BackgroundRich in different kind of potent cells, embryos are used in modern regenerative medicine and research. Neurobiologists today are pushing the boundaries for what can be done with embryos existing in the transitory margins of medicine. Therefore, there is a growing need to develop conceptual frameworks for interpreting the transformative cultural, biological and technical processes involving these aborted, donated and marginal embryos. This article is a contribution to this development of frameworks.MethodsThis article examines different emotional, cognitive and discursive strategies used (...) by neurobiologists in a foetal cell transplantation trial in Parkinson’s disease research, using cells harvested from aborted embryos. Two interviews were analysed in the light of former observations in the processing laboratories, using the anthropologist Mary Douglas’s concept of pollution behaviour and the linguist, philosopher, psychoanalyst and feminist Julia Kristeva’s concept of the abjective to explain and make sense of the findings.ResultsThe findings indicate that the labour performed by the researchers in the trial work involves transforming the foetal material practically, as well as culturally, from trash to treasure. The transformation process contains different phases, and in the interview material we observed that the foetal material or cells were considered objects, subjects or rejected as abject by the researchers handling them, depending on what phase of process or practice they referred to or had experience of. As demonstrated in the analysis, it is the human origin of the cell that makes it abjective and activates pollution discourse, when the researchers talk of their practice.ConclusionsThe marginal and ambiguous status of the embryo that emerges in the accounts turns the scientists handling foetal cells into liminal characters in modern medicine. Focusing on how practical as well as emotional and cultural strategies and rationalizations of the researchers emerge in interview accounts, this study adds insights on the rationale of practically procuring, transforming and utilizing the foetal material to the already existing studies focused on the donations. We also discuss why the use and refinement of a tissue, around which there is practical consensus but cultural ambiguity, deserves further investigation. (shrink)

Artikelns utgångspunkt är att dagens biomedicinska samhälle ger upphov till frågor om teknikens möjligheter och risker. Avstamp tas i Ulrich Becks diskussion om att dessa motpoler föder en reflexiv modernitet. Ambitionen är att undersöka hur detta reflexiva tillstånd försiggår på ett individuellt plan, närmare bestämt inom en yrkesgrupp som bedriver omdebatterad biomedicinsk forskning. Den empiriska ingången är diskussioner om etik som författaren har haft med forskare från Lund Stem Cell Center. Forskarnas funderingar präglas av komplexitet och motsägelsefullhet. Å ena sidan (...) förekommer ifrågasättande av den egna forskningen, å andra sidan en pragmatisk inställning som innebär att den laboratoriestyrda verksamheten blir riktgivande. Artikeln visar hur reflexioner om etik får ringa betydelse för hur biomedicinsk kunskap produceras – snarare blir de redskap för forskarna att göra yrkesverksamheten kulturellt hanterlig. Artikeln betonar samtidigt att på sikt får reflexiva etiska samtal betydelse för forskningens praxis. (shrink)