A leg to stand on: Learning creates pain

Behavioral and Brain Sciences 20 (3):441-442 (1997)
Abstract
The persistence of both inflammatory and neuropathic pain can only be explained when learning processes are taken into account in addition to sensitizing mechanisms. Learning processes such as classical and operant conditioning create memories for pain that are based on altered synaptic connections in supraspinal structures and persist without peripheral input. [coderre & katz; dickenson; wiesenfeld-hallin et al.]
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