Whether meaning is compositional has been a major issue in linguistics and formal philosophy of language for the last 2 decades. Semantic holism is widely and plausibly considered as an objection to the principle of semantic compositionality therein. It comes as a surprise that the holistic peculiarities of scientific language have been rarely addressed in formal accounts so far, given that semantic holism has its roots in the philosophy of science. For this reason, a model-theoretic approach to semantic holism in (...) the language of science is presented here. This approach preserves compositionality to a large extent. *Received September 2009; revised February 2010. †To contact the author, please write to: Seminar for Philosophy, Logic, and Theory of Science, Hauspostfach 49, Ludwig-Maximilians-Universität, Munich 80539, Germany; e-mail: [email protected]. (shrink)