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  1.  32
    ‘No Time to Be Lost!’: Ethical Considerations on Consent for Inclusion in Emergency Pharmacological Research in Severe Traumatic Brain Injury in the European Union.Erwin J. O. Kompanje - 2007 - Science and Engineering Ethics 13 (3):371-381.
    Severe Traumatic Brain Injury (TBI) remains a major cause of death and disability afflicting mostly young adult males and elderly people, resulting in high economic costs to society. Therapeutic approaches focus on reducing the risk on secondary brain injury. Specific ethical issues pertaining in clinical testing of pharmacological neuroprotective agents in TBI include the emergency nature of the research, the incapacity of the patients to informed consent before inclusion, short therapeutic time windows, and a risk-benefit ratio based on concept that (...)
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  2.  30
    Obtaining Consent for Organ Donation From a Competent ICU Patient Who Does Not Want to Live Anymore and Who is Dependent on Life-Sustaining Treatment; Ethically Feasible?Jelle L. Epker, Yorick J. De Groot & Erwin J. O. Kompanje - 2013 - Clinical Ethics 8 (1):29-33.
    We anticipate a further decline of patients who eventually will become brain dead. The intensive care unit (ICU) is considered a last resort for patients with severe and multiple organ dysfunction. Patients with primary central nervous system failure constitute the largest group of patients in which life-sustaining treatment is withdrawn. Almost all these patients are unconscious at the moment physicians decide to withhold and withdraw life-sustaining measures. Sometimes, however competent ICU patients state that they do not want to live anymore (...)
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    How Do 66 European Institutional Review Boards Approve One Protocol for an International Prospective Observational Study on Traumatic Brain Injury? Experiences From the CENTER-TBI Study.Marjolein Timmers, Jeroen T. J. M. van Dijck, Roel P. J. van Wijk, Valerie Legrand, Ernest van Veen, Andrew I. R. Maas, David K. Menon, Giuseppe Citerio, Nino Stocchetti & Erwin J. O. Kompanje - 2020 - BMC Medical Ethics 21 (1):1-14.
    Background The European Union aims to optimize patient protection and efficiency of health-care research by harmonizing procedures across Member States. Nonetheless, further improvements are required to increase multicenter research efficiency. We investigated IRB procedures in a large prospective European multicenter study on traumatic brain injury, aiming to inform and stimulate initiatives to improve efficiency. Methods We reviewed relevant documents regarding IRB submission and IRB approval from European neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury. (...)
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