The number of cellular events identified as being directly or indirectly modulated by phosphoinositides dramatically increased in the recent years. Part of the complexity results from the fact that the seven phosphoinositides play second messenger functions in many different areas of growth factors and insulin signaling, cytoskeletal organization, membrane dynamics, trafficking, or nuclear signaling. PtdIns(3,4)P2 is commonly reported as a product of the SH2 domain‐containing inositol 5‐phosphatases 1/2 (SHIP1 and SHIP2) that dephosphorylate PtdIns(3,4,5)P3 at the 5‐position. Here we discuss recent (...) interest in PtdIns(3,4)P2 signaling highlighting its involvement in key cellular mechanisms such as cell adhesion, migration, and cytoskeletal regulation. We question and discuss the involvement of SHIP2 either as a PI 5‐phosphatase or as a scaffold protein in insulin signaling, cytoskeletal dynamics, and endocytosis of growth factor receptors. (shrink)

This paper explores the differences in high-accuracy and low-accuracy learners’ beliefs about corrective feedback when learning Chinese as a second language. In this study, we collected data through a questionnaire survey and an oral test with 76 CSL learners in a Chinese university. The analysis revealed that both high- and low-accuracy CSL learners shared the same beliefs in whether and how the learner errors should be corrected but differed in their beliefs about when is the best time to correct, which (...) error should be corrected, and who the corrector should be. Specifically, the discrepancy between high- and low-accuracy groups’ beliefs about corrective feedback was found to be related to the participants’ oral accuracy. Our results confirm that learners’ CF beliefs can modulate their language accuracy. The corrective feedback beliefs held by high-accuracy groups have implications for improving low-accuracy groups’ oral accuracy. Through comparison with findings on corrective feedback beliefs of English as a foreign/second language learners, this study suggested that language pedagogies developed from the research of EFL/ESL learners’ CF beliefs should be able to shed light on this area and have significance for CSL learners. Implications for correcting learner errors in teaching CSL are also provided in the paper. (shrink)

Humor can be used as a tool for a wide range of tasks, including fighting for social justice. How to most effectively use it, however, is a matter of contention. Jokes that alienate members of an out-group can be called “Otherizing,” and can cause harm by virtue of the alienation. Woke comics, like Hari Kondabolu, intentionally avoid Otherizing in general, but may engage in a version of it that seeks to defang stereotypical treatments of out-groups by replacing the alienating content (...) with something benign. We term this use of Otherizing, “mOtherizing.” Pride comics, like Russell Peters, take a different approach and try to usurp the power of Otherizing by over-engaging in it. The intention is to use the jokes to cobble together a coalition of out-groups that turns itself into an in-group. We term this use of Otherizing, “brOtherizing.”. (shrink)

The purpose of this research is to examine the influence of servant leadership on teachers of moral education degree programs in Pakistan. By utilizing social learning, we propose that servant leadership and perceived coworker support can reduce the knowledge hiding by enhancing the sense of organization-based psychological ownership. The findings of time-lagged and multi-source data indicate that servant leadership has a negative relationship with knowledge hiding. Our results also indicate that psychological ownership mediates the effects of servant leadership on knowledge (...) hiding. Moreover, a higher level of perceived coworker support enhances the sense of psychological ownership which helps to reduce knowledge hiding. This research extends strong support for the proposition that servant leaders who adopt an employee-centered management approach, stressing personal integrity and care for employees significantly affect employee attitudes and behaviors. Moreover, this study suggests that managers should demonstrate care toward their subordinates which helps them to reduce negative behaviors. (shrink)

The biology major has developed rapidly in recent years. Biology is a science that penetrates every aspect of human life and is one of the core majors in most agricultural colleges and universities. However, many teachers lack practical experience in the subject. To overcome this problem, in recent years, we have been trying to introduce new reforms into our teaching. This article provides some insight into the way that biology majors have been reformed, which will help educators in agricultural colleges (...) and universities. At present, teachers implement the “Industrial Innovation and Entrepreneurship Talent Cultivation” model, but it is not clear whether this helps biology majors to master the course and improve their practical skills. In this study, the IIETC model is outlined, and the academic achievement and satisfaction of students taught under the IIETC model are assessed. A T-test is used to examine potential differences between IIETC and traditional teaching models. In-depth interviews and questionnaires were given to two groups of students who followed different teaching models as part of an exploratory study. The aim was to explore how effective IIETC is at helping biology majors master the course and improve students’ wellbeing. Our results show that compared with traditional teaching methods, the IIETC model has a significant positive impact on the academic performance and happiness of biology students. Students trained under the IIETC model were more active and scored more highly in their final exams. They were more likely to feel that they had achieved success and happiness through the course. The outcomes of this research reveal a novel teaching reform that improved students’ enthusiasm for innovation and entrepreneurship during the ongoing COVID-19 pandemic. The effects are very encouraging and deserve further exploration and expansion in future work. (shrink)

The enterprise network is of great significance in explaining the risk-taking of individual firm. However, some unobservable networks hidden in different firms have long been neglected. Using the text data of the annual reports of China’s listed firms from 2007 to 2018, this paper adopts a textual analysis method to capture the managers’ perceptions of pressure, and build a special kind of hidden inter-firm networks, that is, the perceived competition networks of managers. In addition, this paper discusses the impact of (...) network characteristics on corporate risk-taking behavior. Empirically, there is a positive association between competition strength and corporate risk-taking, as well as the density of perceived competition network. Furthermore, this paper explores the risk-taking behaviors of peer firms in focal firm’s perceived competition network, and finds that the improvement of peer firms’ risk-taking significantly increases the risk bearing level of focal firm, that is, the positive spillover effect of risk-taking behavior among firms in perceived competition networks. Moreover, managers’ personal traits significantly moderate the impact of network characteristics on corporate risk-taking, which is mainly reflected in younger and male managers. Our findings can enrich the literature on social interactions and corporate behaviors, and help firms to improve their understanding of perceptible peer firms. (shrink)

With the emergence of numerous link prediction methods, how to accurately evaluate them and select the appropriate one has become a key problem that cannot be ignored. Since AUC was first used for link prediction evaluation in 2008, it is arguably the most preferred metric because it well balances the role of wins and the role of draws. However, in many cases, AUC does not show enough discrimination when evaluating link prediction methods, especially those based on local similarity. Hence, we (...) propose a new metric, called W-index, which considers only the effect of wins rather than draws. Our extensive experiments on various networks show that the W-index makes the accuracy scores of link prediction methods more distinguishable, and it can not only widen the local gap of these methods but also enlarge their global distance. We further show the reliability of the W-index by ranking change analysis and correlation analysis. In particular, some community-based approaches, which have been deemed effective, do not show any advantages after our reevaluation. Our results suggest that the W-index is a promising metric for link prediction evaluation, capable of offering convincing discrimination. (shrink)

The biotech revolution profoundly changes and reconstructs the Foucaultian concept of biopolitics from different dimensions. It declares the coming of the Age of Biocapitalism, which opens a new pattern of modern power allocation of life governance and shows people two prospects simultaneously: utopian hopes and dystopian desperation. Biocapitalism has not only produced ethical degeneration and cultural shock, but more importantly, has opened new areas for political hegemony and economic aggression through the reconstruction of biopolitics, and the enhancement of capital’s comprehensive (...) dominance on nature and the human society. Therefore, it has become an area of serious, scholarly research in the biotech era to explore the implications of contemporary biopolitics, to take precautions against, and reduce the real risks of technocapitalism. This paper investigates the new biopolitics supported by the manipulation of modern biotechnology, especially genetic engineering, and unveils the possible hazards and deep contradictions inherent in this capital-controlled science, within the context of biocapitalism. It also seeks ways to prevent technological alienation and to reconstruct political rationality. It argues that entrepreneurs, scientists, companies and universities of developed countries must realize the limits of capital expansion and the self―regulatory capability of the market, and, then, assume ethical responsibilities as biocapital holders. (shrink)

With the global society aging, it is necessary to investigate suitable font size based on reading time/speed, readability and legibility for older adults. This study used a systematic review of previous and existing relevant research on font size for older adults and research on the psychophysics of reading and analyzed the outcomes based on reading time/speed, readability, legibility and the usability evaluation methods employed. Studies were selected from databases GOOGLE SCHOLAR, WEB OF SCIENCE, PUBMED, and SCIENCE DIRECT. An inclusion criterion (...) was used to remove duplicates and avoid inconsistencies. Results suggest that older adults preferred larger font sizes. However, there exists a critical size at which readability declines. Inconsistencies in evaluation methods and experimental procedures were observed in the selected articles. This study suggested a reusable catalog of usability evaluation methods, eye tracking for user testing and a questionnaire for inquiry as suitable usability evaluation methods, a uniform metrics to measure font size in arcminutes and parameters to consider when investigating font size for older adults to ensure consistency in future studies. (shrink)

At present, integrated energy systems have received extensive attention, but there is no basic framework for stability analysis of coupled systems. The injection of a large amount of renewable energy also has a great impact on the stability of the system. This paper focuses on how to analyze the static stability of the coupling system with uncertainty, which mainly considers the uncertainty of wind power generation and photovoltaic power generation and also considers the influence of P2G technology on the whole (...) system. Firstly, this paper analyzes the principles of wind power generation and photovoltaic power generation and constructs the probability model of renewable energy power generation power. Then, the three-point estimation method is used to process the data, and the probability distribution of the unknown quantity is obtained by probabilistic power flow analysis. Finally, the probability distribution of each eigenvalue is obtained by analyzing the sensitivity of the characteristic roots to the voltage. Thus, the static stability of the system is judged. The applicability of proposed methodology is demonstrated by analyzing an integrated IEEE 14-bus power system and a Belgian 20-node gas system in this paper. (shrink)