The plasmodium of _Physarum polycephalum_ is a unicellular and multinuclear giant amoeba with computational abilities. The plasmodium has been widely used as a model organism in the field of bio-computing; however, its ability to perform computation related to its biological nature itself in the essential sense has not yet been fully realized. Therefore, in this study, we focused on the phenomenon in which a plasmodium trapped in a closed space surrounded by repellent substances escapes from the field by changing its (...) own behavior rules. We demonstrated that this phenomenon is bio-computationally important in that it may enable the implementation of biological characteristics in computing. (shrink)