In his final book, renowned philosopher Pierre Hadot explores Goethe’s relationship with ancient spiritual exercises—transformative acts of intellect, imagination, or will. Goethe sought both an intense experience of the present moment as well as a kind of cosmic consciousness, both of which are rooted in ancient philosophical practices. These practices shaped Goethe’s audacious contrast to the traditional maxim memento mori (Don’t forget that you will die) with the aim of transforming our ordinary consciousness. Ultimately, Hadot reveals how Goethe cultivated a (...) deep love for life that brings to the forefront a new maxim: Don’t forget to live. (shrink)

Traces the development of the idea of experience (Greek peira, empeiria) in Greek thought, from its origins in the Presocratics, through Aristotle and subsequent Peripatetics (Theophrastus, Alexander of Aphrodisias), to Galen. Particular emphasis is placed on the ideas of the medical school of the Empirics, who based their theory and practice on experience and memory. This experience-based epistemology can be traced back to the “epistemic modesty” characteristic of Archaic Greek thought. Some passages in Avicenna, redolent of Sufism, which react to (...) perceived shortcomings in the Aristotelian theory of cognition and demonstration (especially the ineffability of individuals) may have been influenced by the medical Empirist tradition. This emphasis on experience, shared by Archaic Greek thought, medical Empirism, and by certain aspects of Buddhism, may have influenced Islamic Sufism, and hence the thought of Avicenna and his successors. (shrink)

Single‐stranded DNA binding proteins have been known for some time to be crucial in many DNA metabolic reactions in both prokaryotes and eukaryotes. Despite a wealth of studies on these proteins we still do not understand their biochemical mechanism of action. Recent studies of the Escherichia coli single stranded DNA binding protein (SSB) are beginning to provide some insight into how this and similar proteins might function.

The author argues that ancient Skepticism may be most suited to deal with two crises in the Age of COVID-19: both the physical or epidemiological aspects of the pandemic, and the epistemological and ethical crisis of increasing disbelief in the sciences. Following Michel Bitbol, I suggest one way to mitigate this crisis of faith may be for science to become more epistemically modest, renouncing some of its claims to describe reality as it objectively is, and adopting an “intransitive” rather than (...) a “transitive” approach to Nature. This was the attitude adopted by the Greco-Roman medical school of the Empirics, which may also be of assistance in combatting the urgent problem of Fake News. The epistemology of Skepticism and the scientific methodology of the closely related Medical Empiricism shows that an epistemically modest, non-interventionist approach to science is quite compatible with a robust and sophisticated proto-experimental scientific methodology. (shrink)