At some point in his long career, the eminent physicist J. A. Wheeler (1911-2008), who played a seminal role in framing a remarkable number of the issues that his students and colleagues have been struggling with during the previous decades, started to take Leibniz as an interlocutor sui generis. Up to now, such a confrontation has been hardly appreciated or noticed. In this introductory article, the presence of Leibniz in Wheeler’s thought will be assessed and contextualized within the framework of (...) the issues of physics the latter was meditating upon. This example, as well as the methodology followed in dealing with it properly, should, hopefully, prompt broader considerations at the intersection(s) of the areas involved - mainly, but not only, physics, philosophy, history of science. (shrink)