Herpes simplex virus type 2 is the most prevalent sexually transmitted infection in the world, despite the availability of effective anti-viral treatments. A mathematical model to explore the association between gender and HSV-2 treatment adherence is developed. Threshold parameters are determined and stabilities analyzed. Sensitivity analysis of the reproduction number and the numerical simulations suggest that treatment adherence for both females and males are equally important in keeping the reproduction as low as possible. The basic model is then extended to (...) incorporate time-dependent intervention strategies. The Pontryagin’s Maximum Principle is used to characterize the optimal level of the controls, and the resulting optimality system is solved numerically. (shrink)

Herpes simplex virus (HSV)‐derived vectors are currently being developed for the introduction of foreign DNA into neurons. HSV vectors can facilitate a range of molecular studies on postmitotic neurons and may ultimately be used for somatic cell gene therapy for certain neurologic diseases. In this article, the salient features of the pathogenesis and molecular biology of HSV relevant to its use as a vector are described, along with an overview of the methods used to derive these vectors. The accomplishments which (...) have been made to date using the HSV vector system are discussed, with emphasis on the issues of this technology which remain to be addressed. HSV has the potential to be a most useful tool for neuronal cell transgenesis and it is likely that important neurobiological questions will be answered using this vector system. (shrink)

This paper presents an autonomous vision-based obstacle avoidance system. The system consists of three independent vision modules for obstacle detection, each of which is computationally simple and uses a di erent criterion for detection purposes. These criteria are based on brightness gradients, RGB Red, Green, Blue color, and HSV Hue, Saturation, Value color, respectively. Selection of which modules are used to command the robot proceeds exclusively from the outputs of the modules themselves. The system is implemented on a small monocular (...) mobile robot and uses very low resolution images. It has been tested for over 200 hours in diverse environments. Keywords: Vision-based navigation, space exploration, modular design, reactive control, unstructured terrain. (shrink)

Mahoney, Carl Artificial intelligence is so widespread now, and so well embedded into our latest technology, that nearly all of us know it as AI. It is virtually impossible to fully catalogue its uses and applications because by now it has reached every corner of human activities. This is the premise on which I based a lecture to the Humanist Society of Victoria on October 22, 2015 entitled 'The Artificial Intelligence Debate'. The talk was followed by a spirited discussion at (...) a HSV meeting on November 8 chaired by Dr Jennie Mills, who gave an excellent account of the original talk in the Dec. 2015 Victorian Humanist. This article consists of a series of notes following on from the talk and discussion. (shrink)

In this article, we study the mural restoration work based on artificial intelligence-assisted multiscale trace generation. Firstly, we convert the fresco images to colour space to obtain the luminance and chromaticity component images; then we process each component image to enhance the edges of the exfoliated region using high and low hat operations; then we construct a multistructure morphological filter to smooth the noise of the image. Finally, the fused mask image is fused with the original mural to obtain the (...) final calibration result. The fresco is converted to HSV colour space, and chromaticity, saturation, and luminance features are introduced; then the confidence term and data term are used to determine the priority of shedding boundary points; then a new block matching criterion is defined, and the best matching block is obtained to replace the block to be repaired based on the structural similarity between the block to be repaired and the matching block by global search; finally, the restoration result is converted to RGB colour space to obtain the final restoration result. An improved generative adversarial network structure is proposed to address the shortcomings of the existing network structure in mural defect restoration, and the effectiveness of the improved modules of the network is verified. Compared with the existing mural restoration algorithms on the test data experimentally verified, the peak signal-to-noise ratio score is improved by 4% and the structural similarity score is improved by 2%. (shrink)

Positive transcription elongation factor b (P‐TEFb), which comprises cyclin‐dependent kinase 9 (CDK9) kinase and cyclin T subunits, is an essential kinase complex in human cells. Phosphorylation of the negative elongation factors by P‐TEFb is required for productive elongation of transcription of protein‐coding genes by RNA polymerase II (pol II). In addition, P‐TEFb‐mediated phosphorylation of the carboxyl‐terminal domain (CTD) of the largest subunit of pol II mediates the recruitment of transcription and RNA processing factors during the transcription cycle. CDK9 also phosphorylates (...) p53, a tumor suppressor that plays a central role in cellular responses to a range of stress factors. Many viral factors affect transcription by recruiting or modulating the activity of CDK9. In this review, we will focus on how the function of CDK9 is regulated by viral gene products. The central role of CDK9 in viral life cycles suggests that drugs targeting the interaction between viral products and P‐TEFb could be effective anti‐viral agents. (shrink)