Are all genes regulatory genes?

Biology and Philosophy 26 (4):595-602 (2011)
Abstract
Although much has been learned about hereditary mechanisms since Gregor Mendel’s famous experiments, gene concepts have always remained vague, notwithstanding their central role in biology. During over hundred years of genetic research, gene concepts have often and dynamically changed to accommodate novel experimental findings, without ever providing a generally accepted definition of the ‘gene.’ Yet, the distinction between ‘regulatory genes’ and ‘structural genes’ has remained a common theme in modern gene concepts since the definition of the operon-model. This distinction is now challenged by recent findings which suggest that, at least in eukaryotes, structural genes may in many situations have a regulatory function that is independent of the function of the gene product (protein or non-coding RNA molecule). This brief paper discusses these new findings and some possible implications for the notion of the ‘regulatory gene.’
Keywords Gene concepts  Regulatory genes  MicroRNAs  Pseudogenes  Transcript function
Categories (categorize this paper)
Options
 Save to my reading list
Follow the author(s)
My bibliography
Export citation
Find it on Scholar
Edit this record
Mark as duplicate
Revision history Request removal from index
 
Download options
PhilPapers Archive


Upload a copy of this paper     Check publisher's policy on self-archival     Papers currently archived: 10,269
External links
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library
References found in this work BETA
Paul E. Griffiths & Karola Stotz (2007). Gene. In David L. Hull & Michael Ruse (eds.), The Cambridge Companion to the Philosophy of Biology. Cambridge University Press.
Hans-Jörg Rheinberger, Gene. Stanford Encyclopedia of Philosophy.
Citations of this work BETA

No citations found.

Similar books and articles
Petter Portin (2002). Historical Development of the Concept of the Gene. Journal of Medicine and Philosophy 27 (3):257 – 286.
Thomas A. C. Reydon (2009). Gene Names as Proper Names of Individuals: An Assessment. British Journal for the Philosophy of Science 60 (2):409-432.
Karola Stotz & Paul Griffiths (2004). Genes: Philosophical Analyses Put to the Test. History and Philosophy of the Life Sciences 26 (1):5 - 28.
Holmes Rolston (2006). What is a Gene? From Molecules to Metaphysics. Theoretical Medicine and Bioethics 27 (6):471-497.
C. Kenneth Waters (1994). Genes Made Molecular. Philosophy of Science 61 (2):163-185.
Analytics

Monthly downloads

Added to index

2011-04-01

Total downloads

37 ( #43,416 of 1,096,179 )

Recent downloads (6 months)

4 ( #54,990 of 1,096,179 )

How can I increase my downloads?

My notes
Sign in to use this feature


Discussion
Start a new thread
Order:
There  are no threads in this forum
Nothing in this forum yet.