A team of US researchers recently reported the design, assembly and in vivo functionality of a synthetic chromosome III (SynIII) for the yeast Saccharomyces cerevisiae. The synthetic chromosome was assembled bottom‐up from DNA oligomers by teams of students working over several years with researchers as the first part of an international synthetic yeast genome project. Embedded into the sequence of the synthetic chromosome are multiple design changes that include a novel in‐built recombination scheme that can be induced to catalyse intra‐chromosomal (...) rearrangements in a variety of different conditions. This system, along with the other synthetic sequence changes, is intended to aid researchers develop a deeper understanding of how genomes function and find new ways to exploit yeast in future biotechnologies. The landmark of the first synthesised designer eukaryote chromosome, and the power of its massively parallel recombination system, provide new perspectives on the future of synthetic biology and genome research. (shrink)

Publication date: 27 August 2018 Source: Author: Dejana Pavlović, Ivana S. Domazet, Milena Lazić The high rate of youth unemployment is an issue that is largely present in developing countries, such as Serbia. The results of the research will provide a major contribution whether education has an impact on the labour market among young people in Serbia. Decision tree was performed to identify impact constructs. In order to define public policies, an insight is provided into the characteristics of young (...) people that largely contribute to the probability of being employed. The results showed that education has an impact on youth unemployment. Results of the research will be useful for decision makers in the implementation of a strategic model of the labour market. Theoretical and practical implications are discussed in the paper. (shrink)

The radical redefinition of the landscape of physics that followed the contributions of Niels Bohr and Werner Heisenberg at the start of the 20th century led to plethora [of] new perspectives on age-old metaphysical questions on determinism and the nature of reality. The main contention of this article is that the work of Gilbert Simondon - whose magnum opus possesses a scope uniting the most basic philosophical concerns with the most recent breakthroughs in natural sciences - is highly relevant for (...) an adequate understanding of the split between determinism and indeterminism, as well as the underlying presuppositions which have driven some influential contributions to this topic. To this end, the article shows that the more deterministic interpretation of quantum mechanics offered by David Bohm and Louis de Broglie proves to be a valuable reference point for a more precise use and understanding of Simondon'ss transductive logic - especially when its philosophical lapses are considered closely. Finally, following the considerations of both thinkers, we aim at a more precise reconsideration of the stakes of indeterminism in modern physics, as well as a restructuration of what is often understood as a polarization. (shrink)