Results for 'Iraklis Ioannidis'

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  1.  26
    No Empathy for Empathy: An Existential Reading of Husserl’s Forgotten Question.Iraklis Ioannidis - 2019 - International Journal of Philosophical Studies 27 (2):201-223.
    Empathy is a term used to denote our experience of connecting or feeling with an Other. The term has been used both by psychologists and phenomenologists as a supplement for our biological capacity to understand an Other. In this paper I would like to challenge the possibility of such empathy. If empathy is employed to mean that we know another person’s feelings, then I argue that this is impossible. I argue that there is an equivocation in the use of the (...)
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  2.  48
    The Other as the Essence of Existence: A Journal of a Philosophical Passage to Altruism.Iraklis Ioannidis - 2019 - Dissertation, University of Glasgow
    This research is about altruism. In our first chapter, our quest to find whether we are essentially altruistic starts with questioning particular ways of inquiry and proposes a philosophy of unbracketing. In our second chapter, we realise that our proposal starts with an imperative – a prescription. We begin by meditating on the phenomenon of prescription which seems to precede all ways of inquiry. Our analysis of prescription reveals that altruism is to prescribe oneself towards an Other. This type of (...)
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  3.  92
    Mechanisms, Then and Now: From Metaphysics to Practice.Stathis Psillos & Stavros Ioannidis - 2019 - In Brigitte Falkenburg & Gregor Schiemann (eds.), Mechanistic Explanations in Physics and Beyond. Cham: Springer Nature. pp. 11-31.
    For many old and new mechanists, Mechanism is both a metaphysical position and a thesis about scientific methodology. In this paper we discuss the relation between the metaphysics of mechanisms and the role of mechanical explanation in the practice of science, by presenting and comparing the key tenets of Old and New Mechanism. First, by focusing on the case of gravity, we show how the metaphysics of Old Mechanism constrained scientific explanation, and discuss Newton’s critique of Old Mechanism. Second, we (...)
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  4.  31
    Mechanistic Causation: Difference-Making is Enough.Stathis Psillos & Stavros Ioannidis - 2019 - Teorema: International Journal of Philosophy 3 (38):53-75.
    In this paper we defend the view that mechanisms are underpinned by networks of difference-making relations. First, we distinguish and criticise two different kinds of arguments in favour of an activity-based understanding of mechanism: Glennan’s metaphysics- first approach and Illari and Williamson’s science-first approach. Second, we present an alternative difference-making view of mechanism and illustrate it by looking at the history of the case of scurvy prevention. We use the case of scurvy to argue that evidence for a mechanism just (...)
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  5. In Defense of Methodological Mechanism: The Case of Apoptosis.Stavros Ioannidis & Stathis Psillos - 2017 - Axiomathes 27 (6):601-619.
    This paper advances the thesis of methodological mechanism, the claim that to be committed to mechanism is to adopt a certain methodological postulate, i.e. to look for causal pathways for the phenomena of interest. We argue that methodological mechanism incorporates a minimal account of understanding mechanisms, according to which a mechanism just is a causal pathway described in the language of theory. In order to argue for this position we discuss a central example of a biological mechanism, the mechanism of (...)
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  6.  31
    Publication and Other Reporting Biases in Cognitive Sciences: Detection, Prevalence, and Prevention.John P. A. Ioannidis, Marcus R. Munafò, Paolo Fusar-Poli, Brian A. Nosek & Sean P. David - 2014 - Trends in Cognitive Sciences 18 (5):235-241.
  7.  1
    When Null Hypothesis Significance Testing Is Unsuitable for Research: A Reassessment.Denes Szucs & John P. A. Ioannidis - 2017 - Frontiers in Human Neuroscience 11.
  8. Informed Consent, Big Data, and the Oxymoron of Research That Is Not Research.John P. A. Ioannidis - 2013 - American Journal of Bioethics 13 (4):40 - 42.
    (2013). Informed Consent, Big Data, and the Oxymoron of Research That Is Not Research. The American Journal of Bioethics: Vol. 13, No. 4, pp. 40-42. doi: 10.1080/15265161.2013.768864.
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  9.  58
    Rani Lill Anjum & Stephen Mumford What Tends to Be: The Philosophy of Dispositional Modality. London & New York: Routledge, Hbk Pp. X+193. [REVIEW]Stathis Psillos & Stavros Ioannidis - 2019 - Notre Dame Philosophical Reviews 201903.
    There seems to be widespread agreement that there are two modal values: necessity and possibility. X is necessary if it is not possible that not-X; and Y is possible if it is not necessary that not-Y. In their path-breaking book, Rani Lill Anjum and Stephen Mumford defend the radical idea that there is a third modal value, weaker than necessity and stronger than possibility. This third value is dubbed 'dispositional modality' (DM) or 'tendency' and is taken to be an irreducible (...)
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  10. Mechanisms, Counterfactuals and Laws.Stavros Ioannidis & Stathis Psillos - 2018 - In Stuart Glennan & Phyllis Illari (eds.), The Routledge Handbook of Mechanisms and Mechanical Philosophy. Routledge. pp. 144-156.
    In this chapter we examine the relation between mechanisms and laws/counterfactuals by revisiting the main notions of mechanism found in the literature. We distinguish between two different conceptions of ‘mechanism’: mechanisms-of underlie or constitute a causal process; mechanisms-for are complex systems that function so as to produce a certain behavior. According to some mechanists, a mechanism fulfills both of these roles simultaneously. The main argument of the chapter is that there is an asymmetrical dependence between both kinds of mechanisms and (...)
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  11.  84
    Functions and Functional Explanation Revisited: Philippe Huneman : Functions: Selection and Mechanisms. Dordrecht: Springer, 2013, Viii+243pp, €106,95 HB.Stavros Ioannidis - 2014 - Metascience 24 (2):253-258.
    Functions: selection and mechanisms is a collection of eleven original contributions to the philosophical debates surrounding functions. In the words of Philippe Huneman, editor of the volume, the aim of the book is to reflect “upon the metaphysics of function and the various problems that functional explanations raise” . This is accomplished by a diverse collection of chapters that focus on various aspects of the main topic. A collection such as this is certainly welcome. As Huneman notes in his introduction, (...)
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  12.  69
    Effectiveness of Antidepressants: An Evidence Myth Constructed From a Thousand Randomized Trials? [REVIEW]John P. A. Ioannidis - 2008 - Philosophy, Ethics, and Humanities in Medicine 3:14.
    Antidepressants, in particular newer agents, are among the most widely prescribed medications worldwide with annual sales of billions of dollars. The introduction of these agents in the market has passed through seemingly strict regulatory control. Over a thousand randomized trials have been conducted with antidepressants. Statistically significant benefits have been repeatedly demonstrated and the medical literature is flooded with several hundreds of.
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  13.  65
    Ethics and Epistemology in Big Data Research.Wendy Lipworth, Paul H. Mason, Ian Kerridge & John P. A. Ioannidis - 2017 - Journal of Bioethical Inquiry 14 (4):489-500.
    Biomedical innovation and translation are increasingly emphasizing research using “big data.” The hope is that big data methods will both speed up research and make its results more applicable to “real-world” patients and health services. While big data research has been embraced by scientists, politicians, industry, and the public, numerous ethical, organizational, and technical/methodological concerns have also been raised. With respect to technical and methodological concerns, there is a view that these will be resolved through sophisticated information technologies, predictive algorithms, (...)
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  14.  46
    Mechanisms in Practice: A Methodological Approach.Stavros Ioannidis & Stathis Psillos - 2018 - Journal of Evaluation in Clinical Practice 24 (5):1177-1183.
    In this paper we offer a minimal characterisation of the concept of mechanism in biomedicine, according to which a mechanism is a theoretically described causal pathway. We argue that this conceptionan be drawn from scientific practice, as illustrated by how a central biological and biomedical mechanism, the mechanism of apoptosis, was first identified and characterised. We will use the example of cytological and biochemical theoretical descriptions of the mechanism of apoptosis to draw lessons about the meaning of the concept of (...)
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  15. How Development Changes Evolution: Conceptual and Historical Issues in Evolutionary Developmental Biology.Stavros Ioannidis - 2008 - Biology and Philosophy 23 (4):567-578.
    Evolutionary developmental biology (Evo-Devo) is a new and rapidly developing field of biology which focuses on questions in the intersection of evolution and development and has been seen by many as a potential synthesis of these two fields. This synthesis is the topic of the books reviewed here. Integrating Evolution and Development (edited by Roger Sansom and Robert Brandon), is a collection of papers on conceptual issues in Evo-Devo, while From Embryology to Evo-Devo (edited by Manfred Laubichler and Jane Maienschein) (...)
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  16. Regulatory Evolution and Theoretical Arguments in Evolutionary Biology.Stavros Ioannidis - 2013 - Science & Education 22 (2):279-292.
    The cis-regulatory hypothesis is one of the most important claims of evolutionary developmental biology. In this paper I examine the theoretical argument for cis-regulatory evolution and its role within evolutionary theorizing. I show that, although the argument has some weaknesses, it acts as a useful example for the importance of current scientific debates for science education.
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  17.  29
    Criterion and Incremental Validity of the Emotion Regulation Questionnaire.Christos A. Ioannidis & A. B. Siegling - 2015 - Frontiers in Psychology 6.
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  18.  33
    Interpretation of Tests of Heterogeneity and Bias in Meta‐Analysis.John P. A. Ioannidis - 2008 - Journal of Evaluation in Clinical Practice 14 (5):951-957.
  19.  27
    Therapy and Prevention for Mental Health: What If Mental Diseases Are Mostly Not Brain Disorders?John P. A. Ioannidis - 2019 - Behavioral and Brain Sciences 42.
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  20. Some Foundational Debates in Philosophy of Biology: Francisco J. Ayala and Robert Arp : Contemporary Debates in Philosophy of Biology. Oxford: Blackwell, 2009, Xii+426pp, £21.99. [REVIEW]Stavros Ioannidis - 2011 - Metascience 20 (2):351-354.
    What are the main debates in philosophy of biology today? The present book (part of the series Contemporary Debates in Philosophy) attempts to identify and discuss some of the most important of these. The endeavour is, I think, successful; the collection is a valuable contribution to the literature of philosophy of biology. Before discussing some particular lines of thought in the book, some brief remarks on its structure and organization: the book consists of ten parts, each of which is centred (...)
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  21.  87
    The Philosophy of Stem Cells: Melinda Bonnie Fagan: Philosophy of Stem Cell Biology: Knowledge in Flesh and Blood. Basingstoke and New York: Palgrave Macmillan, 2013, Xx+274pp, £66.00 HB. [REVIEW]Stavros Ioannidis - 2015 - Metascience 24 (2):285-288.
    Melinda Fagan’s book on the philosophy of stem cell biology is a superb discussion of this exciting field of contemporary science, and the first book-length philosophical treatment of the subject. It contains a detailed and insightful examination of stem cell science, its structure, methods, and challenges.The book does not require any previous knowledge of stem cell biology—all the relevant scientific details and concepts, the central experimental procedures and results, as well as the historical development of the field, are presented in (...)
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  22. Book Notice of Rosenberg & Arp (Eds) Philosophy of Biology: An Anthology. [REVIEW]Stavros Ioannidis - 2012 - Metascience 21 (1):249-250.
  23.  13
    Why Replication has More Scientific Value Than Original Discovery.John P. A. Ioannidis - 2018 - Behavioral and Brain Sciences 41.
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  24.  30
    Are the Conditions of Statehood Sufficient? An Argument in Favour of Popular Sovereignty as an Additional Condition of Statehood.Christoforos Ioannidis - 2015 - Jurisprudencija: Mokslo darbu žurnalas 21 (4):974.
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  25.  13
    Translational Research May Be Most Successful When It Fails.John P. A. Ioannidis - 2015 - Hastings Center Report 45 (2):39-40.
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  26.  10
    Il diritto ad avere diritti europei. Importanza e problemi dell’azione comune contro i deficit sistemici.Armin von Bogdandy & Michael Ioannidis - 2014 - Scienza and Politica. Per Una Storia Delle Dottrine 26 (50).
    This article examines the current problems and tension that characterize the idea of the right to have rights, considered as a cornerstone of the European Union's project. The systemic deficit matter is discussed as the main problematic to achieve the entirety of the previous concept, and some systemic deficit profile are identified. Moreover through the example of the Greek experience the article shows a possible way of common action to solve the systemic deficit. Finally, the authors talk about how to (...)
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  27.  7
    Sémiotique Picturale: Analyse D’Une Mosaïque Byzantine.Alexandros-Phaidon Lagopoulos & Andréas Ioannidis - 1977 - Semiotica 21 (1-2).
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  28.  72
    Should We Treat Depression with Drugs or Psychological Interventions? A Reply to Ioannidis.John Davis, William Giakas, Jie Que, Pavan Passad & Stefan Leucht - 2011 - Philosophy, Ethics, and Humanities in Medicine 6:8-.
    We reply to the Ioannidis's paper "Effectiveness of antidepressants; an evidence based myth constructed from a thousand controlled trials." We disagree that antidepressants have no greater efficacy than placebo. We present the efficacy from hundreds of trials in terms of the percentage of patients with a substantial clinical response (a 50% improvement or more symptomatic reduction). This meta-analysis finds that 42-70% of depressed patients improve with drug and 21%-39% improve with placebo. The response benefit of antidepressant treatment is 33%-11% (...)
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  29.  5
    The Red-Attractiveness Effect, Applying the Ioannidis and Trikalinos Test, and the Broader Scientific Context: A Reply to Francis.Andrew J. Elliot & Markus A. Maier - 2013 - Journal of Experimental Psychology: General 142 (1):297-300.
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  30. Global and Local Pessimistic Meta-Inductions.Samuel Ruhmkorff - 2013 - International Studies in the Philosophy of Science 27 (4):409-428.
    The global pessimistic meta-induction argues from the falsity of scientific theories accepted in the past to the likely falsity of currently accepted scientific theories. I contend that this argument commits a statistical error previously unmentioned in the literature and is self-undermining. I then compare the global pessimistic meta-induction to a local pessimistic meta-induction based on recent negative assessments of the reliability of medical research. If there is any future in drawing pessimistic conclusions from the history of science, it lies in (...)
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  31. Just a Paradigm: Evidence-Based Medicine in Epistemological Context.Miriam Solomon - 2011 - European Journal for Philosophy of Science 1 (3):451-466.
    Evidence-Based Medicine (EBM) developed from the work of clinical epidemiologists at McMaster University and Oxford University in the 1970s and 1980s and self-consciously presented itself as a "new paradigm" called "evidence-based medicine" in the early 1990s. The techniques of the randomized controlled trial, systematic review and meta-analysis have produced an extensive and powerful body of research. They have also generated a critical literature that raises general concerns about its methods. This paper is a systematic review of the critical literature. It (...)
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  32.  7
    Operational Characteristics of Institutional Review Boards in the United States.Genevieve L. Nesom, Iraklis Petrof & Tyler M. Moore - forthcoming - Ajob Empirical Bioethics:1-11.
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  33.  55
    Why All Published Research Findings Are Likely False (and a Possible Remedy).Richard Sanders - 2017 - Academia.Edu.
    The physiological constraints of our neuro-sensory instrumentation limit the information we receive and from which we fashion our impressions. These limitations precede the psychological issues of data generation and analysis described by Ioannidis [1]. Scientific models widely accepted for at least 50 years [2,3] suggest that the peripheral and central nervous systems do not provide direct information about phenomena as they exist in nature. Instead, perceptible phenomena stimulate sense organs to produce nerve impulses. Sensory nerve impulses are not replicas (...)
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  34.  23
    Ethical Issues in Translational Research.Carlo Petrini - 2010 - Perspectives in Biology and Medicine 53 (4):517-533.
    Translational research is a main focus of current health policy (Albani and Prakken 2009; PLoS Medicine 2008). Translation of biomedical research knowledge to effective clinical treatment is essential to the public good (Lavis et al. 2003). Only 5% of basic science studies showing significant therapeutic promise are successfully translated into clinical application (Contopoulos-Ioannidis, Ntzani, and Ionannidis 2003; FDA 2004). As Hall (2001) observes, this is a problem: "When too many important discoveries lie dormant, the public good suffers" (p. G1127). (...)
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  35.  18
    Detention and Deception: Limits of Ethical Acceptability in Detention Research.Iraklis Harry Minas - 2004 - Monash Bioethics Review 23 (4):69-77.
    The core of Australia’s response to asylum seekers who arrive in an unauthorised manner has been to detain them in immigration detention centres until they are judged to engage Australia’s protection obligations or, if they do not, until they are returned to their country of origin. For a number of asylum seekers this has resulted in very prolonged detention. This policy has aroused a storm of controversy with very polarised positions being taken by participants in the debate. In particular, the (...)
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  36.  39
    Agents, Modeling Processes, and the Allure of Prophecy.William A. Griffin, Manfred D. Laubichler & Werner Callebaut - 2008 - Biological Theory 3 (1):73-78.
    Ioannidis [Why most published research findings are false. PLoS Med 2: e124 ] identifies six factors that contribute to explaining why most of the current published research findings are more likely to be false than true, and argues that for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias. In this article, we argue that three “hot” areas in current biological research, viz., agent-based modeling, evolutionary developmental biology , and systems biology, (...)
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  37.  15
    Formalizing Biology.Werner Callebaut & Manfred D. Laubichler - 2008 - Biological Theory 3 (1):1-2.
    Ioannidis [Why most published research findings are false. PLoS Med 2: e124 ] identifies six factors that contribute to explaining why most of the current published research findings are more likely to be false than true, and argues that for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias. In this article, we argue that three “hot” areas in current biological research, viz., agent-based modeling, evolutionary developmental biology, and systems biology, are (...)
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