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  1. added 2019-01-21
    Culture and the Trajectories of Developmental Pathology: Insights From Control and Information Theories.Rodrick Wallace - 2018 - Acta Biotheoretica 66 (2):79-112.
    Cognition in living entities -- and their social groupings or institutional artifacts -- is necessarily as complicated as their embedding environments, which, for humans, includes a particularly rich cultural milieu. The asymptotic limit theorems of information and control theories permit construction of a new class of empirical 'regression-like' statistical models for cognitive developmental processes, their dynamics, and modes of dysfunction. Such models may, as have their simpler analogs, prove useful in the study and remediation of cognitive failure at and across (...)
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  2. added 2019-01-14
    How to Use Fitness Landscape Models for the Analysis of Collective Decision-Making: A Case of Theory-Transfer and its Limitations.Peter Marks, Lasse Gerrits & Johannes Marx - 2019 - Biology and Philosophy 34 (1):7.
    There is considerable correspondence between theories and models used in biology and the social sciences. One type of model that is in use in both biology and the social sciences is the fitness landscape model. The properties of the fitness landscape model have been applied rather freely in the social domain. This is partly due to the versatility of the model, but it is also due to the difficulties of transferring a model to another domain. We will demonstrate that in (...)
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  3. added 2019-01-14
    Importance of Initial Concentration of Factor VIII in a Mechanistic Model of In Vitro Coagulation.M. Susree & M. Anand - 2018 - Acta Biotheoretica 66 (3):201-212.
    This computational study generates a hypothesis for the coagulation protein whose initial concentration greatly influences the course of coagulation. Many clinical malignancies of blood coagulation arise due to abnormal initial concentrations of coagulation factors. Sensitivity analysis of mechanistic models of blood coagulation is a convenient method to assess the effect of such abnormalities. Accordingly, the study presents sensitivity analysis, with respect to initial concentrations, of a recently developed mechanistic model of blood coagulation. Both the model and parameters to which model (...)
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  4. added 2019-01-14
    A Credible-World Account of Biological Models.Sim-Hui Tee - 2018 - Axiomathes 28 (3):309-324.
    In a broad brush, biological models are often constructed in two general types: as a concrete model; as an abstract model. A concrete model is a material model such as model organisms, while an abstract model is a mathematical or computational model consists of equations or algorithms. Though there are types of biological models that cannot be strictly categorized as either concrete or abstract, they are falling somewhere in between this spectrum. In view of the fact that biological phenomena are (...)
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  5. added 2019-01-14
    Descriptive Modeling of the Dynamical Systems and Determination of Feedback Homeostasis at Different Levels of Life Organization.G. N. Zholtkevych, K. V. Nosov, Yu G. Bespalov, L. I. Rak, M. Abhishek & E. V. Vysotskaya - 2018 - Acta Biotheoretica 66 (3):177-199.
    The state-of-art research in the field of life’s organization confronts the need to investigate a number of interacting components, their properties and conditions of sustainable behaviour within a natural system. In biology, ecology and life sciences, the performance of such stable system is usually related to homeostasis, a property of the system to actively regulate its state within a certain allowable limits. In our previous work, we proposed a deterministic model for systems’ homeostasis. The model was based on dynamical system’s (...)
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  6. added 2019-01-14
    Correction To: Graphical Representation and Similarity Analysis of DNA Sequences Based on Trigonometric Functions.Guo-Sen Xie, Xiao-Bo Jin, Chunlei Yang, Jiexin Pu & Zhongxi Mo - 2018 - Acta Biotheoretica 66 (3):251-253.
  7. added 2019-01-07
    From Models to Simulations.Franck Varenne - 2018 - London, UK: Routledge.
    This book analyses the impact computerization has had on contemporary science and explains the origins, technical nature and epistemological consequences of the current decisive interplay between technology and science: an intertwining of formalism, computation, data acquisition, data and visualization and how these factors have led to the spread of simulation models since the 1950s. -/- Using historical, comparative and interpretative case studies from a range of disciplines, with a particular emphasis on the case of plant studies, the author shows how (...)
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  8. added 2019-01-07
    Multiple Regression Is Not Multiple Regressions: The Meaning of Multiple Regression and the Non-Problem of Collinearity.Michael B. Morrissey & Graeme D. Ruxton - 2018 - Philosophy, Theory, and Practice in Biology 10 (3).
    Simple regression (regression analysis with a single explanatory variable), and multiple regression (regression models with multiple explanatory variables), typically correspond to very different biological questions. The former use regression lines to describe univariate associations. The latter describe the partial, or direct, effects of multiple variables, conditioned on one another. We suspect that the superficial similarity of simple and multiple regression leads to confusion in their interpretation. A clear understanding of these methods is essential, as they underlie a large range of (...)
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  9. added 2018-12-24
    Adaptive Control Based Harvesting Strategy for a Predator–Prey Dynamical System.Moitri Sen, Ashutosh Simha & Soumyendu Raha - 2018 - Acta Biotheoretica 66 (4):293-313.
    This paper deals with designing a harvesting control strategy for a predator–prey dynamical system, with parametric uncertainties and exogenous disturbances. A feedback control law for the harvesting rate of the predator is formulated such that the population dynamics is asymptotically stabilized at a positive operating point, while maintaining a positive, steady state harvesting rate. The hierarchical block strict feedback structure of the dynamics is exploited in designing a backstepping control law, based on Lyapunov theory. In order to account for unknown (...)
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  10. added 2018-12-24
    Study of the Population Dynamics of Busseola Fusca, Maize Pest.Janvier Pesser Ntahomvukiye, Anatole Temgoua & Samuel Bowong - 2018 - Acta Biotheoretica 66 (4):379-397.
    Busseola fusca is a maize and sorghum pest that can cause significant damage to both crops. Given that maize is one of the main cereals grown in the worldwide, this pest is a major challenge for maize production and therefore for the economies of several countries . In this paper , based on the life cycle of B. fusca, we propose a mathematical model to study the population dynamics of this insect pest . A sensitivity analysis using the eFast method (...)
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  11. added 2018-12-10
    Using Over-Represented Tetrapeptides to Predict Protein Submitochondria Locations.Hao Lin, Wei Chen, Lu-Feng Yuan, Zi-Qiang Li & Hui Ding - 2013 - Acta Biotheoretica 61 (2):259-268.
  12. added 2018-12-09
    Modeling the Molecular Regulatory Mechanism of Circadian Rhythms in Drosophila.Jean-Christophe Leloup & Albert Goldbeter - 2000 - Bioessays 22 (1):84.
    Thanks to genetic and biochemical advances on the molecular mechanism of circadian rhythms in Drosophila, theoretical models closely related to experimental observations can be considered for the regulatory mechanism of the circadian clock in this organism. Modeling is based on the autoregulatory negative feedback exerted by a complex between PER and TIM proteins on the expression of per and tim genes. The model predicts the occurrence of sustained circadian oscillations in continuous darkness. When incorporating light‐induced TIM degradation, the model accounts (...)
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  13. added 2018-12-03
    A Tissue-Level Electromechanical Model Of The Left Ventricle: Application to the Analysis of Intraventricular Pressure.Virginie Le Rolle, Guy Carrault, Pierre-Yves Richard, Philippe Pibarot & Louis-Gilles Durand - 2009 - Acta Biotheoretica 57 (4):457-478.
    The ventricular pressure profile is characteristic of the cardiac contraction progress and is useful to evaluate the cardiac performance. In this contribution, a tissue-level electromechanical model of the left ventricle is proposed, to assist the interpretation of left ventricular pressure waveforms. The left ventricle has been modeled as an ellipsoid composed of twelve mechano-hydraulic sub-systems. The asynchronous contraction of these twelve myocardial segments has been represented in order to reproduce a realistic pressure profiles. To take into account the different energy (...)
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  14. added 2018-12-03
    Organogenesis at the Shoot Apex: An Attempt at Modelization.Herve Le Guyader & Michel Ferre - 1988 - Acta Biotheoretica 37 (1):37-86.
    A geometrical model of the emergence of a primordium at the shoot apex in dicotyledons is proposed. It is based on recent fundamental results on plant morphogenesis, i.e.: the emergence is preceded by the reorganization of the microtubules of the cortical cytoskeleton, leading to a new orientation of the synthesis of the cell wall microfibrils; the resulting global stress is related to the general orientation of the cell growth.So the model sums up the continuous interactions linking the microtubules, the microfibrils (...)
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  15. added 2018-12-03
    Selection Strategies in Concept Attainment as a Function of Number of Persons and Stimulus Display.Patrick R. Laughlin - 1965 - Journal of Experimental Psychology 70 (3):323.
    The selection strategies of individuals and 2-person cooperative groups were investigated in 5 concept-attainment problems. 2 types of stimulus displays were used: (a) form displays, consisting of geometric forms varying in 6 attributes with 2 levels of each, (b) sequence displays, consisting of 6 plus and/or minus signs in a row. The arrangement of cards in the stimulus displays was ordered or random. The principal results were: (a) 2-person groups used the focusing strategy more, required fewer card choices to solution, (...)
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  16. added 2018-11-26
    Mathematical Basis of Predicting Dominant Function in Protein Sequences by a Generic HMM–ANN Algorithm.Siddhartha Kundu - 2018 - Acta Biotheoretica 66 (2):135-148.
    The accurate annotation of an unknown protein sequence depends on extant data of template sequences. This could be empirical or sets of reference sequences, and provides an exhaustive pool of probable functions. Individual methods of predicting dominant function possess shortcomings such as varying degrees of inter-sequence redundancy, arbitrary domain inclusion thresholds, heterogeneous parameterization protocols, and ill-conditioned input channels. Here, I present a rigorous theoretical derivation of various steps of a generic algorithm that integrates and utilizes several statistical methods to predict (...)
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  17. added 2018-11-25
    Lateral and Vertical Transfer in Biology, Linguistics and Anthropology - An Account of Widely Neglected Ideas in the Formation of Evolutionary Theories.Frank Kressing & Matthis Krischel - unknown
    Models of biological and cultural evolution that developed from the 19th century onward are characterized by two main features:They were mostly centered on the unilinear transmission of cultural and biological replicators, and They were centered on phylogenetic images of descent, that means, specifically, the tree of life and the tree of languages metaphors. The purpose of this paper is to show that theories of unilinear descent in biology, linguistics and anthropology represent just one among several approaches in explain evolutionary development (...)
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  18. added 2018-11-24
    Theoretical Assessment of the Impact of Climatic Factors in a Vibrio Cholerae Model.G. Kolaye, I. Damakoa, S. Bowong, R. Houe & D. Békollè - 2018 - Acta Biotheoretica 66 (4):279-291.
    A mathematical model for Vibrio Cholerae (V. Cholerae) in a closed environment is considered, with the aim of investigating the impact of climatic factors which exerts a direct influence on the bacterial metabolism and on the bacterial reservoir capacity. We first propose a V. Cholerae mathematical model in a closed environment. A sensitivity analysis using the eFast method was performed to show the most important parameters of the model. After, we extend this V. cholerae model by taking account climatic factors (...)
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  19. added 2018-11-24
    The Trans-Gompertz Function: An Alternative to the Logistic Growth Function with Faster Growth.F. Kozusko & M. Bourdeau - 2015 - Acta Biotheoretica 63 (4):397-405.
    The growth characteristics of the recently derived Trans-Gompertz function are compared to those of the Generalized Logistic function. Both functions are defined by one shaping parameter and one rate parameter. The functions are matched at a specified point on the growth curve by equating both the first and second derivatives. Analysis shows that the matched Trans-Gompertz function will have grown at a faster rate with a larger inflection point ratio.
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  20. added 2018-11-24
    Necrotic Tumor Growth: An Analytic Approach.Martin Kohlmann - 2012 - Acta Biotheoretica 60 (3):273-287.
    The present paper deals with a free boundary problem modeling the growth process of necrotic multi-layer tumors. We prove the existence of flat stationary solutions and determine the linearization of our model at such an equilibrium. Finally, we compute the solutions of the stationary linearized problem and comment on bifurcation.
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  21. added 2018-11-19
    Effects of Vole Fluctuations on the Population Dynamics of the Barn Owl Tyto Alba.Chris Klok & Andre Roos - 2007 - Acta Biotheoretica 55 (3):227-241.
    Many predator species feed on prey that fluctuates in abundance from year to year. Birds of prey can face large fluctuations in food abundance i.e. small mammals, especially voles. These annual changes in prey abundance strongly affect the reproductive success and mortality of the individual predators and thus can be expected to influence their population dynamics and persistence. The barn owl, for example, shows large fluctuations in breeding success that correlate with the dynamics in voles, their main prey species. Analysis (...)
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  22. added 2018-11-19
    Analysing Population Numbers of the House Sparrow in the Netherlands With a Matrix Model and Suggestions for Conservation Measures.Chris Klok, Remko Holtkamp, Rob Apeldoorn, Marcel E. Visser & Lia Hemerik - 2006 - Acta Biotheoretica 54 (3):161-178.
    The House Sparrow (Passer domesticus), formerly a common bird species, has shown a rapid decline in Western Europe over recent decades. In The Netherlands, its decline is apparent from 1990 onwards. Many causes for this decline have been suggested that all decrease the vital rates, i.e. survival and reproduction, but their actual impact remains unknown. Although the House Sparrow has been dominant in The Netherlands, data on life history characteristics for this bird species are scarce: data on reproduction are non-existent, (...)
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  23. added 2018-11-19
    An Architecture for Animal-Like Behavior Selection.Tadashi Kitamura - 2001 - In T. Kitamura (ed.), What Should Be Computed to Understand and Model Brain Function? World Scientific. pp. 3--23.
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  24. added 2018-11-18
    A 3D Individual-Based Model to Study Effects of Chemotaxis, Competition and Diffusion on the Motile-Phytoplankton Aggregation.Ilhem Bouderbala, Nadjia El Saadi, Alassane Bah & Pierre Auger - 2018 - Acta Biotheoretica 66 (4):257-278.
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  25. added 2018-11-18
    HIV Transmissions by Stage and Sex Role in Long-Term Concurrent Sexual Partnerships.Jong-Hoon Kim - 2015 - Acta Biotheoretica 63 (1):33-54.
    Most mathematical models used to examine the role of different stages of human immunodeficiency virus infection unrealistically assume that HIV is transmitted through one-off contacts or that transmission rates are the same between males and females. We sought to examine whether inferences from previous models are robust to the relaxation of those unrealistic assumptions. We developed a model of HIV transmissions through sexual partnerships assuming that sexual partnerships have variable duration, sexual partnerships are concurrent, and the male-to-female transmission rate is (...)
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  26. added 2018-11-18
    Reversible Adaptive Trees.Yannick Kergosien - 2013 - Acta Biotheoretica 61 (3):413-424.
    We describe reversible adaptive trees, a class of stochastic algorithms modified from the formerly described adaptive trees. They evolve in time a finite subset of an ambient Euclidean space of any dimension, starting from a seed point and, accreting points to the evolving set, they grow branches towards a target set which can depend on time. In contrast with plain adaptive trees, which were formerly proven to have strong convergence properties to a static target, the points of reversible adaptive trees (...)
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  27. added 2018-11-18
    Heart Rate Regulation Processed Through Wavelet Analysis and Change Detection: Some Case Studies.Nadia Khalfa, Pierre Bertrand, Gil Boudet, Alain Chamoux & Véronique Billat - 2012 - Acta Biotheoretica 60 (1-2):109-129.
    Heart rate variability is an indicator of the regulation of the heart, see Task Force :1043–1065, 1996). This study compares the regulation of the heart in two cases of healthy subjects within real life situations: Marathon runners and shift workers. After an update on the state of the art on HRV processing, we specify our probabilistic model: We choose modeling heartbeat series by locally stationary Gaussian process . HRV is then processed by the combination of two statistical methods: Continuous wavelet (...)
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  28. added 2018-11-12
    The Statistical Theory of Global Population Growth.Sergey P. Kapitza - 2003 - In J. B. Nation (ed.), Formal Descriptions of Developing Systems. Kluwer Academic Publishers. pp. 11--35.
    Of all global problems world population growth is the most significant. The growth of the number of people expresses the sum outcome of all economic, social and cultural activities that comprise human history. Demographic data in a concise and quantitative way describe this process in the past and present. By applying the concepts of nonlinear dynamics and synergetics, it is possible to work out a mathematical model for a phenomenological description of the global demographic process and project its trends into (...)
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  29. added 2018-11-11
    Complex Dynamics of an SIR Epidemic Model with Saturated Incidence Rate and Treatment.Soovoojeet Jana, Swapan Kumar Nandi & T. K. Kar - 2016 - Acta Biotheoretica 64 (1):65-84.
    This paper describes a traditional SIR type epidemic model with saturated infection rate and treatment function. The dynamics of the model is studied from the point of view of stability and bifurcation. Basic reproduction number is obtained and it is shown that the model system may possess a backward bifurcation. The global asymptotic stability of the endemic equilibrium is studied with the help of a geometric approach. Optimal control problem is formulated and solved. Some numerical simulation works are carried out (...)
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  30. added 2018-11-11
    A Simulation Study for the Distribution Law of Relative Moments of Evolution.Lorentz Jäntschi, Sorana D. Bolboacă & Radu E. Sestraş - 2012 - Complexity 17 (6):52-63.
    Nine selection‐survival strategies were implemented in a genetic algorithm experiment, and differences in terms of evolution were assessed. The moments of evolution (expressed as generation numbers) were recorded in a contingency of three strategies (i.e., proportional, tournament, and deterministic) for two moments (i.e., selection for crossover and mutation and survival for replacement). The experiment was conducted for the first 20,000 generations in 46 independent runs. The relative moments of evolution (where evolution was defined as a significant increase in the determination (...)
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  31. added 2018-11-11
    Genetic and Environmental Influences on Behavior: Capturing All the Interplay.Wendy Johnson - 2007 - Psychological Review 114 (2):423-440.
    Basic quantitative genetic models of human behavioral variation have made clear that individual differences in behavior cannot be understood without acknowledging the importance of genetic influences. Yet these basic models estimate average, population-level genetic and environmental influences, obscuring differences that might exist within the population and masking systematic transactions between specific genetic and environmental influences. This article discusses a newer, more sophisticated and powerful quantitative genetic model that articulates these transactions. Results from this model highlight the ways in which the (...)
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  32. added 2018-11-10
    On the Evolution of Decoys in Plant Immune Systems.Iaroslav Ispolatov & Michael Doebeli - 2010 - Biological Theory 5 (3):256-263.
    The guard-guardee model for plant immunity describes how resistance proteins in host cells monitor host target proteins that are manipulated by pathogen effector proteins. A recently suggested extension of this model includes decoys, which are duplicated copies of guardee proteins, and have the sole function to attract the effector and, when modified by the effector, trigger the plant immune response. Here we present a proof-of-principle model for the functioning of decoys in plant immunity, quantitatively developing this experimentally derived concept. Our (...)
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  33. added 2018-11-05
    Introduction: The Plurality of Modeling.Philippe Huneman & Maël Lemonie - 2014 - History and Philosophy of the Life Sciences 36 (1):5-15.
    Philosophers of science have recently focused on the scientific activity of modeling phenomena, and explicated several of its properties, as well as the activities embedded into it. A first approach to modeling has been elaborated in terms of representing a target system: yet other epistemic functions, such as producing data or detecting phenomena, are at least as relevant. Additional useful distinctions have emerged, such as the one between phenomenological and mechanistic models. In biological sciences, besides mathematical models, models now come (...)
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  34. added 2018-11-05
    Mapping an Expanding Territory: Computer Simulations in Evolutionary Biology.Philippe Huneman - 2014 - History and Philosophy of the Life Sciences 36 (1):60-89.
    The pervasive use of computer simulations in the sciences brings novel epistemological issues discussed in the philosophy of science literature since about a decade. Evolutionary biology strongly relies on such simulations, and in relation to it there exists a research program (Artificial Life) that mainly studies simulations themselves. This paper addresses the specificity of computer simulations in evolutionary biology, in the context (described in Sect. 1) of a set of questions about their scope as explanations, the nature of validation processes (...)
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  35. added 2018-11-05
    Introduction: The Plurality of Modeling.Huneman Philippe & Lemoine Maël - 2014 - History and Philosophy of the Life Sciences 36 (1):5-15.
    Philosophers of science have recently focused on the scientific activity of modeling phenomena, and explicated several of its properties, as well as the activities embedded into it. A first approach to modeling has been elaborated in terms of representing a target system: yet other epistemic functions, such as producing data or detecting phenomena, are at least as relevant. Additional useful distinctions have emerged, such as the one between phenomenological and mechanistic models. In biological sciences, besides mathematical models, models now come (...)
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  36. added 2018-11-05
    Mapping an Expanding Territory: Computer Simulations in Evolutionary Biology.Philippe Huneman - 2014 - History and Philosophy of the Life Sciences 36 (1):60-89.
  37. added 2018-11-05
    Introduction: The Plurality of Modeling.Huneman Philippe & Lemoine Maël - 2014 - History and Philosophy of the Life Sciences 36 (1):5-15.
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  38. added 2018-11-02
    Stereochemical Recognition in Nucleic Acid-Amino Acid Interactions and its Implications in Biological Coding: A Model Approach.Lawrence B. Hendry & Francis H. Witham - 1979 - Perspectives in Biology and Medicine 22 (3):333-345.
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  39. added 2018-10-22
    Modeling Mechanisms.Stuart Glennan - 2005 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 36 (2):443-464.
    Philosophers of science increasingly believe that much of science is concerned with understanding the mechanisms responsible for the production of natural phenomena. An adequate understanding of scientific research requires an account of how scientists develop and test models of mechanisms. This paper offers a general account of the nature of mechanical models, discussing the representational relationship that holds between mechanisms and their models as well as the techniques that can be used to test and refine such models. The analysis is (...)
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  40. added 2018-10-21
    On the Neural Enrichment of Economic Models: Recasting the Challenge.Roberto Fumagalli - 2017 - Biology and Philosophy 32 (2):201-220.
    In a recent article in this Journal, Fumagalli argues that economists are provisionally justified in resisting prominent calls to integrate neural variables into economic models of choice. In other articles, various authors engage with Fumagalli’s argument and try to substantiate three often-made claims concerning neuroeconomic modelling. First, the benefits derivable from neurally informing some economic models of choice do not involve significant tractability costs. Second, neuroeconomic modelling is best understood within Marr’s three-level of analysis framework for information-processing systems. And third, (...)
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  41. added 2018-10-21
    Implementation of a Model of Bodily Fluids Regulation.Julie Fontecave-Jallon & S. Randall Thomas - 2015 - Acta Biotheoretica 63 (3):269-282.
    The classic model of blood pressure regulation by Guyton et al. (Annu Rev Physiol 34:13–46, 1972a; Ann Biomed Eng 1:254–281, 1972b) set a new standard for quantitative exploration of physiological function and led to important new insights, some of which still remain the focus of debate, such as whether the kidney plays the primary role in the genesis of hypertension (Montani et al. in Exp Physiol 24:41–54, 2009a; Exp Physiol 94:382–388, 2009b; Osborn et al. in Exp Physiol 94:389–396, 2009a; Exp (...)
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  42. added 2018-10-15
    Egg Distributions of Insect Parasitoids: Modelling and Analysis of Temporal Data with Host Density Dependence.John Fenlon, Malcolm Faddy, Menia Toussidou & Michael Courcy Williams - 2009 - Acta Biotheoretica 57 (3):309-320.
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  43. added 2018-10-15
    Egg Distributions of Insect Parasitoids: Modelling and Analysis of Temporal Data with Host Density Dependence.John S. Fenlon, Malcolm J. Faddy, Menia Toussidou & Michael E. de Courcy Williams - 2009 - Acta Biotheoretica 57 (3):309-320.
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  44. added 2018-10-13
    Why One Model is Never Enough: A Defense of Explanatory Holism.Hochstein Eric - 2017 - Biology and Philosophy 32 (6):1105-1125.
    Traditionally, a scientific model is thought to provide a good scientific explanation to the extent that it satisfies certain scientific goals that are thought to be constitutive of explanation. Problems arise when we realize that individual scientific models cannot simultaneously satisfy all the scientific goals typically associated with explanation. A given model’s ability to satisfy some goals must always come at the expense of satisfying others. This has resulted in philosophical disputes regarding which of these goals are in fact necessary (...)
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  45. added 2018-10-13
    Modeling Heterogeneity in the Pluripotent State: A Promising Strategy for Improving the Efficiency and Fidelity of Stem Cell Differentiation.Vladimir Espinosa Angarica & Antonio del Sol - 2016 - Bioessays 38 (8):758-768.
    Pluripotency can be considered a functional characteristic of pluripotent stem cells (PSCs) populations and their niches, rather than a property of individual cells. In this view, individual cells within the population independently adopt a variety of different expression states, maintained by different signaling, transcriptional, and epigenetics regulatory networks. In this review, we propose that generation of integrative network models from single cell data will be essential for getting a better understanding of the regulation of self‐renewal and differentiation. In particular, we (...)
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  46. added 2018-10-13
    Computer-Mediated Communication in Biology.Marcella Faria - 2008 - American Journal of Semiotics 24 (1/3):125-144.
    Increasingly, biologists are using computers to model and to create biological representations. However, the exponential growth in available biological dataposes a challenge for experimental and theoretical researchers in both Biology and in Computer Science. In short, when even the simple retrieval of relevant biological information for a researcher becomes a complex task — its analysis and synthesis with other biological information will become even more daunting and unlikely. In this context, specially organized ‘structures of representation’ are needed for the efficient (...)
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  47. added 2018-10-13
    As Well as Physiological States, Pathological States and Therapeutical Problems May Be a Gushing Spring for Biological Theory - and Conversely. E. Bernard-Weil, F. Mikol, M. Monge-Strauss & P. Jung - 1999 - Acta Biotheoretica 47 (3-4):281-307.
    New class of therapies, including bipolar therapies and “paradoxical” unipolar therapies were firstly proposed in relation to a clinical insight and to some results of biological investigations, then they gave rise to mathematical modeling which brought a justification of these therapies, at least from a theoretical point of view. After recalling the mathematical model for the regulation of agonistic antagonistic couples, and reporting the fundamental types of control simulation by means of it, we point out the validity of therapeutical applications (...)
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  48. added 2018-10-13
    How Good Are Formal Neurons for Modelling Real Ones? E. Miranda - 1997 - Acta Biotheoretica 45 (2):171-179.
    A formal neuron has been studied mathematically. The spiking behaviour of a single neuron has been considered and the influence of the other neurons has been replaced by an average activity level. Four different kinds of spiking behaviour are predicted by the model: B, C, P and S neurons and several real neurons can be classified within these four categories. Some properties of the spiking neuron are calculated: 1) the time between spikes, 2) the spike train length and 3) the (...)
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  49. added 2018-10-11
    Quaternion-Based Texture Analysis of Multiband Satellite Images: Application to the Estimation of Aboveground Biomass in the East Region of Cameroon.Cedrigue Boris Djiongo Kenfack, Olivier Monga, Serge Moto Mpong & René Ndoundam - 2018 - Acta Biotheoretica 66 (1):17-60.
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  50. added 2018-10-11
    Autonomous Mathematical Models: Constructing Theories of Metabolic Control.Josephine Donaghy - 2013 - History and Philosophy of the Life Sciences 35 (4):533-552.
    This paper considers how the relationship between mathematical models and theories in biology may change over time, on the basis of a historical analysis of the development of a mathematical model of metabolism, metabolic control analysis, and its relationship to theories of metabolic control. I argue that one can distinguish two ways of characterising the relationship between models and theories, depending on the stage of model and/or theory development that one is considering: partial independence and autonomy. Partial independence describes a (...)
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