White matter tracts are known to be susceptible to injury following concussion. The objective of this study was to determine whether contact play in sport could alter white matter metabolite levels in female varsity athletes independent of changes induced by long-term exercise. Metabolite levels were measured by single voxel proton magnetic resonance spectroscopy in the prefrontal white matter at the beginning and end of season in contact and non-contact varsity athletes. Sedentary women were scanned once, at a time equivalent to (...) the Off-Season time point. Metabolite levels in non-contact athletes did not change over a season of play, or differ from age matched sedentary women except that non-contact athletes had a slightly lower myo-inositol level. The contact athletes had lower levels of myo-inositol and glutamate, and higher levels of glutamine compared to both sedentary women and non-contact athletes. Lower levels of myo-inositol in non-contact athletes compared to sedentary women indicates long-term exercise may alter glial cell profiles in these athletes. The metabolite differences observed between contact and non-contact athletes suggest that non-contact athletes should not be used as controls in studies of concussion in high-impact sports because repetitive impacts from physical contact can alter white matter metabolite level profiles. It is imperative to use athletes engaged in the same contact sport as controls to ensure a matched metabolite profile at baseline. (shrink)

The painter "takes his body with him."Nevertheless, Renoir was looking at the sea.Close! stand close to me, Starbuck; let me look into a human eye.The painter takes his body with him—he looks at what he sees and what he sees looks back at him. Perception takes place in the exchange, in time and in the world, not only between people or between living things but also between "subject" and "object," between perceiver and perceived. In this exchange that Maurice Merleau-Ponty calls (...) "the chiasm"—"this mediation through reversal"—something direct and active takes place. Before we can know or say what we're seeing, before we divide what we see into things or kinds of things, before naming and measurement, assertion and... (shrink)

According to Heidegger, "mortals live in the speaking of language"—to respond genuinely to language is to bring human being into existence. The Indo-European root gen -, meaning "to beget"—with derivatives including "kin," "kind," "king," "generation," "gentle," "gender," "native," "nation," and "nature"—is an index to two central questions in Shakespeare's plays: "Are human beings, by nature, kind?" and "Are the gods kind?" King Lear finds himself in a world of gen - topsy-turvy. His response to language and to the absent gods (...) recalls us to our own mortal being. (shrink)