Philosophy of Science 80 (5):1053-1064 (2013)

Authors
Jan Sprenger
University of Turin
Abstract
Randomized Controlled Trials are currently the gold standard within evidence-based medicine. Usually, they are conducted as sequential trials allowing for monitoring for early signs of effectiveness or harm. However, evidence from early stopped trials is often charged with being biased towards implausibly large effects. To our mind, this skeptical attitude is unfounded and caused by the failure to perform appropriate conditioning in the statistical analysis of the evidence. We contend that a shift from unconditional hypothesis tests in the style of Neyman and Pearson to conditional hypothesis tests gives a superior appreciation of the obtained evidence and significantly improves the practice of sequential medical trials, while staying firmly rooted in frequentist methodology.
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DOI 10.1086/673732
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References found in this work BETA

Evidence in Medicine and Evidence-Based Medicine.John Worrall - 2007 - Philosophy Compass 2 (6):981–1022.
Evidence and Ethics in Medicine.John Worrall - 2008 - Perspectives in Biology and Medicine 51 (3):418-431.
Principles of Inference and Their Consequences.Deborah G. Mayo & Michael Kruse - 2001 - In David Corfield & Jon Williamson (eds.), Foundations of Bayesianism. Kluwer Academic Publishers. pp. 381--403.
Evidence and Experimental Design in Sequential Trials.Jan Sprenger - 2009 - Philosophy of Science 76 (5):637-649.
Monitoring in Clinical Trials: Benefit or Bias?Cecilia Nardini - 2013 - Theoretical Medicine and Bioethics 34 (4):259-274.

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Citations of this work BETA

Monitoring in Clinical Trials: Benefit or Bias?Cecilia Nardini - 2013 - Theoretical Medicine and Bioethics 34 (4):259-274.

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