Comparative and Functional Genomics 6 (7/8):379–387 (2005)

Authors
Barry Smith
State University of New York, Buffalo
Abstract
Tumors, abscesses, cysts, scars, fractures are familiar types of what we shall call pathological continuant entities. The instances of such types exist always in or on anatomical structures, which thereby become transformed into pathological anatomical structures of corresponding types: a fractured tibia, a blistered thumb, a carcinomatous colon. In previous work on biomedical ontologies we showed how the provision of formal definitions for relations such as is_a, part_of and transformation_of can facilitate the integration of such ontologies in ways which have the potential to support new kinds of automated reasoning. We here extend this approach to the treatment of pathologies, focusing especially on those pathological continuant entities which arise when organs become affected by carcinomas.
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References found in this work BETA

Biodynamic Ontology: Applying BFO in the Biomedical Domain.Barry Smith, Pierre Grenon & Louis Goldberg - 2004 - Studies in Health and Technology Informatics 102:20–38.
Pattern as an Ontological Category.Ingvar Johansson - 1998 - In Nicola Guarino (ed.), Formal Ontology in Information Systems. Amsterdam: IOS Press. pp. 86-94.

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