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  1. added 2020-04-29
    Information-Matter Bipolarity of the Human Organism and Its Fundamental Circuits: From Philosophy to Physics/Neurosciences-Based Modeling.Florin Gaiseanu - 2020 - Philosophy Study 10 (2):107-118.
    Starting from a philosophical perspective, which states that the living structures are actually a combination between matter and information, this article presents the results on an analysis of the bipolar information-matter structure of the human organism, distinguishing three fundamental circuits for its survival, which demonstrates and supports this statement, as a base for further development of the informational model of consciousness to a general informational model of the human organism. For this, it was examined the Informational System of the Human (...)
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  2. added 2020-03-10
    Four Ways From Universal to Particular: How Chomsky's Language-Acquisition Faculty is Not Selectionist.David Ellerman - 2016 - Journal of Applied Non-Classical Logics 3 (26):193-207.
    Following the development of the selectionist theory of the immune system, there was an attempt to characterize many biological mechanisms as being "selectionist" as juxtaposed to "instructionist." But this broad definition would group Darwinian evolution, the immune system, embryonic development, and Chomsky's language-acquisition mechanism as all being "selectionist." Yet Chomsky's mechanism (and embryonic development) are significantly different from the selectionist mechanisms of biological evolution or the immune system. Surprisingly, there is a very abstract way using two dual mathematical logics to (...)
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  3. added 2020-02-19
    Glycemia Regulation: From Feedback Loops to Organizational Closure.Leonardo Bich, Matteo Mossio & Ana M. Soto - 2020 - Frontiers in Physiology 11.
    Endocrinologists apply the idea of feedback loops to explain how hormones regulate certain bodily functions such as glucose metabolism. In particular, feedback loops focus on the maintenance of the plasma concentrations of glucose within a narrow range. Here, we put forward a different, organicist perspective on the endocrine regulation of glycaemia, by relying on the pivotal concept of closure of constraints. From this perspective, biological systems are understood as organized ones, which means that they are constituted of a set of (...)
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  4. added 2020-02-11
    Philosophy of Experimental Biology.Jacob Stegenga - 2009 - Erkenntnis 71 (3):431-436.
    Philosophers have committed sins while studying science, it is said – philosophy of science focused on physics to the detriment of biology, reconstructed idealizations of scientific episodes rather than attending to historical details, and focused on theories and concepts to the detriment of experiments. Recent generations of philosophers of science have tried to atone for these sins, and by the 1980s the exculpation was in full swing. Marcel Weber’s Philosophy of Experimental Biology is a zenith mea culpa for philosophy of (...)
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  5. added 2020-01-23
    Cancer Modeling: The Advantages and Limitations of Multiple Perspectives.A. Plutynski - 2019 - In Michela Massimi & Casey McCoy (eds.), Understanding Perspectivism: Scientific Challenges and Methodological Prospects. New York: Routledge.
    Cancer is a paradigmatic case of a complex causal process; causes of cancer operate at a variety of temporal and spatial scales, and the respects in which these causes act and interact are diverse. There are, for instance, temporal order effects, organizational effects, structural effects, and dynamic relationships between causes operating at different temporal and spatial scales. Because of this complexity, models of cancer initiation and progression often involve deliberate choices to focus on one time scale, one causal pathway, or (...)
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  6. added 2020-01-13
    Unifying the Essential Concepts of Biological Networks.Daniel Kostic, Claus Hilgetag & Marc Tittgemeyer (eds.) - forthcoming - Royal Society.
  7. added 2020-01-10
    Some Concerns Regarding Explanatory Pluralism: The Explanatory Role of Optimality Models.Gabriel Târziu - 2019 - Filozofia Nauki 28 (4):95-113.
    Optimality models are widely used in different parts of biology. Two important questions that have been asked about such models are: are they explanatory and, if so, what type of explanations do they offer? My concern in this paper is with the approach of Rice (2012, 2015) and Irvine (2015), who claim that these models provide non-causal explanations. I argue that there are serious problems with this approach and with the accounts of explanation it is intended to justify. The idea (...)
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  8. added 2019-12-31
    Life/Force: Novelty and New Materialism in Jane Bennett's Vibrant Matter.Jonathan Basile - 2019 - Substance 48 (2):3-22.
    Among those speaking in the name of materialism, whether speculative, dialectical, or "new," it is commonplace to dismiss with a single gesture a vast field of theoretical and philosophical endeavor, indicated as the last 50 or 250 years of theory and philosophy. Self-styled "speculative" writers who would surpass all philosophy since Kant, and various New Materialists who sequester decades of thought under the heading of "constructivism," manufacture the avant-garde status of their own work by claiming to delineate a simple break (...)
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  9. added 2019-10-22
    Analytic Philosophy for Biomedical Research: The Imperative of Applying Yesterday's Timeless Messages to Today's Impasses.Sepehr Ehsani - forthcoming - In P. Glauner & P. Plugmann (eds.), Innovative Technologies for Market Leadership - Investing in the Future. Springer.
    The mantra that "the best way to predict the future is to invent it" (attributed to the computer scientist Alan Kay) exemplifies some of the expectations from the technical and innovative sides of biomedical research at present. However, for technical advancements to make real impacts both on patient health and genuine scientific understanding, quite a number of lingering challenges facing the entire spectrum from protein biology all the way to randomized controlled trials should start to be overcome. The proposal in (...)
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  10. added 2019-09-18
    Biosemiosis and Causation: Defending Biosemiotics Through Rosen's Theoretical Biology, or, Integrating Biosemiotics and Anticipatory Systems Theory.Arran Gare - 2019 - Cosmos and History 19 (1):31-90.
    The fracture in the emerging discipline of biosemiotics when the code biologist Marcello Barbieri claimed that Peircian biosemiotics is not genuine science raises anew the question: What is science? When it comes to radically new approaches in science, there is no simple answer to this question, because if successful, these new approaches change what is understood to be science. This is what Galileo, Darwin and Einstein did to science, and with quantum theory, opposing interpretations are not merely about what theory (...)
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  11. added 2019-08-20
    Genetic Relatedness and Its Causal Role in the Evolution of Insect Societies.Tuomas K. Pernu - 2019 - Journal of Biosciences 44:107.
    The role of genetic relatedness in social evolution has recently come under critical attention. These arguments are here critically analyzed, both theoretically and empirically. It is argued that when the conceptual structure of the theory of natural selection is carefully taken into account, genetic relatedness can be seen to play an indispensable role in the evolution of both facultative and advanced eusociality. Although reviewing the empirical evidence concerning the evolution of eusociality reveals that relatedness does not play a role in (...)
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  12. added 2019-07-05
    Possibility Spaces and the Notion of Novelty: From Music to Biology.Maël Montévil - 2019 - Synthese 196 (11):4555-4581.
    We provide a new perspective on the relation between the space of description of an object and the appearance of novelties. One of the aims of this perspective is to facilitate the interaction between mathematics and historical sciences. The definition of novelties is paradoxical: if one can define in advance the possibles, then they are not genuinely new. By analyzing the situation in set theory, we show that defining generic (i.e., shared) and specific (i.e., individual) properties of elements of a (...)
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  13. added 2019-07-05
    Perspectives On Organisms: Biological Time, Symmetries And Singularities.Maël Montévil & Giuseppe Longo - 2014 - Springer.
    This authored monograph introduces a genuinely theoretical approach to biology. Starting point is the investigation of empirical biological scaling including their variability, which is found in the literature, e.g. allometric relationships, fractals, etc. The book then analyzes two different aspects of biological time: first, a supplementary temporal dimension to accommodate proper biological rhythms; secondly, the concepts of protension and retention as a means of local organization of time in living organisms. Moreover, the book investigates the role of symmetry in biology, (...)
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  14. added 2019-06-06
    Coupling Simulation and Experiment: The Bimodal Strategy in Integrative Systems Biology.Miles MacLeod & Nancy J. Nersessian - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4a):572-584.
    The importation of computational methods into biology is generating novel methodological strategies for managing complexity which philosophers are only just starting to explore and elaborate. This paper aims to enrich our understanding of methodology in integrative systems biology, which is developing novel epistemic and cognitive strategies for managing complex problem-solving tasks. We illustrate this through developing a case study of a bimodal researcher from our ethnographic investigation of two systems biology research labs. The researcher constructed models of metabolic and cell-signaling (...)
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  15. added 2019-06-06
    When One Model is Not Enough: Combining Epistemic Tools in Systems Biology.Sara Green - 2013 - Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):170-180.
    In recent years, the philosophical focus of the modeling literature has shifted from descriptions of general properties of models to an interest in different model functions. It has been argued that the diversity of models and their correspondingly different epistemic goals are important for developing intelligible scientific theories. However, more knowledge is needed on how a combination of different epistemic means can generate and stabilize new entities in science. This paper will draw on Rheinberger’s practice-oriented account of knowledge production. The (...)
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  16. added 2019-06-06
    The Handicap Principle and the Argument of Subversion From Within.Christian Baron - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (3):347-355.
    This paper examines the very disparate positions that various actors have taken towards the argument of subversion from within in a set of related debates on group selection, altruism and the handicap principle. Using this set of debates as a case study, this paper argues that different applications of epistemic values were one of the factors behind the disagreements between John Maynard Smith and Amotz Zahavi over a number of important evolutionary issues. The paper also argues that these different applications (...)
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  17. added 2019-06-05
    On the Incompatibility of Dynamical Biological Mechanisms and Causal Graphs.Marcel Weber - 2016 - Philosophy of Science 83 (5):959-971.
    I examine to what extent accounts of mechanisms based on formal interventionist theories of causality can adequately represent biological mechanisms with complex dynamics. Using a differential equation model for a circadian clock mechanism as an example, I first show that there exists an iterative solution that can be interpreted as a structural causal model. Thus, in principle it is possible to integrate causal difference-making information with dynamical information. However, the differential equation model itself lacks the right modularity properties for a (...)
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  18. added 2019-06-05
    Practice Oriented Controversies and Borrowed Epistemic Support in Current Evolutionary Biology. The Case of Phylogeography.Alfonso Arroyo-Santos, Mark E. Olson & Francisco Vergara-Silva - 2015 - Perspectives on Science 23 (3):310-334.
    Although there is increasing recognition that theory and practice in science are often inseparably intertwined, discussions of scientific controversies often continue to focus on theory, and not practice or methodologies. As a contribution to constructing a framework towards understanding controversies linked to scientific practices, we introduce the notion of borrowed epistemic credibility, to describe the situation in which scientists exploit fallacious similarities between accepted tenets in other fields to garner support for a given position in their own field. Our proposal (...)
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  19. added 2019-06-05
    Causal Explanation Beyond the Gene: Manipulation and Causality in Epigenetics.Jan Baedke - 2012 - Theoria : An International Journal for Theory, History and Fundations of Science 27 (2):153-174.
    _This paper deals with the interrelationship between causal explanation and methodology in a relatively young discipline in biology: epigenetics. Based on cases from molecular and ecological epigenetics, I show that James Woodward’s interventionist account of causation captures essential features about how epigeneticists using highly diverse methods, i.e. laboratory experiments and purely observational studies, think about causal explanation. I argue that interventionism thus qualifies as a useful unifying explanatory approach when it comes to cross-methodological research efforts: It can act as a (...)
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  20. added 2019-06-05
    Was There Information in My Data? Really?: Model Based Inference in the Life Sciences: A Primer on Evidence David R. Anderson New York: Springer, 2008.Fred L. Bookstein - 2009 - Biological Theory 4 (3):302-308.
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  21. added 2019-06-05
    Game Theory as Mathematics for Biology: Evolutionary Dynamics and Extensive Form Games Ross Cressman Cambridge, MA: MIT Press, 2003 (330 Pp; $48.00 Hbk; ISBN 0262033054); Moral Sentiments and Material Interests Herbert Gintis , Samuel Bowles , Robert Boyd and Ernst Fehr , Eds Cambridge, MA: MIT Press, 2005 (416 Pp; $50.00 Hbk; ISBN 0262072521).Don Ross - 2007 - Biological Theory 2 (1):104-107.
  22. added 2019-06-05
    A Real Foundation for Virtual Reconstruction: Virtual Reconstruction: A Primer in Computer-Assisted Paleontology and Biomedicine.Dennis E. Slice - 2007 - Biological Theory 2 (4):432-434.
  23. added 2019-05-30
    Formal Methods for Hopfield-Like Networks.Hedi Ben Amor, Fabien Corblin, Eric Fanchon, Adrien Elena, Laurent Trilling, Jacques Demongeot & Nicolas Glade - 2013 - Acta Biotheoretica 61 (1):21-39.
    Building a meaningful model of biological regulatory network is usually done by specifying the components and their interactions, by guessing the values of parameters, by comparing the predicted behaviors to the observed ones, and by modifying in a trial-error process both architecture and parameters in order to reach an optimal fitness. We propose here a different approach to construct and analyze biological models avoiding the trial-error part, where structure and dynamics are represented as formal constraints. We apply the method to (...)
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  24. added 2019-05-30
    Reduced Models for Unidirectional Block Conduction and Their Geometrical Setting.L. El Alaoui, J. -P. Francoise & M. Landau - 2012 - Acta Biotheoretica 60 (1-2):131-137.
    This article revisits a reduced model of cardiac electro-physiology which was proposed to understand the genesis of unidirectional block pathology and of ectopic foci. We underline some specificities of the model from the viewpoint of dynamical systems and bifurcation theory. We point out that essentially the same properties are shared by a simpler system more accessible to analysis. With this simpler system, it becomes possible to give a new presentation of the phenomenon in a phase plane with time moving slow (...)
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  25. added 2019-04-07
    Control by Viability in a Chemotherapy Cancer Model.M. Serhani, H. Essaadi, K. Kassara & A. Boutoulout - 2019 - Acta Biotheoretica 67 (3):177-200.
    The aim of this study is to provide a feedback control, called the Chemotherapy Protocol Law, with the purpose to keep the density of tumor cells that are treated by chemotherapy below a “tolerance level” L_c, while retaining the density of normal cells above a “healthy level” N_c. The mathematical model is a controlled dynamical system involving three nonlinear differential equations, based on a Gompertzian law of cell growth. By evoking viability and set-valued theories, we derive sufficient conditions for the (...)
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  26. added 2019-03-17
    Mathematical Modeling of Substrates Fluxes and Tumor Growth in the Brain.Angélique Perrillat-Mercerot, Nicolas Bourmeyster, Carole Guillevin, Alain Miranville & Rémy Guillevin - 2019 - Acta Biotheoretica 67 (2):149-175.
    The aim of this article is to show how a tumor can modify energy substrates fluxes in the brain to support its own growth. To address this question we use a modeling approach to explain brain nutrient kinetics. In particular we set up a system of 17 equations for oxygen, lactate, glucose concentrations and cells number in the brain. We prove the existence and uniqueness of nonnegative solutions and give bounds on the solutions. We also provide numerical simulations.
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  27. added 2019-03-11
    Preparations, Models, and Simulations.Hans-Jörg Rheinberger - 2015 - History and Philosophy of the Life Sciences 36 (3):321-334.
    This paper proposes an outline for a typology of the different forms that scientific objects can take in the life sciences. The first section discusses preparations (or specimens)—a form of scientific object that accompanied the development of modern biology in different guises from the seventeenth century to the present: as anatomical–morphological specimens, as microscopic cuts, and as biochemical preparations. In the second section, the characteristics of models in biology are discussed. They became prominent from the end of the nineteenth century (...)
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  28. added 2019-03-11
    Mendel’s Use of Mathematical Modelling: Ratios, Predictions and the Appeal to Tradition.Amir Teicher - 2014 - History and Philosophy of the Life Sciences 36 (2):187-208.
    The seventh section of Gregor Mendel’s famous 1866 paper contained a peculiar mathematical model, which predicted the expected ratios between the number of constant and hybrid types, assuming self-pollination continued throughout further generations. This model was significant for Mendel’s argumentation and was perceived as inseparable from his entire theory at the time. A close examination of this model reveals that it has several perplexing aspects which have not yet been systematically scrutinized. The paper analyzes those aspects, dispels some common misconceptions (...)
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  29. added 2019-03-04
    Individual Based Model for Grouper Populations.Slimane Ben Miled, Amira Kebir & Moulay Lhassan Hbid - 2010 - Acta Biotheoretica 58 (2-3):247-264.
    Dusky groupers (Epinephelus marginatus) are characterized by a complex sex allocation strategies and overexploitation of bigger individuals. We developed an individual based model to investigate the long-term effects of density dependence on grouper population dynamics and to analyze the variabilities of extinction probabilities as a result of interacting mortalities at different life stages. We conduct several simulations with different forms of sex allocation functions and different combinations of mortality rates. The model was parametrized using data on dusky grouper populations from (...)
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  30. added 2019-02-25
    Constructing Reality with Models.Tee Sim-Hui - 2019 - Synthese 196 (11):4605-4622.
    Scientific models are used to predict and understand the target phenomena in the reality. The kind of epistemic relationship between the model and the reality is always regarded by most of the philosophers as a representational one. I argue that, complementary to this representational role, some of the scientific models have a constructive role to play in altering and reconstructing the reality in a physical way. I hold that the idealized model assumptions and elements bestow the constructive force of a (...)
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  31. added 2019-02-24
    Holobionts as Units of Selection and a Model of Their Population Dynamics and Evolution.Joan Roughgarden, Scott F. Gilbert, Eugene Rosenberg, Ilana Zilber-Rosenberg & Elisabeth A. Lloyd - 2018 - Biological Theory 13 (1):44-65.
    Holobionts, consisting of a host and diverse microbial symbionts, function as distinct biological entities anatomically, metabolically, immunologically, and developmentally. Symbionts can be transmitted from parent to offspring by a variety of vertical and horizontal methods. Holobionts can be considered levels of selection in evolution because they are well-defined interactors, replicators/reproducers, and manifestors of adaptation. An initial mathematical model is presented to help understand how holobionts evolve. The model offered combines the processes of horizontal symbiont transfer, within-host symbiont proliferation, vertical symbiont (...)
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  32. added 2019-02-24
    A Model of Isotope Separation in Plants.A. Bokunyaeva & A. Melkikh - 2017 - Acta Biotheoretica 65 (4):271-284.
    A model representing isotope separation during water evaporation in plants was constructed. The model accounts for substance diffusion, convective transfer and evaporation from the surface of the leaves. The dependence of the system’s separation and enrichment coefficients on various parameters was determined. A comparison was made between the enrichment coefficients calculated from experimental data from different plants and those based on the model. Qualitative agreement between the experimental and theoretical values was obtained for the case of $$\frac{uh}{D} {\gg} 1$$ uh (...)
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  33. added 2019-02-18
    The Power of Mathematical Modeling in Developmental Biology: Biological Physics of the Developing Embryo Gabor Forgacs and Stuart A. Newman Cambridge: Cambridge University Press, 2005 (337 Pp; $ 64 Hbk; ISBN 0-521-78337-2).Diego Rasskin-Gutman - 2007 - Biological Theory 2 (1):108-111.
  34. added 2019-02-08
    Artificial and Natural Genetic Information Processing.Guenther Witzany - 2017 - In Mark Burgin & Wolfgang Hofkirchner (eds.), Information Studies and the Quest for Transdisciplinarity. Singapore: World Scientific. pp. 523-547.
    Conventional methods of genetic engineering and more recent genome editing techniques focus on identifying genetic target sequences for manipulation. This is a result of historical concept of the gene which was also the main assumption of the ENCODE project designed to identify all functional elements in the human genome sequence. However, the theoretical core concept changed dramatically. The old concept of genetic sequences which can be assembled and manipulated like molecular bricks has problems in explaining the natural genome-editing competences of (...)
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  35. added 2019-02-03
    Graphical Representation and Similarity Analysis of DNA Sequences Based on Trigonometric Functions.Guo-Sen Xie, Xiao-Bo Jin, Chunlei Yang, Jiexin Pu & Zhongxi Mo - 2018 - Acta Biotheoretica 66 (2):113-133.
    In this paper, we propose two four-base related 2D curves of DNA primary sequences and their corresponding single-base related 2D curves. The constructions of these graphical curves are based on the assignments of individual base to four different sinusoidal functions; then by connecting all these points on these four sinusoidal functions, we can get the F-B curves; similarly, by connecting the points on each of the four sinusoidal functions, we get the single-base related 2D curves. The proposed 2D curves are (...)
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  36. added 2019-02-03
    Asymptotic Behavior of a Chemostat Model with Constant Recycle Sludge Concentration.Karim Yadi & Mohamed Hamra - 2017 - Acta Biotheoretica 65 (3):233-252.
    In this work, we study a several species aerobic chemostat model with constant recycle sludge concentration in continuous culture. We reduce the number of parameters by considering a dimensionless model. First, the existence of a global positive uniform attractor for the model with different removal rates is proved using the theory of dissipative dynamical systems. Hence, we investigate the asymptotic behavior of the model under small perturbations using methods of singular perturbation theory and we prove that, in the case of (...)
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  37. added 2019-02-03
    Basin of Attraction of Solutions with Pattern Formation in Slow–Fast Reaction–Diffusion Systems.M. Aziz-Alaoui & B. Ambrosio - 2016 - Acta Biotheoretica 64 (4):311-325.
    This article is devoted to the characterization of the basin of attraction of pattern solutions for some slow–fast reaction–diffusion systems with a symmetric property and an underlying oscillatory reaction part. We characterize some subsets of initial conditions that prevent the dynamical system to evolve asymptotically toward solutions which are homogeneous in space. We also perform numerical simulations that illustrate theoretical results and give rise to symmetric and non-symmetric pattern solutions. We obtain these last solutions by choosing particular random initial conditions.
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  38. added 2019-01-28
    The Role of Hyalomma Truncatum on the Dynamics of Rift Valley Fever: Insights From a Mathematical Epidemic Model.Henri E. Z. Tonnang, Shirley Abelman & Sansao A. Pedro - 2017 - Acta Biotheoretica 65 (1):1-36.
    To date, our knowledge of Rift Valley fever disease spread and maintenance is still limited, as flooding, humid weather and presence of biting insects such as mosquitoes, have not completely explained RVF outbreaks. We propose a model that includes livestock, mosquitoes and ticks compartments structured according to their questing and feeding behaviour in order to study the possible role of ticks on the dynamics of RVF. To quantify disease transmission at the initial stage of the epidemic, we derive an explicit (...)
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  39. added 2019-01-28
    On the Role of Imitation on Adolescence Methamphetamine Abuse Dynamics.A. Stewart, G. Muchatibaya, F. Nyabadza & J. Mushanyu - 2017 - Acta Biotheoretica 65 (1):37-61.
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  40. added 2019-01-28
    Hopf Bifurcations in Directed Acyclic Networks of Linearly Coupled Hindmarsh–Rose Systems.N. Verdière, V. Lanza & N. Corson - 2016 - Acta Biotheoretica 64 (4):375-402.
    This paper addresses the existence of Hopf bifurcations in a directed acyclic network of neurons, each of them being modeled by a Hindmarsh–Rose neuronal model. The bifurcation parameter is the small parameter corresponding to the ratio of time scales between the fast and the slow dynamics. We first prove that, under certain hypotheses, the single uncoupled neuron can undergo a Hopf bifurcation. Hopf bifurcation occurrences in a directed acyclic network of HR neurons are then discussed. Numerical simulations are carried out (...)
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  41. added 2019-01-28
    Interactions Between the Cross-Shore Structure of Small Pelagic Fish Population, Offshore Industrial Fisheries and Near Shore Artisanal Fisheries: A Mathematical Approach.Alain Miranville, Rémy Guillevin, Jean-Pierre Françoise & Hermine Biermé - 2016 - Acta Biotheoretica 64 (4):479-493.
    This work presents a mathematical model describing the interactions between the cross-shore structure of small pelagic fish population an their exploitation by coastal and offshore fisheries. The complete model is a system of seven ODE’s governing three stocks of small pelagic fish population moving and growing between three zones. Two types of fishing fleets are inter-acting with the fish population, industrial boats, constrained to offshore area, and artisanal boats, operating from the shore. Two time scales were considered and we use (...)
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  42. added 2019-01-28
    Mathematical Model of the Dynamics of Fish, Waterbirds and Tourists in the Djoudj National Park, Senegal.Abdou Sène & Oumar Diop - 2016 - Acta Biotheoretica 64 (4):447-468.
    In the present paper, we propose and analyze a harvested predator–prey model that incorporates the dynamics of tourists in the Djoudj National Park of Birds, Senegal. The model describes the impact of migration of waterbirds and seasonal fishing on the global coexistence of species in the site of the Djoudj. By the Mahwin continuation theorem of coincidence degree theory, we investigate the existence of a positive periodic solution. The global asymptotic stability is discussed by constructing a suitable Lyapunov functional. Some (...)
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  43. added 2019-01-28
    A Mathematical Model for Alternation of Polygamy and Parthenogenesis: Stability Versus Efficiency and Analogy with Parasitism.Jean-Pierre Françoise, Philippe Lherminier & Evariste Sanchez-Palencia - 2016 - Acta Biotheoretica 64 (4):537-552.
    The present work is a contribution to the understanding of the sempiternal problem of the “burden of factor two” implied by sexual reproduction versus asexual one, as males are energy consumers not contributing to the production of offspring. We construct a deterministic mathematical model in population dynamics where a species enjoys both sexual and parthenogenetic capabilities of reproduction and lives on a limited resource. We then show how polygamy implies instability of a parthenogenetic population with a small number of sexually (...)
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  44. added 2019-01-28
    Can Fishing Pressure Invert the Outcome of Interspecific Competition? The Case of the Thiof and of the Octopus Along the Senegalese Coast.Didier Jouffre, Sidy Ly, Pierre Auger, Doanh Nguyen-Ngoc & Thuy Nguyen-Phuong - 2016 - Acta Biotheoretica 64 (4):519-536.
    We present a mathematical model of two competing marine species that are harvested. We consider three models according to different levels of complexity, without and with species refuge and density-independent and density-dependent species movement between fishing area and refuge. We particularly study the effects of the fishing pressure on the outcome of the competition. We focus on conditions that allow an inferior competitor to invade as a result of fishing pressure. The model is discussed in relationship to the case of (...)
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  45. added 2019-01-28
    Influence of Antithrombin on the Regimes of Blood Coagulation: Insights From the Mathematical Model.Alain Miranville, Rémy Guillevin, Jean-Pierre Françoise & Hermine Biermé - 2016 - Acta Biotheoretica 64 (4):327-342.
    Blood coagulation is regulated through a complex network of biochemical reactions of blood factors. The main acting enzyme is thrombin whose propagation in blood plasma leads to fibrin clot formation. Spontaneous clot formation is normally controlled through the action of different plasma inhibitors, in particular, through the thrombin binding by antithrombin. In the current study we develop a mathematical model of clot formation both in quiescent plasma and in blood flow and determine the analytical conditions on the antithrombin concentration corresponding (...)
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  46. added 2019-01-28
    Recursive Model Identification for the Evaluation of Baroreflex Sensitivity.Alfredo Hernández, Patrick Pladys, Nathalie Samson, Jean-Paul Praud, Alain Beuchée & Virginie Le Rolle - 2016 - Acta Biotheoretica 64 (4):469-478.
    A method for the recursive identification of physiological models of the cardiovascular baroreflex is proposed and applied to the time-varying analysis of vagal and sympathetic activities. The proposed method was evaluated with data from five newborn lambs, which were acquired during injection of vasodilator and vasoconstrictors and the results show a close match between experimental and simulated signals. The model-based estimation of vagal and sympathetic contributions were consistent with physiological knowledge and the obtained estimators of vagal and sympathetic activities were (...)
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  47. added 2019-01-21
    Culture and the Trajectories of Developmental Pathology: Insights From Control and Information Theories.Rodrick Wallace - 2018 - Acta Biotheoretica 66 (2):79-112.
    Cognition in living entities -- and their social groupings or institutional artifacts -- is necessarily as complicated as their embedding environments, which, for humans, includes a particularly rich cultural milieu. The asymptotic limit theorems of information and control theories permit construction of a new class of empirical 'regression-like' statistical models for cognitive developmental processes, their dynamics, and modes of dysfunction. Such models may, as have their simpler analogs, prove useful in the study and remediation of cognitive failure at and across (...)
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  48. added 2019-01-14
    How to Use Fitness Landscape Models for the Analysis of Collective Decision-Making: A Case of Theory-Transfer and its Limitations.Peter Marks, Lasse Gerrits & Johannes Marx - 2019 - Biology and Philosophy 34 (1):7.
    There is considerable correspondence between theories and models used in biology and the social sciences. One type of model that is in use in both biology and the social sciences is the fitness landscape model. The properties of the fitness landscape model have been applied rather freely in the social domain. This is partly due to the versatility of the model, but it is also due to the difficulties of transferring a model to another domain. We will demonstrate that in (...)
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  49. added 2019-01-14
    Importance of Initial Concentration of Factor VIII in a Mechanistic Model of In Vitro Coagulation.M. Susree & M. Anand - 2018 - Acta Biotheoretica 66 (3):201-212.
    This computational study generates a hypothesis for the coagulation protein whose initial concentration greatly influences the course of coagulation. Many clinical malignancies of blood coagulation arise due to abnormal initial concentrations of coagulation factors. Sensitivity analysis of mechanistic models of blood coagulation is a convenient method to assess the effect of such abnormalities. Accordingly, the study presents sensitivity analysis, with respect to initial concentrations, of a recently developed mechanistic model of blood coagulation. Both the model and parameters to which model (...)
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  50. added 2019-01-14
    A Credible-World Account of Biological Models.Sim-Hui Tee - 2018 - Axiomathes 28 (3):309-324.
    In a broad brush, biological models are often constructed in two general types: as a concrete model; as an abstract model. A concrete model is a material model such as model organisms, while an abstract model is a mathematical or computational model consists of equations or algorithms. Though there are types of biological models that cannot be strictly categorized as either concrete or abstract, they are falling somewhere in between this spectrum. In view of the fact that biological phenomena are (...)
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