Paradoxically, DNA sequence polymorphisms in cancer risk loci rarely correlate with the expression of cancer genes. Therefore, the molecular mechanism underlying an individual's susceptibility to cancer has remained largely unknown. However, recent evaluations of the correlations between DNA methylation and gene expression levels across healthy and cancerous genomes have revealed enrichment of disease‐related DNA methylation variations within disease‐associated risk loci. Moreover, it appears that transcriptional enhancers embedded in cancer risk loci often contain DNA methylation sites that closely define the expression (...) of prominent cancer genes, despite the lack of significant correlations between gene expression levels and the surrounding disease‐associated polymorphic sequences. We suggest that DNA methylation variations may obscure the effect of co‐residing risk sequence alleles. Analysis of enhancer methylation data may help to reveal the regulatory circuits underlying predisposition to cancers and other common diseases.Editor's suggested further reading in BioEssays DNA methylation reprogramming in cancer: Does it act by re‐configuring the binding landscape of Polycomb repressive complexes? Abstract. (shrink)

PurposeTo present a generic empowerment ecology framework to guide the operation of Future Centers and to empower Future Center visitors to respond to the challenges facing them and develop and implement innovative solutions.Design/methodology/approachAn in‐depth case study was conducted in Be'er Sheva PISGA Future Center in the educational sector in Israel. Visits to a further 20 Future Centers around the world and a literature review helped to generalize the key findings and develop and validate the framework further.FindingsAlthough empowerment is not always (...) explicitly discussed in Future Centers, it is an important underlying philosophy. The framework developed in this research helps to ensure empowerment issues are systematically addressed and contains four perspectives: operating principles; resources; supporters and processes. These combine to form the empowerment ecology.Research limitations/implicationsThe empowerment ecology framework has been developed from observation predominantly in one Future Center. It should now be more fully tested and validated in other Future Centers.Practical implicationsThis paper provides a framework to help Future Center practitioners and other future oriented working environments stakeholders to explicitly address empowerment issues.Originality/valueThis paper provides a detailed description of the operation of a regionally focused Future Center in the educational sector. The paper presents a novel empowerment ecology framework for use in facilitated user‐centered collaborative working environments, such as Future Centers. (shrink)

In the current research, we examined whether ostracism and sexual objectification affect the tendency to blame the victim of sexual harassment. Previous research concerning victim blame examined the attribution of blame considering the characteristics of the victim, the perpetrator, and the relation between them. However, no research to date examined whether situational factors of the perceiver can affect their perception and judgment of blame. We propose that sexual objectification and ostracism may elicit empathy toward the victim, and in turn, reduce (...) victim blame. In two experimental studies, women were instructed to imagine interacting with a videotaped man who either gazed at their body, away from them, or at their face. Then, they were asked to read a newspaper article or watch a video portraying encounters in which the man's sexual advances continued after the woman expressed discomfort and lack of interest. In study 1, we found that sexually objectified women attributed less blame to the woman compared with the women who were treated well, with ostracized women falling in between and marginally different from both. In study 2, using mediation analysis we found an indirect effect such that sexually objectified women experienced greater empathy toward the victim, which was associated with reduced attribution of blame. It appears that greater similarity between the situation of the perceiver and the situation of the victim elicits greater empathy. This adds to the previous knowledge that personality similarities result in higher empathy. (shrink)