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  1.  36
    Polyps, peptides and patterning.Thomas C. G. Bosch & Toshitaka Fujisawa - 2001 - Bioessays 23 (5):420-427.
    Peptides serve as important signalling molecules in development and differentiation in the simple metazoan Hydra. A systematic approach (The Hydra Peptide Project) has revealed that Hydra contains several hundreds of peptide signalling molecules, some of which are neuropeptides and others emanate from epithelial cells. These peptides control biological processes as diverse as muscle contraction, neuron differentiation, and the positional value gradient. Signal peptides cause changes in cell behaviour by controlling target genes such as matrix metalloproteases. The abundance of peptides in (...)
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  2.  13
    Hydra is joining the bandwagon.Toshitaka Fujisawa - 2006 - Bioessays 28 (5):560-562.
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    Important roles for epithelial cell peptides in hydra development.Toshio Takahashi & Toshitaka Fujisawa - 2009 - Bioessays 31 (6):610-619.
    It has been convincingly shown that peptides play important roles in the regulation and maintenance of a variety of tissues and organs in living animals. However, little is known concerning the potential role of peptides as signaling molecules in developmental processes. In Hydra, there is circumstantial evidence that small diffusible molecules act as morphogens in the regulation of patterning processes. In order to view the entire spectrum of peptide signaling molecules, we initiated a project aiming at the systematic identification of (...)
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