Selective retrieval of task-relevant information often facilitates memory retention of that information. However, it is still unclear if selective retrieval of task-relevant information can alter memory for task-irrelevant information, and the role of emotional arousal in it. In two experiments, we used emotional and neutral faces as stimuli, and participants were asked to memorise the name (who is this person?) and location (where does he/she come from?) associated with each face in initial study. Then, half of the studied faces were (...) presented as cues, and participants were asked to retrieve the corresponding names (Experiment 1) or locations (Experiment 2). Finally, all the faces were presented and participants were asked to retrieve both the corresponding names and locations. The results of the final test showed that retrieval practice not only enhanced memory of task-relevant information but also enhanced memory of task-irrelevant information. More importantly, negative emotion amplified the retrieval practice effect overall, with a larger retrieval-induced benefit for the negative than neutral condition. These findings demonstrated an emotional arousal amplification effect on retrieval-induced enhancement effects, suggesting that the advantage of the retrieved memory representations can be amplified by emotional arousal even without explicit goals in a task setting. (shrink)

Neddylation, a ubiquitylation‐like post‐translational modification, is catalyzed by a cascade composed of three enzymes: E1 activating enzyme, E2 conjugating enzyme, and E3 ligase with cullins as physiological substrates. Specifically, neddylation E2 UBE2M couples with E3 RBX1 to neddylate cullins 1–4, whereas neddylation E2 UBE2F couples with E3 RBX2/SAG to neddylate cullin 5, leading to activation of CRL1‐4 (Cullin‐RING ligases 1–4) and CRL5, respectively. While over‐activation of the neddylation‐CRLs axis occurs frequently in many human cancers, how neddylation‐CRLs regulate the function of (...) immune cells, particularly Treg cells was previously unknown. To this end, we recently performed Treg selective knockout of two neddylation E2s and two E3s, individually, driven by Foxp3‐Cre, and found that while the Ube2f‐Sag E2/E3 pair plays a minimal role, if any, the Ube2m‐Rbx1 pair is essential for the maintenance of Treg functionality, since their deletion triggers robust inflammatory response with autoimmune phenotypes. Milder phenotype severity upon Treg KO of upstream Ube2m than that of downstream Rbx1 strongly suggested that Rbx1 regulates Treg function in a manner dependent and independent of neddylation. (shrink)

At this time, as we approach the imminent end of a century, it is amusing to look back at the changes that have taken place in the manners in which people have addressed one another in society over the last hundred years. If we are to locate, among all the terms that relate to social address, those that are, as Raymond Williams calls them, the "keywords,"1 then, to be sure, the term tongzhi or comrade is bound to be at the (...) head of the list. (shrink)

An old peasant of Shanxi Province once said: "Our village used to have a landlord and two rich peasants; at that time, a small number of people had already, in a sense, became rich first—ahead of others. If we had known then what we know now, we wouldn't have bothered to go through all this rigmarole to get to where we are.".

At this time, as we approach the imminent end of a century, it is amusing to look back at the changes that have taken place in the manners in which people have addressed one another in society over the last hundred years. If we are to locate, among all the terms that relate to social address, those that are, as Raymond Williams calls them, the "keywords,"1 then, to be sure, the term tongzhi or comrade is bound to be at the (...) head of the list. (shrink)

An old peasant of Shanxi Province once said: "Our village used to have a landlord and two rich peasants; at that time, a small number of people had already, in a sense, became rich first—ahead of others. If we had known then what we know now, we wouldn't have bothered to go through all this rigmarole to get to where we are.".

The Concept of Life and Death of Chuang-tzu have inherited and developed Confucianism and Taoism thoughts, establishing Ontological foundation of "Life - Body", distinguishing the transcendental concept of "Dead Heart" and the empirical concept of "Death Body", as well as proposing the thought of "Equivalence of Life and Death" finally. The logic Reasoning of Chuang-tzu "Equivalence of Life and Death", start from constructing the equal status of "Life" and “Death" from ontological argument. Life and Death then are reduced to be (...) a natural phenomenon to dispel its mystery. With emphasizing the social connotation of life and death, the difference between them has been removed, and finally the Thought experiment of "Chuang-tzu dreaming butterfly" has deepened the idea of "Equivalence of Life and Death". The Ideological Characteristic of the Concept of Life and Death of Chuang-tzu mainly reflects in the aspects of Ontology, Epistemology and Ethical practice. (shrink)

Aiming at the allocation of scarce medical resources, Immanuel and other scholars have put forward a set of influential ethical values and guiding principles. It assigns the priority of resource allocation to those whose lives can be saved and maximized, those who can bring the greatest instrumental value, and those who are the worse off. For other members of society, random selection under the same conditions is adopted. Following the Rawlsian "lexical order, lexicographical" rule, this priority arrangement requires that the (...) "utilitarian principle" should be placed before the "equality principle", and the "instrumental difference principle", the "integrity difference principle" and the "fair opportunity principle" in turn acts on specific distribution agents. Although the framework and its priority rules have obvious drawbacks when faced with Medical Resources Squeeze and other dilemmas, with the help of an understanding of its internal structure, it can effectively respond to the four core issues in the allocation of scarce medical resources. (shrink)

Different understanding on Aristotelian distributive justice results in two main factions: holism and egalitarianism. Dennis McKerlie, one of the representatives of holism, criticized Martha Nussbaum's interpretation as an egalitarian. McKerlie argued that Nussbaum did not attach enough importance to the Proportional equality and Aristotelian Common good, as well as a deviation in the understanding of the concept of distribution. The defense of egalitarianism is that Aristotle's emphasis on the rational equality of citizens and the ontological presupposition of primal equality show (...) Aristotelian egalitarian tendencies. (shrink)

In the evolution of Chinese and Western literatures, the emphasis on the "strength" of "courage" is gradually given to the "mind" of "courage", that is the intention of the Agent. The connotation of Chinese and Western traditional thoughts of "courage" reflected in the distinction between the "physical courage" and "moral courage". Philosophers distinguish moral courage from physical courage, which does not seem to be clear and complete. Moral courage however as moral elements have been distinguished from "courage as a virtue". (...) The behavior of "moral courage" must be "supernormal behavior", which is the embodiment of moral choice and moral practice in a specific situation. The Agent of "moral courage" has particularity, the behavior itself is in a certain situation, and the behavioral consequences show severe. (shrink)

Hans Jonas 's responsibility ethics is an important achievement of modern technology criticism and ethical theory innovation. The maturity of Jonas's ethical thought has gone through three main stages, namely, the critique of modern technology, the reflection of traditional ethics and the construction of the " Future-oriented " Responsibility Ethics. Jonas's criticism of modern technology not only has a strong epochal character but also carries on the spirit of social criticism since Marx. His insight into the traditional ethics theory and (...) the ethical characteristics of the technical age constituted the background of the Responsibility ethics. Jonas's responsibility ethics is not only the return of "responsibility" spirit in ethics but also the dimension of "Future", which is the characteristic of his theory. Through criticism, reflection and construction, Jonas formed this kind of asymmetrical ethics thought of "Future-oriented" Responsibility and faced the challenge of modern technology. (shrink)

With the development of sharing economy, a consensus to study this area from the perspective of morality and ethics has been recently reached. The key point of this study is the ethical basis of sharing economy. It should be noticed that the conceptual framework of sharing economy must be grounded within the market economy, technological innovation, and the spirit of "rational cooperation". It is, therefore, necessary to realize that the sharing economy is based on the Contractual Ethics internally rooted in (...) the market economy, the Technical Ethics which is coordinated with technological innovation, and the Universal Ethics produced by the cooperative reason. The three concept of ethics lay the ethical foundation of sharing economy together. (shrink)

Through the analysis of facial feature extraction technology, this paper designs a lightweight convolutional neural network. The LW-CNN model adopts a separable convolution structure, which can propose more accurate features with fewer parameters and can extract 3D feature points of a human face. In order to enhance the accuracy of feature extraction, a face detection method based on the inverted triangle structure is used to detect the face frame of the images in the training set before the model extracts the (...) features. Aiming at the problem that the feature extraction algorithm based on the difference criterion cannot effectively extract the discriminative information, the Generalized Multiple Maximum Dispersion Difference Criterion and the corresponding feature extraction algorithm are proposed. The algorithm uses the difference criterion instead of the entropy criterion to avoid the “small sample” problem, and the use of QR decomposition can extract more effective discriminative features for facial recognition, while also reducing the computational complexity of feature extraction. Compared with traditional feature extraction methods, GMMSD avoids the problem of “small samples” and does not require preprocessing steps on the samples; it uses QR decomposition to extract features from the original samples and retains the distribution characteristics of the original samples. According to different change matrices, GMMSD can evolve into different feature extraction algorithms, which shows the generalized characteristics of GMMSD. Experiments show that GMMSD can effectively extract facial identification features and improve the accuracy of facial recognition. (shrink)

This paper endeavors to appraise scholarly works from the 1940s to the contemporary era, examining the scientific quest to transpose human cognition and consciousness into a digital surrogate, while contemplating the potential ramifications should humanity attain such an abstract level of intellect. The discourse commences with an explication of theories concerning consciousness, progressing to the Turing Test apparatus, and intersecting with Damasio’s research on the human cerebrum, particularly in relation to consciousness, thereby establishing congruence between the Turing Test and Damasio’s (...) notions of consciousness. Subsequently, the narrative traverses the evolutionary chronology of transmuting human cognition into machine sapience, and delves into the fervent endeavors to metamorphose human minds into synthetic counterparts. Additionally, theoretical perspectives from the domains of philosophy, psychology, and neuroscience provide insight into the constraints intrinsic to AI implementations, contentious hypotheses, the perils concealed within artificial networks, and the ethical considerations necessitated by AI frameworks. Furthermore, contemplation of prospective repercussions facilitates the refinement of strategic approaches to safeguard our future Augmented Age Realities within AI, circumventing the prospect of inhabiting an intimidating technopolis where a mere 30% monopolize the intellect and ingenuity of the remaining 70% of human minds. (shrink)

The original innovation talents and their achievements promote the development of natural science and are regarded as a symbol of the national comprehensive power. This study explores the process that causes original innovation talents’ personality, uses fuzzy-set qualitative comparative analysis, and explores the linkage between configurations made up of early growth experiences and personality. We took Nobel Prize winners as samples and discovered that high responsibility was inspired by high family democracy driving, high family size driving, high family function driving, (...) and high teaching democracy driving; high extroversion was inspired by high family size driving, high family democracy driving, and high family status driving; high openness was inspired by high family status driving, high family democracy driving, high family size driving, both high open teaching and educational level driving, as well as high peer support driving; high or non-high family status brought high extroversion or openness; non-high teacher accomplishments and teacher-student relationships produced high openness; non-high extroversion came with non-high teacher-student relationship. We proposed strategies for strengthening the positive effects or avoiding the negative effects of early growing-up experiences on personality. (shrink)

Alzheimer's disease is characterized by plaques of amyloid-beta peptide, cleaved from amyloid-beta protein precursor . Our hypothesis is that lifespan profiles of AD-associated mRNA and protein levels in monkeys would differ from mice and that differential lifespan expression profiles would be useful to understand human AD pathogenesis. We compared profiles of AbetaPP mRNA, AbetaPP protein, and Abeta levels in rodents and primates. We also tracked a transcriptional regulator of the AbetaPP gene, specificity protein 1 , and the beta amyloid precursor (...) cleaving enzyme . In mice, AbetaPP and SP1 mRNA and their protein products were elevated late in life; Abeta levels declined in old age. In monkeys, SP1, AbetaPP, and BACE1 mRNA declined in old age, while protein products and Abeta levels rose. Proteolytic processing in both species did not match production of Abeta. In primates, AbetaPP and SP1 mRNA levels coordinate, but an inverse relationship exists with corresponding protein products as well as Abeta levels. Comparison of human DNA and mRNA sequences to monkey and mouse counterparts revealed structural features that may explain differences in transcriptional and translational processing. These findings are important for selecting appropriate models for AD and other age-related diseases. (shrink)

本书主要包括: 导论、困难群体概念的界定与研究现状、珠江三角洲地区困难群体伦理生态的实证考量等内容.

di 1 juan. Shi lun juan -- di 2 juan. Fan chou juan -- di 3 juan. Men lei juan.