David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Philosophy of Science 64 (4):278 (1997)
In this paper, I examine an experimental technique, gene targeting, used for establishing genotype/phenotype relationships. Through analyzing a case study, I identify many pitfalls that may lead to false conclusions about these relationships. I argue that some of these pitfalls may seriously affect gene targeting's usefulness for associating phenotypes with genes cataloged by the Human Genome Project. This case also shows the use of gene targeted mice as model systems for studying genotype/phenotype relationships in humans. Moreover, I argue that it reveals the weakness of one attempt to draw conclusions about the biological determination of sexual and aggressive behaviors in humans
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Kim Sterelny, Kelly C. Smith & Michael Dickison (1996). The Extended Replicator. Biology and Philosophy 11 (3):377-403.
Massimo Pigliucci (2010). Genotype–Phenotype Mapping and the End of the ‘Genes as Blueprint’ Metaphor. Philosophical Transactions Royal Society B 365:557–566.
Kai Hahlweg (1981). Progress Through Evolution? An Inquiry Into the Thought of C.H. Waddington. Acta Biotheoretica 30 (2):103-120.
Nicholas Agar (1996). Teleogy and Genes. Biology and Philosophy 11 (3):289-300.
William C. Wimsatt (1980). The Units of Selection and the Structure of the Multi-Level Genome. PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1980:122 - 183.
Brian K. Hall (2003). Unlocking the Black Box Between Genotype and Phenotype: Cell Condensations as Morphogenetic (Modular) Units. [REVIEW] Biology and Philosophy 18 (2):219-247.
Paul E. Griffiths & Karola Stotz (2006). Genes in the Postgenomic Era. Theoretical Medicine and Bioethics 27 (6):499-521.
Kathryn S. Plaisance, Thomas A. C. Reydon & Mehmet Elgin (2012). Why the (Gene) Counting Argument Fails in the Massive Modularity Debate: The Need for Understanding Gene Concepts and Genotype-Phenotype Relationships. Philosophical Psychology 25 (6):873-892.
Degeng Wang (2005). “Molecular Gene”: Interpretation in the Right Context. [REVIEW] Biology and Philosophy 20 (2-3):453-464.
Added to index2009-01-28
Total downloads16 ( #116,578 of 1,410,464 )
Recent downloads (6 months)1 ( #177,872 of 1,410,464 )
How can I increase my downloads?