Massive Open Online Course is a new online education model that provides new opportunities and challenges for the development and reform of teaching in colleges and universities. This paper first builds a MOOC-based model of influencing factors of blended learning adaptability. Through investigation and research, it is found that the six influencing factors all have different ways and different degrees of influence on learning adaptability. Among them, learning motivation has a direct and significant impact on learning adaptability, and learning self-efficacy (...) not only has a direct and significant impact on learning adaptability but also has an indirect impact on learning adaptability through learning motivation. Teacher teaching has indirect effects on learning adaptability through learning self-efficacy, learning motivation, and learning support. Learning support not only has a direct and significant impact on learning adaptability but also has an indirect impact on learning adaptability through learning motivation. MOOC platform has a direct and significant impact on learning adaptability. The quality of course content has a direct and significant impact on learning adaptability through the MOOC platform and learning motivation. The creative results of this research are mainly embodied in the combination of theory and practice, exploring and forming related results based on MOOC-based college students’ learning adaptability. According to the MOOC-based learning-adaptive intervention model, teaching practice is carried out to verify the effect of the intervention model from two aspects of student procedural performance and result performance. Finally, in view of the problems existing in traditional computer teaching in colleges and universities, combined with the design ideas and basic characteristics of MOOC, the teaching mode reform of computer courses is analyzed and discussed, and a MOOC-based computer engineering education teaching mode is proposed. (shrink)