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  1.  58
    Calibration: A Conceptual Framework Applied to Scientific Practices Which Investigate Natural Phenomena by Means of Standardized Instruments.Léna Soler, Frédéric Wieber, Catherine Allamel-Raffin, Jean-Luc Gangloff, Catherine Dufour & Emiliano Trizio - 2013 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 44 (2):263-317.
    This paper deals with calibration in scientific practices which investigate relatively well-understood natural phenomena by means of already standardized instrumental devices. Calibration is a crucial topic, since it conditions the reliability of instrumental procedures in science. Yet although important, calibration is a relatively neglected topic. We think more attention should be devoted to calibration. The paper attempts to take a step in this direction. The aims are two-fold: (1) to characterize calibration in a relatively simple kind of scientific practices; (2) (...)
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  2.  3
    Models, Parameterization, and Software: Epistemic Opacity in Computational Chemistry.Frédéric Wieber & Alexandre Hocquet - 2020 - Perspectives on Science 28 (5):610-629.
    Computational chemistry grew in a new era of “desktop modeling,” which coincided with a growing demand for modeling software, especially from the pharmaceutical industry. Parameterization of models in computational chemistry is an arduous enterprise, and we argue that this activity leads, in this specific context, to tensions among scientists regarding the epistemic opacity transparency of parameterized methods and the software implementing them. We relate one flame war from the Computational Chemistry mailing List in order to assess in detail the relationships (...)
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    Racines scientifiques de la conception dite rationnelle de médicaments sur ordinateur : pour une histoire de la modélisation moléculaire.Frédéric Wieber - 2008 - Philosophia Scientiae 12 (2):93-109.
    Computational methods have been used in the pre-clinical design of therapeutic molecules since the 1970’s as part of a strategy known as “rational drug design”. An analysis of this approach is developed. Two contextualisations of these practices are then offered. First, some results of the historiography of medicine help to clarify the particular doctrine of drug to which this strategy is linked. Secondly, since the declared-rationality of this approach is based on scientific tools developed in chemistry, an analysis of their (...)
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    Racines Scientifiques de la Conception Dite Rationnelle de Médicaments Sur Ordinateur : Pour Une Histoire de la Modélisation Moléculaire.Frédéric Wieber - 2008 - Philosophia Scientae 12:93-109.
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