The present study examined the relationship between vital exhaustion, Cloninger's temperament dimensions, and state affects during experimentally induced stress among participants aged 22–37 years. Larsen and Diener's circumplex model of affect was used to structure the self-reported affects. Temperament was measured by the Temperament and Character Inventory. Feelings of exhaustion were assessed by the Maastricht Questionnaire. Stressors used were an aversive startle task, an appetitive mental arithmetic task, and an aversive choice-deadline reaction time task. The results showed that the level (...) of vital exhaustion among healthy persons is related to unpleasant state affects other than state fatigue. Temperament also modified the relationship between vital exhaustion and affects. In addition, vital exhaustion was related to a tendency to behavioural inhibition (harm avoidance). Our findings suggest that temperament is related to feelings of exhaustion and is likely to predispose to negative affectivity when accompanied by exhaustion. (shrink)