Acceptable risks and burdens for children in research without direct benefit: a systematic analysis of the decisions made by the Dutch Central Committee

Journal of Medical Ethics 36 (7):420-424 (2010)
Abstract
Objectives To evaluate whether the requirement of “minimal risk and burden” for paediatric research without direct benefit to the subjects compromises the ability to obtain data necessary for improving paediatric care. To provide evidence-based reflections on the EU recommendation that allows for a higher level of risk. Design and setting Systematic analysis of the approval/rejection decisions made by the Dutch Central Committee on Research involving Human Subjects (CCMO). Review methods The analysis included 165 proposals for paediatric research without direct benefit that were reviewed by the CCMO between January, 2000, and July, 2007. A separate, in-depth analysis of all drug studies included 18 early phase drug studies and nine other drug studies without direct benefit. Results 11 out of 165 studies were definitively rejected because the CCMO did not regard the risk and/or burden to be minimal. In three of these 11 cases (including two early phase drug studies) the requirement of minimal risk and burden was cited as the only reason for rejection. Four other early phase drug studies also involved risks and/or burdens that were not regarded to be minimal but were nevertheless approved. Conclusions The requirement of minimal risk and burden, aiming to protect research subjects, occasionally leads to rejection of protocols. Early phase drug studies relatively often do not comply with the requirement. Committees may find ways to approve important studies that formally should be rejected, but that is not a desirable solution. The regulatory framework should be revised to make such occasional exceptions to the requirement legitimate and transparent
Keywords No keywords specified (fix it)
Categories (categorize this paper)
DOI 10.1136/jme.2010.035550
Options
 Save to my reading list
Follow the author(s)
My bibliography
Export citation
Find it on Scholar
Edit this record
Mark as duplicate
Revision history
Request removal from index
Download options
Our Archive


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 29,511
Through your library
References found in this work BETA

No references found.

Add more references

Citations of this work BETA

Add more citations

Similar books and articles
Risk-Benefit Analysis: From a Logical Point of View. [REVIEW]Georg Spielthenner - 2012 - Journal of Bioethical Inquiry 9 (2):161-170.
Solidarity, Children and Research.Barry Lyons - 2012 - Bioethics 26 (7):369-375.
Understanding Risks and Benefits in Research on Reproductive Genetic Technologies.Janet Malek - 2007 - Journal of Medicine and Philosophy 32 (4):339 – 358.
The Harm-Benefit Tradeoff in "Bad Deal" Trials.Gillian Nycum & Lynette Reid - 2007 - Kennedy Institute of Ethics Journal 17 (4):321-350.
Added to PP index
2010-09-13

Total downloads
7 ( #531,526 of 2,180,710 )

Recent downloads (6 months)
1 ( #301,383 of 2,180,710 )

How can I increase my downloads?

Monthly downloads
My notes
Sign in to use this feature


Discussion
Order:
There  are no threads in this forum
Nothing in this forum yet.

Other forums