How long new biomedical technologies are welcome paths for treatment of diseases or reduction of sufferings and where does the aspiration of human enhancement start? Are there basic criteria and standards for a demarcation or has this question to be answered pragmatically, based on a deliberated experience, open for the respective situation? In any case, a common understanding about boundary lines between elemental self-development and forced self-optimization is essential. The volume contains contributions to this burning issue given and debated during (...) the Berlin conference of the Protestant Research Academy (Evangelische Forschungsakademie) in January 2018 to stimulate a public discourse beyond pure scientific discussions. (shrink)