Background In the course of the COVID-19 pandemic, the biomedical research community’s attempt to focus the attention on fighting COVID-19, led to several challenges within the field of research ethics. However, we know little about the practical relevance of these challenges for Research Ethics Committees. Methods We conducted a qualitative survey across all 52 German RECs on the challenges and potential solutions with reviewing proposals for COVID-19 studies. We de-identified the answers and applied thematic text analysis for the extraction and (...) synthesis of challenges and potential solutions that we grouped under established principles for clinical research ethics. Results We received an overall response rate of 42%. The 22 responding RECs reported that they had assessed a total of 441 study proposals on COVID-19 until 21 April 2020. For the review of these proposals the RECs indicated a broad spectrum of challenges regarding social value, scientific validity, favourable risk–benefit ratio, informed consent, independent review, fair selection of trial participants, and respect for study participants. Mentioned solutions ranged from improved local/national coordination, over guidance on modified consent procedures, to priority setting across clinical studies. Conclusions RECs are facing a broad spectrum of pressing challenges in reviewing COVID-19 studies. Some challenges for consent procedures are well known from research in intensive care settings but are further aggravated by infection measures. Other challenges such as reviewing several clinical studies at the same time that potentially compete for the recruitment of in-house COVID-19 patients are unique to the current situation. For some of the challenges the proposed solutions in our survey could relatively easy be translated into practice. Others need further conceptual and empirical research. Our findings together with the increasing body of literature on COVID-19 research ethics, and further stakeholder engagement should inform the development of hands-on guidance for researchers, funders, RECs, and further oversight bodies. (shrink)

The labor market is an area with diverse data structures and multiple applications, such as matching job seekers with the right training or job. For this reason, the multilingual classification of European Skills, Competences, Qualifications and Occupations (ESCO) is a good example of the central role of ontologies in this area. However, ESCO cannot provide all the details of local labor market needs and does not provide links to other hierarchies of competences. For example, other taxonomies of occupations and skills (...) are widely used in German-speaking countries, but they are not in a state where they are easily accessible for interoperability and reasoning. In this paper, we present a first version of a German Labor Market Ontology (GLMO) that uses ESCO as a top-level ontology for the target domain. This makes it highly interoperable and comparable to existing ontologies by providing details for the regional structures in German-speaking countries. In addition, we present a detailed evaluation of the provided data and applications, as well as an extensive discussion of future work. (shrink)

The need to find clarity concerning (1) the relationship between scientific and religious cosmological discourses and (2) the imagining of a space where various religions could meet in fruitful conciliation as far as (1) is concerned, formed the basis of the article. The aim of the article was to investigate the relevance of Buddhaghosa’s Visuddhimagga (5th CE, Pali compendium of Theravāda Buddhism) with regard to the above problems. The methodology employed involved clarifying the historical context of the Visuddhimagga ; understanding (...) the subjective intentions of Buddhaghosa and extrapolating non-emphasised but promising underlying tendencies in his magnum opus, conducive to a perspective of ultimate, universal peace as far as Cosmos, all of humanity and its various religious discourses are concerned. The reading of the Visuddhimagga revealed a mythology of many deities, tolerated but demoted to a status lower than that of enlightened humans; the denial of a Creator God; no notion of an analogia entis between humans and a living Cosmos, nor any tendency towards pantheism and a commitment to the ideal of universal happiness for all beings. The main conclusion was that Theravāda Buddhism (and, to a lesser extent, Christian theology) could be extended towards the notion of a living, evolving Cosmos, appearing from and disappearing into non-substantial silence. It is not claimed that Buddhaghosa succeeded in achieving a great cosmology. It remains an unrealised possibility, latently possible as an extension of Theravāda. Contribution: The contribution of the article is that it uncovers deeply hidden lines in Buddhism (and Christianity) that are emerging and converging. ‘Theo-logy’, re-interpreted as mystical ‘cosmo-sophy’, would not amount to a cynical debunking or irresponsible annexation of Buddhaghosa for utterly unthinkable ends, but as a topic worthy of investigation. The article is part of work in progress. (shrink)