Transmission of mechanical stresses within the cytoskeleton of adherent cells: A theoretical analysis based on a multi-component cell model
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jack Alan Reynolds
Learn more about PhilPapers
Acta Biotheoretica 52 (4):323-341 (2004)
How environmental mechanical forces affect cellular functions is a central problem in cell biology. Theoretical models of cellular biomechanics provide relevant tools for understanding how the contributions of deformable intracellular components and specific adhesion conditions at the cell interface are integrated for determining the overall balance of mechanical forces within the cell. We investigate here the spatial distributions of intracellular stresses when adherent cells are probed by magnetic twisting cytometry. The influence of the cell nucleus stiffness on the simulated nonlinear torque-bead rotation response is analyzed by considering a finite element multi-component cell model in which the cell and its nucleus are considered as different hyperelastic materials. We additionally take into account the mechanical properties of the basal cell cortex, which can be affected by the interaction of the basal cell membrane with the extracellular substrate. In agreement with data obtained on epithelial cells, the simulated behaviour of the cell model relates the hyperelastic response observed at the entire cell scale to the distribution of stresses and strains within the nucleus and the cytoskeleton, up to cell adhesion areas. These results, which indicate how mechanical forces are transmitted at distant points through the cytoskeleton, are compared to recent data imaging the highly localized distribution of intracellular stresses.
|Keywords||Philosophy Philosophy of Biology Evolutionary Biology|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
MiloŠ Jílek (1975). Stochastic Development of Cell Populations Under Non-Homogeneous Conditions. Acta Biotheoretica 24 (3-4):108-119.
Jürgen Bereiter-Hahn (1985). Architecture of Tissue Cells the Structural Basis Which Determines Shape and Locomotion of Cells. Acta Biotheoretica 34 (2-4):139-148.
I. Ferrenq, L. Tranqui, B. Vailhé, P. Y. Gumery & P. Tracqui (1997). Modelling Biological Gel Contraction by Cells: Mechanocellular Formulation and Cell Traction Force Quantification. Acta Biotheoretica 45 (3-4):267-293.
Caroline Rosello, Pascal Ballet, Emmanuelle Planus & Philippe Tracqui (2004). Model Driven Quantification of Individual and Collective Cell Migration. Acta Biotheoretica 52 (4):343-363.
D. Manoussaki, S. R. Lubkin, R. B. Vemon & J. D. Murray (1996). A Mechanical Model for the Formation of Vascular Networks in Vitro. Acta Biotheoretica 44 (3-4):271-282.
Didier Morel, Raphaël Marcelpoil & Gérard Brugal (2001). A Proliferation Control Network Model: The Simulation of Two-Dimensional Epithelial Homeostasis. Acta Biotheoretica 49 (4):219-234.
Valérie M. Laurent, Patrick Cañadas, Redouane Fodil, Emmanuelle Planus, Atef Asnacios, Sylvie Wendling & Daniel Isabey (2002). Tensegrity Behaviour of Cortical and Cytosolic Cytoskeletal Components in Twisted Living Adherent Cells. Acta Biotheoretica 50 (4):331-356.
Melinda B. Fagan (2011). Social Experiments in Stem Cell Biology. Perspectives on Science 19 (3):235-262.
Christine Reder (2001). Mutated mtDNA Distribution in Exponentially Growing Cell Cultures and How the Segregation Rate is Increased by the Mitochondrial Compartments. Acta Biotheoretica 49 (4):235-245.
Added to index2009-01-28
Total downloads8 ( #368,535 of 1,789,994 )
Recent downloads (6 months)1 ( #424,764 of 1,789,994 )
How can I increase my downloads?