ethical Issues in Chronic Pain Management. 295.
Misha-Miroslav Backonja (1997). The Neural Basis of Chronic Pain, its Plasticity and Modulation. Behavioral and Brain Sciences 20 (3):435-437.
Paolo Marchettini, Marco Lacerenza & Fabio Formaglio (1997). Experimental Pain Models and Clinical Chronic Pain: Is Plasticity Enough to Link Them? Behavioral and Brain Sciences 20 (3):458-459.
R. J. Gatchel, Colin Allen & P. N. Fuchs (2006). Ethical Issues in Chronic Pain Research. In B. L. Gant & M. E. Schatman (eds.), Ethical Issues in Chronic Pain Management. 295.
Daniel S. Goldberg (2010). Job and the Stigmatization of Chronic Pain. Perspectives in Biology and Medicine 53 (3):425-438.
George Mendelson (1991). Chronic Pain, Compensation and Clinical Knowledge. Theoretical Medicine and Bioethics 12 (3).
Lance M. McCracken (2007). A Contextual Analysis of Attention to Chronic Pain: What the Patient Does with Their Pain Might Be More Important Than Their Awareness or Vigilance Alone. Journal of Pain 8 (3):230-236.
Kenneth J. Sufka & Derek D. Turner (2005). An Evolutionary Account of Chronic Pain: Integrating the Natural Method in Evolutionary Psychology. Philosophical Psychology 18 (2):243-257.
Added to index2009-01-28
Total downloads5 ( #218,427 of 1,096,620 )
Recent downloads (6 months)0
How can I increase my downloads?