The Qur’an and Pancasila are two sources of Indonesian values that are existentially different from each other. Despite the difference, they both factually could walk in harmony, and it is important to seek the similarities and differences between them. This article presents the systematic, substantive, and functional reasons for how they could work altogether by looking at the similarities and differences in anatomy, taxonomy, substance, and function of each component of the Qur’an and Pancasila. Utilizing a naturalistic approach with content (...) analysis genre, the writers collected the data from various documents, including; manuscripts of the Qur’an, Pancasila, speeches of the founding fathers of Indonesia, and the previous research results using document recording sheets. The collected data were analyzed through content analysis techniques and displayed in pictures and tables. The results showed: (1) the anatomy of the Qur’an consists of four components, namely: divinity, law, history, and story, while the anatomy of Pancasila only consists of a law component; (2) the taxonomy of the Qur’an is intersected with one another, while the taxonomy of Pancasila is stratified. The values in all components are generally the same, and the divine value is the primary value. The taxonomy of values in Pancasila is degraded and systemic, with the divine value as the main value / encompassing other values (prima causa); (3) the Qur’an’s substance covers all life dimensions while the dimensions of Pancasila are limited to law. One of the essential points in this section is that Pancasila makes the Qur’an a source of value; (4) the Qur’an is partially or holistically functional while Pancasila is holistically functional. Therefore, componential and substantial, the Qur’an and Pancasila have similarities, while structurally and functionally, they are different. Contribution: The results of this study described a systematic sequence, substantive relationships and functional pattern between the Qur’an and Pancasila. These research findings are expected to reduce misunderstandings among the Indonesian people about the Qur’an and Pancasila. (shrink)