Gene therapy approaches have great promise in the treatment of neurodegenerative disorders and malignant brain tumors. Neuwelt et al. review available viral-mediated gene therapy methods and their blood-brain-barrier (BBB) disruption delivery technique, briefly mentioning nonviral mediated gene therapy methods. This commentary discussed the BBB disruption delivery technique, viral and nonviral mediated gene therapy approaches to Parkinson's disease, and the potential use of antisense oligo to suppress malignant brain tumors.

This report by the WHO Consultative Group on Equity and Universal Health Coverage addresses how countries can make fair progress towards the goal of universal coverage. It explains the relevant tradeoffs between different desirable ends and offers guidance on how to make these tradeoffs.

La cobertura universal de salud está en el centro de la acción actual para fortalecer los sistemas de salud y mejorar el nivel y la distribución de la salud y los servicios de salud. Este documento es el informe fi nal del Grupo Consultivo de la OMS sobre la Equidad y Cobertura Universal de Salud. Aquí se abordan los temas clave de la justicia (fairness) y la equidad que surgen en el camino hacia la cobertura universal de salud. Por lo (...) tanto, el informe es pertinente para cada agente que infl uye en ese camino y en particular para los gobiernos, ya que se encargan de supervisar y guiar el progreso hacia la cobertura universal de salud. (shrink)

This report from the WHO Consultative Group on Equity and Universal Health Coverage offers advice on how to make progress fairly towards universal health coverage.

Delusions are standardly defined as attitudes that are not amenable to change in light of conflicting evidence. But what evidence do people with delusion have for and against it? Do delusions really go against their total evidence? How are the answers affected by different conceptions of evidence? -/- This chapter focuses on how delusions relate to evidence. I consider what delusions-relevant evidence people with delusions have. I give some reasons to think that people typically have evidence for their delusions, and (...) that the evidence they have against them is often overstated. I draw on this discussion to consider whether delusions are evidentially supported and epistemically rational. Finally, I discuss implications for the nature of delusion, responsibility, and treatment and suggest directions for future research. Throughout, the discussion is sensitive to different conceptions of evidence and rationality in epistemology. -/- A central upshot is that what we should say about the epistemic standing of delusions depends substantively on our positions in epistemology, in particular, on the debate between internalists and externalists about evidence. If we want clarity on the epistemic standing of delusions, we need to incorporate more sophisticated tools from epistemology. (shrink)

In this paper, we argue that there are epistemic norms on evidence-gathering and consider consequences for how to understand epistemic normativity. Though the view that there are such norms seems intuitive, it has found surprisingly little defense. Rather, many philosophers have argued that norms on evidence-gathering can only be practical or moral. On a prominent evidentialist version of this position, epistemic norms only apply to responding to the evidence one already has. Here we challenge the orthodoxy. First, we argue that (...) there is no significant normative difference between responding to evidence you have and gathering more evidence. Second, we argue that our practices of epistemically criticizing agents for their poor evidence-gathering indicate the existence of epistemic norms on evidence-gathering. Finally, we show that our thesis has important implications for recent debates about the relationship between epistemic norms and inquiry. (shrink)

This research was carried out in a classroom of the center of comprehensive family development in the municipality of Durango, Mexico. The center trains young people in making crafts. From these young people, 13 teenage mothers ages 15-23, all victims of abuse as children, were selected. With this group, we implemented the philosophical-pedagogical proposal called "Philosophy for children and teenagers," first developed by the American philosopher Matthew Lipman. The main goal was to form a "community of inquiry," where through philosophical (...) dialogue the participants developed cognitive skills, allowing them to share, in an ethical and moral dialogue, their life experiences within a democratic setting. The results were demonstrated through the disclosures made by the participants during the philosophical dialogues, We also recorded the cognitive abilities detected over 20 sessions. We contrast the results with the theories to demonstrate the participants’ cognitive changes. We also observed unexpected findings in other academic fields that facilitate ethical and moral thinking. (shrink)

La materia de este estudio, es la misma que preocupo a la humanidad desde sus albores, siendo abordada por grandes pensadores que van desde Aristoteles hasta Teilhard de Chardin. El presente ensayo propone una solucion cientifica a la coexistencia del libre albedrio humano inmerso en un mundo donde las leyes que rigen la causa-efecto no dejan margen al fenomeno de libertad. Como consecuencia primordial explica el mecanismo natural que sustenta la existencia de un alma inmortal y la existencia de un (...) creador. (shrink)

Structured time (hyle) and its relationship to other elements of physics: matter, energy, space, etc.

The current predominant conception of human rights implies that human beings have objective intrinsic value. In this paper, we defend that there is no satisfactory justification of this claim. In spite of the great variety of theories aimed at explaining objective intrinsic value, all of them share one common problematic feature: they pass from a non-evaluative proposition to an evaluative proposition by asserting that a certain entity has intrinsic value in virtue of having certain non-evaluative features. This is a step (...) that cannot be justified. In light of this negative result, we offer a radically different approach to intrinsic value. Our proposal reinterprets the claim that human beings have intrinsic value in terms of a commitment to value human beings intrinsically. This commitment provides both objective practical reasons for, and a rational explanation of, efforts aimed at defending and promoting human rights, without need to appeal to the existence of objective intrinsic value. (shrink)

Comment définir l’enfant victime? Répondre à cette question est moins simple qu’il n’y paraît et nécessite de relever trois défis : appréhender la connaissance statistique de ce phénomène, comprendre sa dimension politique et, enfin, saisir le contenu juridique des normes nationales et internationales produites dans ce domaine. Cette contribution met en évidence la diversité des approches possibles pour appréhender le sujet, mais aussi les vides juridiques pouvant exister en la matière. La présente contribution propose de faire le point sur l’état (...) du droit et les perspectives d’évolution qui pourraient être envisagées. (shrink)

An alarming number of philosophers and cognitive scientists have argued that mind extends beyond the brain and body. This book evaluates these arguments and suggests that, typically, it does not. A timely and relevant study that exposes the need to develop a more sophisticated theory of cognition, while pointing to a bold new direction in exploring the nature of cognition Articulates and defends the “mark of the cognitive”, a common sense theory used to distinguish between cognitive and non-cognitive processes Challenges (...) the current popularity of extended cognition theory through critical analysis and by pointing out fallacies and shortcoming in the literature Stimulates discussions that will advance debate about the nature of cognition in the cognitive sciences. (shrink)

Understanding Computers and Cognition presents an important and controversial new approach to understanding what computers do and how their functioning is related to human language, thought, and action. While it is a book about computers, Understanding Computers and Cognition goes beyond the specific issues of what computers can or can't do. It is a broad-ranging discussion exploring the background of understanding in which the discourse about computers and technology takes place. Understanding Computers and Cognition is written for a wide audience, (...) not just those professionals involved in computer design or artificial intelligence. It represents an important contribution to the ongoing discussion about what it means to be a machine, and what it means to be human. Book jacket. (shrink)

Introduction: the advance of governmentality -- Foucault, power, and governmentality: introduction; what is governmentality?; beyond the microphysics of power?; from theory of the state to genealogy of the state; history of the art of government; pastoral power; raison d'état; liberal governmentality; five propositions on foucault and governmentality -- Governmentality 3.4.7.: introduction; governmentality after Foucault; governmentality and the political sciences; some problems in governmentality -- Foucault effect redux? some notes on international governmentality studies: constellation; a few preliminary observations; problems and debates (...) in international governmentality studies -- Reconnecting governmentality and genealogy: introduction; genealogy and governmentality; pluralizing genealogy; practicing genealogy; lines of descent: the family tree of power?; counter-memory and re-serialization; the retrieval of forgotten struggles and subjugated knowledges -- Conclusion: encountering governmentality: governmentality as a new cartography of power; from mapping to encountering; governmentality and politics. (shrink)

Resumen Es muy conocida la opinión de Kant en relación con la inmoralidad del suicidio. De ahí que, muchos autores lo consideren como un prohibicionista absoluto. Sin embargo, no hay hasta el momento un análisis puntual sobre la definición metafísica-conceptual del suicidio en la teoría kantiana. En este artículo propongo entender el suicidio en Kant como una muerte física, total, autorreferencial, voluntaria e inmoral. Esta definición contrastará con la privación de la vida, la cual no implica inmoralidad. Al ser voluntarios, (...) tanto la privación de la vida, como el suicidio son actos racionales y entendibles a partir de las máximas de acción. La inmoralidad del suicidio sólo surgirá al considerar la primacía de las razones morales por encima de razones no morales.It is common knowledge theposition of Kant regarding the immorality of suicide. Several authors attribute him an absolutist-forbidden criterion. Nerveless, there is no extended analysis about the metaphysical-conceptual definition of suicide in Kantian theory. In this paper I hold that suicide in Kant can be defined asphysical death, full, self-referential, voluntary, and immoral. This definition conflicts with the definition of deprivation of life which is not immoral. As voluntarily acts, both suicide and deprivation of life are rational acts that can be understood as maxims of action. The immorality property of suicide is due to the primacy of moral over non-moral reasons. (shrink)

We report on the simultaneous determination of complementary wave and particle aspects of light in a double-slit type “welcher-weg” experiment beyond the limitations set by Bohr’s Principle of Complementarity. Applying classical logic, we verify the presence of sharp interference in the single photon regime, while reliably maintaining the information about the particular pinhole through which each individual photon had passed. This experiment poses interesting questions on the validity of Complementarity in cases where measurements techniques that avoid Heisenberg’s uncertainty principle and (...) quantum entanglement are employed. We further argue that the application of classical concepts of waves and particles as embodied in Complementarity leads to a logical inconsistency in the interpretation of this experiment. (shrink)

This article is an edited transcript of the roundtable entitled “What is Philo-Performance?” that took place in Paris on 28 June 2014, within the framework of the “Theatre, Performance, Philosophy International Conference: Crossings and Transfers in Anglo-American Thought”. The conference was organized by Julien Alliot, Flore Garcin-Marrou, Liza Kharoubi and Anna Street from the LAPS, a French research group on performance philosophy.

Resumen El propósito de este trabajo es profundizar en el concepto de actividad de imagen y defender su utilidad como categoría de estudio para comprender diferentes tipos de comportamiento que afectan a la imagen social de los hablantes en la interacción comunicativa: cortesía, descortesía y actividad de autoimagen. Teniendo como base estudios sociopragmáticos del español desde una perspectiva cultural y estudios teóricos en inglés de la última década, se tratará el concepto de actividad de imagen, el cual se caracteriza de (...) acuerdo con dos conceptos claves: el del efecto social que un comportamiento comunicativo tiene sobre las imágenes de los hablantes y el del continuo social, la conexión que se establece entre sus imágenes en la interacción. De esta forma, se propone tratar la actividad de imagen desde dos perspectivas relacionadas: la de la dirección seguida por el efecto social hacia los interactuantes y la de las características de este efecto, siendo su interrelación el factor que permite identificar y caracterizar el tipo de actividad de imagen. (shrink)

This is the fullest existing collection of the texts, for the moment only in Italian translation, with an introduction, notes, general presentation of the texts, various indexes (part of this material is to be found in an attached CD).

Esta investigación se realizó con el objetivo de evaluar el impacto de la pandemia en las expectativas y oportunidades de los jóvenes en la zona metropolitana del Valle de México para seguir estudiando en un contexto de pobreza marcado por la incertidumbre de la COVID-19. El estudio se llevó a cabo con metodología cuantitativa, con alcance descriptivo y correlacional a partir de la definición de tres variables independientes: 1) rango de edad, 2) nivel de estudios, 3) su condición de estudiante; (...) y dos variables dependientes: 1) razón que motiva a los jóvenes a capacitarse; 2) tipo de discriminación. El diseño y análisis fueron trabajados desde teorías sobre pobreza, representaciones sociales y el estado del arte sobre comunicación del COVID-19. Las conclusiones revelan que los jóvenes encuestados encuentran una motivación para aprender en correlación con una mayor preparación; los que poseen estudios universitarios su motivación se centra en mejorar su calidad de vida; mientras que para los de menor nivel de estudios todos los motivos tienen la misma ponderación. En general, las principales motivaciones para aprender se encuentran en el ámbito de la familia, así como influir positivamente en otros. La necesidad de aprender como requisito, para obtener comida o un apoyo económico, y para cuidar de la comunidad, resultan tener la menor frecuencia de motivación, lo que demuestra que las políticas económicas implementadas por el Estado, no han generado las representaciones sociales y culturales suficientes para el progreso integral de las personas. (shrink)

The dominating theologian in Europe between Thomas Aquinas and John Duns Scotus, Henry of Ghent produced a massive Summa of Ordinary Questions as well as fifteen quodlibets during his long tenure at the University of Paris. His work constituted a new synthesis of faith and reason which competed with that of Thomas Aquinas and influenced the history of both philosophy and theology. The first five articles of the Summa, dealing with various issues associated with human knowledge, constitute an adequate introduction (...) to Henry's thought. In them we find his approach to fundamental principles and themes developed in detail in the rest of his corpus. Of the five, only article one has appeared as a whole in English translation. The next four articles reinforce and develop the findings of the first article, providing additional treatments that indicate Henry's principles and orientation. In fact, these four articles alone provide a condensed but remarkably rich portrait of Henry's basic thought, and so are an invaluable resource for beginning and advanced students alike. Articles 2-5 include important positions on knowledge and reality, a conception of humanity's ultimate purpose and the pursuits most conducive to it, and an approach to faith and reason. These four articles are presented here for the first time in English translation with an introduction and notes. Along with the translation, the volume includes the Latin text of the modern critical edition. --Book cover. (shrink)

A principios del siglo XVII, Johannes Kepler estudió el ojo humano como instrumento óptico. Décadas más tarde, René Descartes propuso un experimento para aproximarse al ojo como si fuese un objeto separado por completo del cuerpo. Tomado como analogía de la cámara oscura, el ojo exterior ayudaría a entender la visión humana, a explicar la refracción de la luz y a modelar mejores instrumentos ópticos. Ese ojo exterior ampliaría asimismo la observación y exploración estética de la luz. El ojo objetualizado, (...) desprendido del cuerpo humano, se convertía en materia de estudio a disposición de un observador todavía completamente corporeizado. En este extrañamiento, el ojo técnico y el ojo orgánico se observan y modelan el uno al otro. (shrink)

In this article, I offer a methodological analysis of the empirical research on the causal effects of trade liberalisation, and assess whether such studies can be of any use for guiding policy prescriptions in real-world economies. The analysis focuses on the mainstream economic research that has been used to support arguments in favour of trade liberalisation during the last decades. Even though there are empirical results that could be taken as valid evidence for a causal connection between free trade and (...) economic gains, none of the existing evidence licences trustworthy inferences about the policy effectiveness of trade liberalisation reforms in real-world cases. There are three aspects of the empirical literature that make it highly problematic for making reliable policy inferences: (a) the criteria used to define the notion of ‘free trade’, (b) the background assumptions embedded in the econometric techniques used for estimating causal effects, and (c) the widespread desire among academic economists to attain scientific results in terms of universally valid generalisations. The analysis exposes a worrisome mismatch between, on the one hand, the research aims and outcomes of scientific economics and, on the other, the kind of evidence that would be useful for guiding actual policy deliberations. (shrink)

Este texto propone una defensa de la crítica que Cohen realiza al concepto de propiedad de uno mismo. Para ello, presentaremos la crítica de Cohen a dicho concepto en la obra de Nozick. Luego, se expondrá la defensa elaborada por Mack de la propiedad de uno mismo en la obra de Nozick, por medio de la formulación de lo que denomina “cláusula de propiedad de uno mismo”. Por último, se sostendrá que dicha cláusula no permite superar las críticas de Cohen, (...) debido a que su cumplimiento es compatible con un régimen de propiedad colectiva. (shrink)

El artículo desarrolla el estado de la cuestión respecto a los elementos de la práctica deportiva que influyen en la producción de emociones. Se focaliza la selección bibliográfica desde la perspectiva teórica y metodológica procedente de la sociología y la psicología social. En las conclusiones se muestra que la frecuencia de la práctica deportiva, el grado de interacción y la presencia de competición son los principales factores que influyen en la producción emocional.

Resumen Este artículo tiene como objetivo analizar el debate filosófico entre Ernst Cassirer y Martin Heidegger en el periodo de entreguerras, a partir de su modo disímil de comprender la libertad del hombre como proceso de autoconfiguración del sujeto o Dasein. En primer lugar, se examinará la reinterpretación global de la filosofía kantiana por parte de ambos pensadores a la luz de sus proyectos filosóficos: en el caso de Cassirer, la filosofía de las formas simbólicas, en el de Heidegger, la (...) hermenéutica de la facticidad. En segundo lugar, se analizarán sus interpretaciones sobre el pensamiento estético de Friedrich Schiller, en el marco de sus reflexiones sobre la función del arte para la comprensión de la Selbstbildung. Ello permitirá iluminar un nuevo aspecto de esta disputa, así como determinar la distancia entre sus dos orientaciones filosóficas y políticas.This paper aims to analyze the philosophical debate between Ernst Cassirer and Martin Heidegger in the interwar period, starting from their dissimilar way of understanding human freedom as a process of selfconfiguration of the subject or Dasein. First, we will examine the global reinterpretation of Kantian philosophy by both thinkers in the light of their philosophical projects: in the case of Cassirer, the philosophy of symbolic forms, in the case of Heidegger, the hermeneutics of facticity. Second, their interpretations of the aesthetic thought of Friedrich Schiller will be analyzed, within the framework of their reflections on the function of art for the understanding of the Selbstbildung. This will illuminate a new aspect of this debate and determine the distance between their two philosophical and political orientations. (shrink)