This work exposes the practices that are controlling education and reducing it to little more than skills development in preparation for work. It questions the strategy of mentoring to show how its dynamic requires docility from the learner and thus perpetuates inequality.

In this unique work, Ken Gale and Jonathan Wyatt bring together three areas of scholarship: collaborative writing as method of inquiry, the philosophical approaches of the French philosopher, Gilles Deleuze, and the performativity of both writing and the "self". The book is a reflexive exploration into the theory and practice of collaborative writing, with their between-the-twos sequences of exchanged writings using a variety of forms and genres at the book's heart. Their collaboration offers an experimental, transgressive and nomadic inquiry into (...) subjectivity. Based upon the authors' joint doctoral dissertation, the book draws for its theoretical base primarily from the work of Deleuze, from both his philosophical "figures" and the insights that he offers into his collaborations with others. It also tells a story, conveying a sense of a relationship developing over time. This book will interest both academics and postgraduate students in the field of qualitative inquiry, including those involved in narrative inquiry, cultural, communication and performance studies, and autoethnography. (shrink)

Although the genetic code is defined by a linear array of nucleotides, it is the three‐dimensional structure of the double helix that regulates most of its cellular functions. Over the past two decades, it has become increasingly clear that aspects of this three‐dimensionality which reflect topological relationships within the double helix (i.e., superhelical twisting, knotting, or tangling) influence virtually every facet of nucleic acid physiology. In vivo, DNA topology is modulated by ubiquitous enzymes known as topoisomerases. The type II enzyme (...) essential to the eukaryotic cell and is required for unlinking daughter chromosomes and maintaining chromosome structure. Moreover, topoisomerase II also has been identified as the primary cellular target for several widely used antineoplastic drugs. Before the physiological functions of topoisomerase II can be effectively dissected or its drug interactions fully exploited, it is imperative to understand the mechanism by which this important enzyme arries out its catalytic cycle. (shrink)