8 found
Order:
  1.  31
    Emergence and its place in nature: a case study of biochemical networks.Fred C. Boogerd, Frank J. Bruggeman, Robert C. Richardson, Achim Stephan & Hans V. Westerhoff - 2005 - Synthese 145 (1):131-164.
    We will show that there is a strong form of emergence in cell biology. Beginning with C.D. Broad’s classic discussion of emergence, we distinguish two conditions sufficient for emergence. Emergence in biology must be compatible with the thought that all explanations of systemic properties are mechanistic explanations and with their sufficiency. Explanations of systemic properties are always in terms of the properties of the parts within the system. Nonetheless, systemic properties can still be emergent. If the properties of the components (...)
    Direct download  
     
    Export citation  
     
    Bookmark   54 citations  
  2.  74
    Systems Biology: Philosophical Foundations.Fred C. Boogerd, Frank J. Bruggeman, Jan-Hendrik S. Hofmeyr & Hans V. Westerhoff (eds.) - 2007 - Elsevier.
    Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecendented in its combination of biology with a ...
    Direct download  
     
    Export citation  
     
    Bookmark   17 citations  
  3.  42
    Towards philosophical foundations of Systems Biology: introduction.Fred C. Boogerd, Frank J. Bruggeman, Jan-Hendrik S. Hofmeyr & Hans V. Westerhoff - 2007 - In Fred C. Boogerd, Frank J. Bruggeman, Jan-Hendrik S. Hofmeyr & Hans V. Westerhoff (eds.), Systems Biology: Philosophical Foundations. Elsevier.
  4.  68
    Mechanistic Explanations and Models in Molecular Systems Biology.Fred C. Boogerd, Frank J. Bruggeman & Robert C. Richardson - 2013 - Foundations of Science 18 (4):725-744.
  5.  22
    Systems Biology: at last an integrative wet and dry Biology.Frank J. Bruggeman - 2007 - Biological Theory 2 (2):183-188.
    The progress of the molecular biosciences has been so enormous that a discipline studying how cellular functioning emerges out of the behaviors of their molecular constituents has become reality. Systems biology studies cells as spatiotemporal networks of interacting molecules using an integrative approach of theory , experimental biology , and quantitative network-wide analytical measurement . Its aim is to understand how molecules jointly bring about life. Systems biology is rapidly discovering principles governing the functioning of molecular networks and methods to (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   3 citations  
  6. Macromolecular intelligence in microorganisms. [REVIEW]Frank J. Bruggeman, Wally C. Van Heeswijk, Fred Boogerd & Hans V. Westerhoff - 2000 - Biological Chemistry 381:965-972.
    Biochemistry and molecular biology have been focusing on the structural, catalytic, and regulatory proper- ties of individual macromolecules from the perspective of clarifying the mechanisms of metabolism and gene expression. Complete genomes of ‘primitive’ living organisms seem to be substantially larger than necessary for metabolism and gene expression alone. This is in line with the findings of silent phenotypes for supposedly important genes, apparent redundancy of functions, and variegated networks of signal transduction and transcription factors. Here we propose that evolutionary (...)
     
    Export citation  
     
    Bookmark  
  7.  22
    Afterthoughts as foundations for systems biology.Fred C. Boogerd, Frank J. Bruggeman, Jan-Hendrik S. Hofmeyr & Hans V. Westerhoff - 2007 - In Fred C. Boogerd, Frank J. Bruggeman, Jan-Hendrik S. Hofmeyr & Hans V. Westerhoff (eds.), Systems Biology: Philosophical Foundations. Elsevier.
  8.  5
    Multi-tasking of biosynthetic and energetic functions of glycolysis explained by supply and demand logic.Johan H. van Heerden, Frank J. Bruggeman & Bas Teusink - 2015 - Bioessays 37 (1):34-45.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark