ObjectivesThe study aims to investigate the state anxiety of parents of special needs children during the 2019 coronavirus disease epidemic and the influence of parental stress, social support, and other related variables on the anxiety of parents.MethodsBespoke questionnaires of children’s and parent’s mental and behavioral problems during the epidemic were used in the study. We also used the State Anxiety Inventory, the Parenting Stress Index—Short Form-15, the NEO Five-Factor Inventory, and the Multidimensional Scale of Perceived Social Support. The data used (...) in the study were pooled from an online survey of parents of special needs children and analyzed by one-way analysis of variance and multiple linear regression.ResultsOverall, 1,451 individuals were included, of which 402 were fathers and 1,049 were mothers. ANOVA results showed that educational background, family monthly income, and type of their child’s disability made parents’ state anxiety significantly different. The results of multiple linear regression showed that during the epidemic, social support negatively predicted parents’ state anxiety, whereas parenting stress and parental mental and behavioral problems positively predicted parents’ state anxiety.ConclusionsDuring the outbreak of COVID-19, parents of special needs children suffered mental and behavioral problems, together with parenting stress and social support, which influenced their state anxiety. These findings can be used to develop relevant psychological interventions to improve the mental health of vulnerable groups during a pandemic like COVID-19. (shrink)