Cellular senescence is an anti‐proliferative program that restricts the propagation of cells subjected to different kinds of stress. Cellular senescence was initially described as a cell‐autonomous tumor suppressor mechanism that triggers an irreversible cell cycle arrest that prevents the proliferation of damaged cells at risk of neoplastic transformation. However, discoveries during the last decade have established that senescent cells can also impact the surrounding tissue microenvironment and the neighboring cells in a non‐cell‐autonomous manner. These non‐cell‐autonomous activities are, in part, mediated (...) by the selective secretion of extracellular matrix degrading enzymes, cytokines, chemokines and immune modulators, which collectively constitute the senescence‐associated secretory phenotype. One of the key functions of the senescence‐associated secretory phenotype is to attract immune cells, which in turn can orchestrate the elimination of senescent cells. Interestingly, the clearance of senescent cells seems to be critical to dictate the net effects of cellular senescence. As a general rule, the successful elimination of senescent cells takes place in processes that are considered beneficial, such as tumor suppression, tissue remodeling and embryonic development, while the chronic accumulation of senescent cells leads to more detrimental consequences, namely, cancer and aging. Nevertheless, exceptions to this rule may exist. Now that cellular senescence is in the spotlight for both anti‐cancer and anti‐aging therapies, understanding the precise underpinnings of senescent cell removal will be essential to exploit cellular senescence to its full potential. (shrink)

Durante años se ha venido demostrando que es necesario fomentar espacios de intercambio intergeneracional para la construcción de sociedades más solidarias e inclusivas. Partiendo de este marco, en el presente artículo se evalúa una experiencia intergeneracional llevada cabo en el entorno universitario donde estudiantes y personas mayores comparten sus miradas sobre la soledad a través de cartas. Para el análisis del material recopilado (18 cartas y 82 narrativas) se ha utilizado el software Iramuteq. Los resultados remarcan la propia metodología como (...) una nueva manera de relacionarse que posibilita el intercambio y el conocimiento mutuo necesario en una sociedad segregada. (shrink)

Spain has become one of the European epicenters of coronavirus (COVID-19), a virus that particularly affects the elderly, since this group accounts for the majority of hospitalized cases and has the highest mortality rates. Therefore, the aim of this research is to understand how elderly people represent and emotionally cope with COVID-19 during the days when the pandemic emerged in Spain. Using a qualitative methodology, a free association exercise elicited by the word “COVID-19” was completed by 115 participants (age range: (...) 60–85 years) from the North of Spain. Lexical analysis was used to analyze the content. The results revealed that the government and the mass media are criticized for failing to communicate a clear message, and for giving out information that is both insufficient and contradictory. However, participants are clear that it is essential to follow the guidelines of the scientists and doctors, which are represented as credible sources. However, when the state of alarm and the lockdown of all citizens was declared, most of the participants represented the risk as being associated with the elderly and the pandemic became something that might also affect their families. Due to these circumstances, negative emotions appear such as fear, nervousness, uncertainty, restlessness, and insecurity. Feelings of solitude and loneliness also emerged, and these are represented as being linked to death. These results indicate the need for governments to manage the current situation with the elderly by placing greater emphasis on social and inclusive policies to help alleviate the possible effects of the pandemic and the lockdown. (shrink)

En el contexto de a psiquiatría y la psicología clínica, el término "adicción" tradicionalmente ha estado unido al concepto de "dependencia" física y psíquica de "sustancias" (alcohol, cocaína, opiáceos, drogas sintéticas, medicamentos, etc.). La dependencia se define por un conjunto de síntomas cognoscitivos, de comportamiento y fisiológicos que indican, a pesar de la aparición de problemas significativos, que la persona continúa consumiendo la sustancia. Así pues, el diagnóstico clínico de dependencia necesita alguna sustancia concreta y para formalizarlo necesariamente requiere, según (...) los manuales diagnósticos al uso, de malestar clínicamente significativo, deterioro de la actividad laboral, social, o de otras áreas importantes de la actividad del individuo. (shrink)

La palabra "amor" tiene más de 215 millones de entradas en uno de los buscadores más populares de Internet y "love" más de 1.370 millones. Este elevado número de entradas bien pudiera reflejar las muy distintas concepciones que la gente tiene del amor y la importancia que adquiere en sus vidas. Si estudiamos algo más las fuentes que nos ofrece Internet, el amor en muchas ocasiones suele ir ligado al sexo, a menudo lleva la etiqueta de "romántico", pero también se (...) encuentra vinculado con la amistad o el compromiso, los celos, la pasión, la intimidad, el odio, el cariño, la infidelidad, la admiración, el respeto� Las encuestas y los estudios que se están haciendo desde la psicología empiezan a revelar algunos resultados interesantes. (shrink)

El objetivo del presente texto es realizar un acercamiento a las diferentes corrientes de pensamiento económico feminista en función de sus propuestas de redefinición del objeto de estudio de la economía; propuestas que pueden entenderse como intentos de deconstrucción de las dicotomías económico/no-económico, trabajo/no-trabajo propias de los marcos teóricos androcéntricos. Se identifican dos estrategias de deconstrucción, con diferentes implicaciones tanto para el ámbito de la teoría económica como para el del análisis empírico y la propuesta política. La primera de ellas (...) está basada en el descubrimiento y revalorización del “otro” económico, el trabajo doméstico. La segunda, en proporcionar un “término bisagra”, el de sostenibilidad de la vida, que permita trascender las dicotomías y a partir del cuál se revisan conceptos asociados, como el de trabajo. Finalmente, se argumentará que se está produciendo un desplazamiento teórico hacia esta última estrategia. (shrink)

The objective of this article is to provide a discussion that counters the infinite particle disappearance conclusion argued by Shackel, 417–433, 2018). In order to do this, clear criteria to disprove the results of the applications of his continuity principles are provided, in addition to the consideration of the fundamental Classical Mechanical principle of mass conservation as an independent and clear basis for this disproof.

Purpose This study aims to explore the main concerns and attitudes Basque adolescents have regarding online privacy. It analyzes their motivations for sharing private information and the kind of information they share. Likewise, it examines whether they consider the potential consequences of revealing certain information online and analyzes if there are any differences between the motivations and attitudes of young people from Gipuzkoa and Labourd. Design/methodology/approach For this study, three methods were combined to collect the data in 17 schools in (...) the Basque provinces of Gipuzkoa and Labourd: a survey carried out among 1,133 students, out of which 242 also completed a diary and 482 took part in discussion groups. Findings The data from this research does not fully support the “youth cultures of disclosure” in the Basque Country; however, some of these practices have been observed. Originality/value Time spent online by adolescents has increased sharply in recent years. This increase has brought with it concerns about youth’s level of awareness regarding online privacy. This is the first cross-border study conducted in the Basque Country addressing this topic. (shrink)

Violence in sexual-affective relationships among teens and young people is recognized as a social, educational, and health problem that has increased worldwide in recent years. Educational institutions, as central developmental contexts in adolescence, are key in preventing and responding to gender violence through implementing successful actions. In order to scientifically support that task, the research reported in this article presents and discusses a psycho-educational intervention focused on autobiographical memory reconstruction that proved to be successful in raising young women’s critical consciousness (...) about the force of the coercive dominant discourse upon sexual-affective experiences and memories. We examined among a sample of young women (n = 32, age range 17-30) whether reading a scientific text about love, the Radical Love book, modified autobiographical memories of violent sexual-affective relationships in line with preventing future victimization. This group was compared with a control group (n = 31, age range 17-30). Memory reports were collected before and after the reading and coded to analyze their content, both quantitatively and qualitatively. Memory quality features were assessed with the Memory Quality Questionnaire. A focus group was also conducted to examine the personal impact of the intervention on participants. Compared with controls, the experimental group had stronger critical memories (of episodes involving violence), an average decrease in positive emotions induced by recall, and an average increase in negative emotions. The results show the effectiveness of the reading intervention designed in relation to gender violence prevention, as they indicate the ability of the psycho-educational action to debilitate the force of the coercive dominant discourse in young women’s memories. The findings both advance knowledge on the reconstructive nature of autobiographical memories of violent sexual-affective relationships in female youth and indicate the potential of memory-based interventions as an instrument to prevent and reduce gender violence in school contexts. Teachers and teaching staff, and educational psychologists, among others, can benefit from these results by expanding the tools they have to address gender violence among female adolescents and youth. (shrink)

I explain what exactly constrains presupposition projection in compound sentences and argue that the presuppositions that do not project are conditionalized, giving rise to inferable conditional presuppositions. I combine elements of and which, together with an additional, independently motivated assumption, make it possible to construct an analysis that makes correct predictions. The core of my proposal is as follows: When a speaker felicitously utters a compound sentence whose constituent clauses require presuppositions, the hearer will infer that the speaker presupposes those (...) propositions, unless the sentence contains some element that makes the hearer realize that, if the speaker actually presupposed them, she would be either uninformative or inconsistent in her beliefs. In these cases, the propositions that would have been presupposed, had the clauses been uttered in isolation, will not be presupposed, i.e. the clausal presuppositions will not project. (shrink)

This study proposes and tests a model that integrates ethical leadership, internal social capital, and firm performance in small- and medium-sized family firms at different generational stages. Using the upper echelons theory and the social capital perspective of familiness, this study shows that ethical leadership can explain the effectiveness of certain behaviors in relation to family firm performance. Moreover, social capital helps spread a leader's business ethics to firm members, thus improving the family firm's performance. Our results show that founders' (...) personalities and identities determine high internal social capital, which decreases over generations. The study also shows that internal social capital is a communicative element crucial to ethical leadership, facilitating the absorption of the culture and values of the family in the firm. This powerful resource should be promoted and supported by coherent behavior over time by senior leaders. (shrink)

The objective of this study was to create and validate an instrument to measure the wellbeing of children in lockdown. As a response to the COVID-19 pandemic, and in the interest of maintaining social distancing, millions of people have been confined to their homes, including children, who have been withdrawn from school and barely able to leave their homes. Thus, it would be useful to evaluate, from a holistic perspective, the well-being of children under these challenging circumstances. The participants were (...) 1046 children 48.7% of which were boys and 50.7% girls, recruited in the Basque Country (Northern Spain). The survey, entitled, 'Well-being of Children in Lockdown" (WCL) is composed of six sub-scales: Emotions, Playful and creative activities, Education, Addictions, Routine, and Physical Activity. Exploratory factor analyses indicate that all the reliability indices were acceptable. The survey demonstrated adequate reliability (alpha=.804). We were thus able to confirm the validity of this simple instrument for evaluating the well-being of children aged between 4 and 12 years in lockdown situations.2. (shrink)

Rationale, aims and objectives Given the increasing prevalence of cataract and demand for cataract extraction surgery, patients must often wait to undergo this procedure. We validated a previously developed priority scoring system in terms of clinical variables, pre-intervention health status, appropriateness of surgery and gain in visual acuity (VA) and health-related quality of life (HRQoL).Methods Explicit prioritization criteria for cataract extraction created by a variation of the Research and Development (RAND) and University of California Los Angeles appropriateness methodology were retrospectively (...) applied to a prospective cohort of 5257 patients on waiting lists to undergo cataract by phacoemulsification at 17 hospitals in Spain. Demographic data, clinical data and data related to surgical technique were collected by trained ophthalmologists. Patients were evaluated by their ophthalmologist before the intervention and 6 weeks afterward. They also completed, by mail, the Visual Function Index (VF-14) before the intervention and 3 months afterward.Results High-priority patients experienced greater improvement in VA and HRQoL than those classified as intermediate or low-priority (P < 0.0001), even after adjusting by VA and the VF-14 score at baseline. The time to intervention was the same for high-priority patients as it was for intermediate and low-priority patients.Conclusions The priority score we developed identified patients most likely to experience the greatest improvements from cataract extraction. Use of this tool could provide a fairer and more rational way to prioritize patients for cataract extraction. (shrink)

RATIONALE AND AIMS: Total hip and knee replacements, usually, have long waiting lists. There are several prioritization tools for these kind of patients. A new tool should undergo a standardized validation process. The aim of the present study was to validate a new prioritization tool for primary hip and knee replacements. METHODS: We carried out a prospective study. Consecutive patients placed on the waiting list were eligible for the study. Patients included were mailed a questionnaire which included, among other questions, (...) the seven items of the priority tool and the Western Ontario and McMasters Universities Arthritis Index (WOMAC) specific questionnaire. The priority tool gives a score from 0 to 100 points, and three categories (urgent, preferent and ordinary). We studied the content and construct validity. We used Student's t-test or one-way analysis of variance. Correlational analysis was used to evaluate convergent and discriminate validity. RESULTS: The sample consisted of 838 patients (62.3% were female), with mean age of 70.2 years (SD 8.4). A total of 55.5% patients underwent knee replacement. Given that the tool was elaborated by patients and orthopaedic surgeons, it shows a good content validity. The priority score was statistically different (P < 0.001) among the three urgency categories created. The scores of the three WOMAC dimensions showed differences (P < 0.001) by the three urgency categories created. The correlations between the priority score and WOMAC dimensions were 0.79 (function), 0.69 (pain) and 0.51 (stiffness). The correlations between WOMAC items and items from priority tool were greater (0.47-0.69) between items measuring similar constructs than those measuring different constructs (0.27-0.49). These data are similar in both joints. CONCLUSIONS: Results support the validity of the prioritization tool to be used with patients waiting for hip or knee replacement. (shrink)

This article aims to adapt to Spanish the Relational Needs Satisfaction Scale and to test the factor structure with a clinical and a non-clinical sample. A total of 459 individuals completed the RNSS, a measure of life satisfaction and of psychological wellbeing. Results showed that the translation was adequate. An exploratory and confirmatory factor analysis was conducted followed by the test of three models that confirmed the five-factor structure and the second-order global factor proposed in the original study, and in (...) adaptations to other languages. The advantages and disadvantages of these models are discussed. Correlations of the RNSS with life satisfaction and psychological wellbeing measures were in the expected direction, providing evidence of convergent validity. The Spanish version of the RNSS is a valid and reliable measure of the construct it was intended to measure, though some improvements in item wording could be incorporated and tested. (shrink)

Since March 14, 2020, Spain has been in a state of alarm, due to the crisis created by the outbreak of COVID-19. This measure has led to strict levels of lockdown. This situation has led to an increase in anxiety levels among the younger population. For this reason, an intervention was carried out with university voluntary participants in order to help lower their anxiety levels. Specifically, a telematic workshop was implemented to teach emotional literacy and relaxation techniques combined with the (...) practice of the techniques in an autonomous manner. Anxiety measurements were taken before and after the workshop using the GAD7 scale. The results show that Jacobson's progressive relaxation techniques, Schultz's autogenous relaxation, abdominal relaxations and visualizations are effective in lowering the anxiety levels of university students being an alternative to pharmacotherapy. (shrink)