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Summary

Developmental Biology is the study of organisms’ life cycles from single cell to complex reproducing and aging multi-cellular organisms. It endeavours to explain phenomena such as: cellular differentiation (e.g. neurons vs. liver cells) and cellular aging, the development of gross morphology and anatomical structures (e.g. body shape and organs -eyes and limbs-), and the development of an organism as an integrated part of an eco-system (e.g. phenotypic plasticity). The philosophically relevant points, in addition to broader philosophy of science inquiries (e.g. confirmation and explanation) are those that have to do with the ontological status of biological kinds and with inter-level relations, specifically the integration of developmental biology with evolutionary biology and to a lesser extent, with ecology. Keeping this is in mind the subcategories within Developmental Biology can be grouped into three main themes: Evolution, Ecology and Ontology.    

Evolution

(Evolutionary-Developmental Biology, Developmental Constraints and Process Structuralism)

Ecology 

(Ecological Developmental Biology, Epigenetic Inheritance, Nature vs. Nurture and Innateness) 

and 

Ontology 

(Developmental Modularity, Developmental System Theory and Process Structuralism).

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  1. Developmental Biology as a Science of Dependent Co-Origination.Scott Gilbert - manuscript
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  2. Is the Neo-Aristotelian Concept of Organism Presupposed in Biology?Parisa Moosavi - 2020 - In Martin Hähnel (ed.), Aristotelian Naturalism: A Research Companion. Springer.
    According to neo-Aristotelian ethical naturalism, moral goodness is an instance of natural goodness, a kind of normativity supposedly already present in nature in the biological realm of non-human living things. Proponents of this view appeal to Michael Thompson’s conception of a life-form--the form of a living organism--to give an account of natural goodness. However, although neo-Aristotelians call themselves naturalists, they hardly ever consult the science of biology to defend their commitments regarding biological organisms. This has led many critics to argue (...)
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  3. Levels of Organization in the Biological Sciences.Daniel Stephen Brooks, James DiFrisco & William C. Wimsatt (eds.) - forthcoming - MIT Press.
    The subject of this edited volume is the idea of levels of organization: roughly, the idea that the natural world is segregated into part-whole relationships of increasing spatiotemporal scale and complexity. The book comprises a collection of essays that raise the idea of levels into its own topic of analysis. Owing to the wide prominence of the idea of levels, the scope of the volume is aimed at theoreticians, philosophers, and practicing researchers of all stripes in the life sciences. The (...)
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  4. Control by Viability in a Chemotherapy Cancer Model.M. Serhani, H. Essaadi, K. Kassara & A. Boutoulout - 2019 - Acta Biotheoretica 67 (3):177-200.
    The aim of this study is to provide a feedback control, called the Chemotherapy Protocol Law, with the purpose to keep the density of tumor cells that are treated by chemotherapy below a “tolerance level” L_c, while retaining the density of normal cells above a “healthy level” N_c. The mathematical model is a controlled dynamical system involving three nonlinear differential equations, based on a Gompertzian law of cell growth. By evoking viability and set-valued theories, we derive sufficient conditions for the (...)
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  5. Beeing & Time: Kiss of Chemoreception & the Bug in Dasein's Mouth.Virgil W. Brower - 2014 - In Laurence Talairach-Vielmas & Marie Bouchet (eds.), Insects in Literature & the Arts. Brussels, Belgium: pp. 197-217.
    "Brower explores the way philosophers were inspired by entomological social systems and communication to reflect on human psyche, social behavior, community organization, communication, and inter-individual relationships. His essay rehearses the swarms of insects embedded in contemporary philosophy and literary theory, not only showing how many of the major concepts (or philosophemes) in continental philosophy – sexuality, politics, thinking, time, interdependence, and language – draw lessons from the world of insects, but also illustrating again how the insect world spurred human reflection.".
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  6. Developmental Roles and Evolutionary Significance of AMPA‐Type Glutamate Receptors.Shinobu Hirai, Kohji Hotta & Haruo Okado - 2018 - Bioessays 40 (9):1800028.
    Organogenesis and metamorphosis require the intricate orchestration of multiple types of cellular interactions and signaling pathways. Glutamate (Glu) is an excitatory extracellular signaling molecule in the nervous system, while Ca2+ is a major intracellular signaling molecule. The first Glu receptors to be cloned are Ca2+‐permeable receptors in mammalian brains. Although recent studies have focused on Glu signaling in synaptic mechanisms of the mammalian central nervous system, it is unclear how this signaling functions in development. Our recent article demonstrated that Ca2+‐permeable (...)
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  7. The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity.Snehal N. Chaudhari & Edward T. Kipreos - 2018 - Bioessays 40 (8):1800005.
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  8. Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity.Simone Ecker, Vera Pancaldi, Alfonso Valencia, Stephan Beck & Dirk S. Paul - 2018 - Bioessays 40 (2):1700148.
    Epigenetic and transcriptional variability contribute to the vast diversity of cellular and organismal phenotypes and are key in human health and disease. In this review, we describe different types, sources, and determinants of epigenetic and transcriptional variability, enabling cells and organisms to adapt and evolve to a changing environment. We highlight the latest research and hypotheses on how chromatin structure and the epigenome influence gene expression variability. Further, we provide an overview of challenges in the analysis of biological variability. An (...)
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  9. Multicellular Individuality: The Case of Bacteria.Rafael Ventura - 2019 - Biological Theory 14 (2):131-140.
    Recent attention to complex group-level behavior amongst bacteria has led some to conceive of multicellular clusters of bacteria as individuals. In this article, I assess these recent claims by first drawing a distinction between two concepts of individuality: physiological and evolutionary. I then survey cases that are representative of three different modes of growth: myxobacteria, Bacillus subtilis, and cyanobacteria. A closer look at these cases indicates that multicellular individuality among bacteria is remarkably complex. Physiologically, the three cases of multicellular clusters (...)
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  10. Targeting the Spleen as an Alternative Site for Hematopoiesis.Christie Short, Hong K. Lim, Jonathan Tan & Helen C. O'Neill - 2019 - Bioessays 41 (5):1800234.
    Bone marrow is the main site for hematopoiesis in adults. It acts as a niche for hematopoietic stem cells (HSCs) and contains non‐hematopoietic cells that contribute to stem cell dormancy, quiescence, self‐renewal, and differentiation. HSC also exist in resting spleen of several species, although their contribution to hematopoiesis under steady‐state conditions is unknown. The spleen can however undergo extramedullary hematopoiesis (EMH) triggered by physiological stress or disease. With the loss of bone marrow niches in aging and disease, the spleen as (...)
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  11. How Does Inflammation‐Induced Hyperglycemia Cause Mitochondrial Dysfunction in Immune Cells?Gustav Niekerk, Tanja Davis, Hugh‐George Patterton & Anna‐Mart Engelbrecht - 2019 - Bioessays 41 (5):1800260.
    Inflammatory mediators have an established role in inducing insulin resistance and promoting hyperglycemia. In turn, hyperglycemia has been argued to drive immune cell dysfunction as a result of mitochondrial dysfunction. Here, the authors review the evidence challenging this view. First, it is pointed out that inflammatory mediators are known to induce altered mitochondrial function. In this regard, critical care patients suffer both an elevated inflammatory tone as well as hyperglycemia, rendering it difficult to distinguish between the effects of inflammation and (...)
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  12. Why the Lipid Divide? Membrane Proteins as Drivers of the Split Between the Lipids of the Three Domains of Life.Victor Sojo - 2019 - Bioessays 41 (5):1800251.
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  13. Stress‐Induced Evolutionary Innovation: A Mechanism for the Origin of Cell Types.Günter P. Wagner, Eric M. Erkenbrack & Alan C. Love - 2019 - Bioessays 41 (4):1800188.
    Understanding the evolutionary role of environmentally induced phenotypic variation (i.e., plasticity) is an important issue in developmental evolution. A major physiological response to environmental change is cellular stress, which is counteracted by generic stress reactions detoxifying the cell. A model, stress‐induced evolutionary innovation (SIEI), whereby ancestral stress reactions and their corresponding pathways can be transformed into novel structural components of body plans, such as new cell types, is described. Previous findings suggest that the cell differentiation cascade of a cell type (...)
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  14. The Nature of Programmed Cell Death.Pierre M. Durand & Grant Ramsey - 2019 - Biological Theory 14 (1):30-41.
    In multicellular organisms, cells are frequently programmed to die. This makes good sense: cells that fail to, or are no longer playing important roles are eliminated. From the cell’s perspective, this also makes sense, since somatic cells in multicellular organisms require the cooperation of clonal relatives. In unicellular organisms, however, programmed cell death poses a difficult and unresolved evolutionary problem. The empirical evidence for PCD in diverse microbial taxa has spurred debates about what precisely PCD means in the case of (...)
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  15. Cell Fate and Developmental Regulation Dynamics by Polycomb Proteins and 3D Genome Architecture.Vincent Loubiere, Anne-Marie Martinez & Giacomo Cavalli - 2019 - Bioessays 41 (3):1800222.
    Targeted transitions in chromatin states at thousands of genes are essential drivers of eukaryotic development. Therefore, understanding the in vivo dynamics of epigenetic regulators is crucial for deciphering the mechanisms underpinning cell fate decisions. This review illustrates how, in addition to its cell memory function, the Polycomb group of transcriptional regulators orchestrates temporal, cell and tissue‐specific expression of master genes during development. These highly sophisticated developmental transitions are dependent on the context‐ and tissue‐specific assembly of the different types of Polycomb (...)
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  16. Veins and Arteries Build Hierarchical Branching Patterns Differently: Bottom‐Up Versus Top‐Down.Kristy Red-Horse & Arndt F. Siekmann - 2019 - Bioessays 41 (3):1800198.
    A tree‐like hierarchical branching structure is present in many biological systems, such as the kidney, lung, mammary gland, and blood vessels. Most of these organs form through branching morphogenesis, where outward growth results in smaller and smaller branches. However, the blood vasculature is unique in that it exists as two trees (arterial and venous) connected at their tips. Obtaining this organization might therefore require unique developmental mechanisms. As reviewed here, recent data indicate that arterial trees often form in reverse order. (...)
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  17. Cell‐Cycle‐Dependent Regulation of Cell Adhesions: Adhering to the Schedule.Yitong Li & Keith Burridge - 2019 - Bioessays 41 (1):1800165.
    Focal adhesions disassemble during mitosis, but surprisingly little is known about how these structures respond to other phases of the cell cycle. Three recent papers reveal unexpected results as they examine adhesions through the cell cycle. A biphasic response is detected where focal adhesions grow during S phase before disassembly begins early in G2. In M phase, activated integrins at the tips of retraction fibers anchor mitotic cells, but these adhesions lack the defining components of focal adhesions, such as talin, (...)
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  18. Reconsidering Morphology Through an Experimental Case Study.Alessandro Minelli, Rocco Micciolo, Mara Rosa, Paolo Chistè, Luisa Canal & Liliana Albertazzi - 2017 - Biological Theory 12 (3):131-141.
    This study analyzes shells of marine gastropods of a zoological museum and the Latin epithets expressing perceptual and connotative attributes that they have received in the standard, Linnaean nomenclature. Making use of the Osgood semantic differential, we presented the subjects with digital 3-D reproductions of the shell specimens to be subjectively evaluated according to 17 pairs of attributes. The results show that, overall, the subjective evaluations given by the subjects are consistent, which suggests that an intersubjective characterization of the shells (...)
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  19. Discrete Mesh Approach in Morphogenesis Modelling: The Example of Gastrulation.E. Promayon, A. Lontos & J. Demongeot - 2016 - Acta Biotheoretica 64 (4):427-446.
    Morphogenesis is a general concept in biology including all the processes which generate tissue shapes and cellular organizations in a living organism. Many hybrid formalizations have been proposed for modelling morphogenesis in embryonic or adult animals, like gastrulation. We propose first to study the ventral furrow invagination as the initial step of gastrulation, early stage of embryogenesis. We focus on the study of the connection between the apical constriction of the ventral cells and the initiation of the invagination. For that, (...)
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  20. Cancer Ecology: The Intracellular Interactome Makes Little Sense Without the Intercellular One.Andrew Moore - 2018 - Bioessays 40 (11):1800202.
  21. TGF‐Β Control of Adaptive Immune Tolerance: A Break From Treg Cells.Ming Liu & Shun Li - 2018 - Bioessays 40 (11):1800063.
    The vertebrate adaptive immune system has well defined functions in maintaining tolerance to self‐tissues. Suppression of autoreactive T cells is dependent on the regulatory cytokine transforming growth factor‐β (TGF‐β) and regulatory T (Treg) cells, a distinct T cell lineage specified by the transcription factor Foxp3. Although TGF‐β promotes thymic Treg (tTreg) cell development by repressing T cell clonal deletion and peripheral Treg cell differentiation by inducing Foxp3 expression, a recent study shows that TGF‐β suppresses autoreactive T cells independent of Foxp3+ (...)
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  22. An Emerging System to Study Photosymbiosis, Brain Regeneration, Chronobiology, and Behavior: The Marine Acoel Symsagittifera Roscoffensis.Enrique Arboleda, Volker Hartenstein, Pedro Martinez, Heinrich Reichert, Sonia Sen, Simon Sprecher & Xavier Bailly - 2018 - Bioessays 40 (10):1800107.
  23. Formaliser le vivant : lois, théories, modèles.Franck Varenne - 2010 - Paris, France: Hermann.
    Peut-on formaliser le vivant ? Peut-on réduire une plante à une simple formule mathématique ? Goethe ne l’aurait pas admis. Pour beaucoup encore, cette question ne se pose même pas tant elle peut sembler provocante et contre-nature. Dans une perspective à la fois historique et épistémologique, ce livre rend compte de travaux contemporains qui ont pourtant tous tenté de braver cet interdit. C’est en grande partie sur ce terrain, hautement problématique, que, dans les premières décennies du XXe siècle, on voit (...)
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  24. The Actomyosin Cytoskeleton Drives Micron‐Scale Membrane Remodeling In Vivo Via the Generation of Mechanical Forces to Balance Membrane Tension Gradients.Seham Ebrahim, Jian Liu & Roberto Weigert - 2018 - Bioessays 40 (9):1800032.
    The remodeling of biological membranes is crucial for a vast number of cellular activities and is an inherently multiscale process in both time and space. Seminal work has provided important insights into nanometer‐scale membrane deformations, and highlighted the remarkable variation and complexity in the underlying molecular machineries and mechanisms. However, how membranes are remodeled at the micron‐scale, particularly in vivo, remains poorly understood. Here, we discuss how using regulated exocytosis of large (1.5–2.0 μm) membrane‐bound secretory granules in the salivary gland (...)
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  25. Sex Differences in Early Embryogenesis: Inter‐Chromosomal Regulation Sets the Stage for Sex‐Biased Gene Networks.Nora Engel - 2018 - Bioessays 40 (9):1800073.
    Sex‐specific transcriptional and epigenomic profiles are detectable in the embryo very soon after fertilization. I propose that in male (XY) and female (XX) pre‐implantation embryos sex chromosomes establish sexually dimorphic interactions with the autosomes, before overt differences become apparent and long before gonadogenesis. Lineage determination restricts expression biases between the sexes, but the epigenetic differences are less constrained and can be perpetuated, accounting for dimorphisms that arise later in life. In this way, sexual identity is registered in the epigenome very (...)
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  26. Mathematical Model and Simulation of Retina and Tectum Opticum of Lower Vertebrates.U. an der Heiden & G. Roth - 1987 - Acta Biotheoretica 36 (3):179-212.
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  27. Sex Cells Through the Phyla. Germilne Development. Ciba Foundation Symposium 182 (1994). Edited by Joan Marsh and Jamie Goode. J. Wiley & Sons, Chichester. Pp. IX+321. £47.50. Isbn 0471 942642. [REVIEW]Paul Lasko - 1994 - Bioessays 16 (12):939-940.
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  28. Splitting: The Difference. Chromosome Segregation and Aneuploidy . Edited by BALDEV K. VIG. . Springer Verlag, NATO AS1 Series . 4. [REVIEW]Duncan J. Clarke - 1994 - Bioessays 16 (11):857-857.
  29. Radical Solutions and Cultural Problems: Could Free Oxygen Radicals Be Responsible for the Impaired Development of Preimplantation Mammalian Embryos in Vitro?Martin H. Johnson & Mohammad H. Nasresfahani - 1994 - Bioessays 16 (1):31-38.
    A major obstacel to the study of mammalian development, and to the practical application of knowledge gained from it in the clinic during therapeutic in vitro fertilisation and embryo transfer (IVF‐ET), is the propensity of embryos to become retarded or arrested during their culture in vitro. The precise developmental cell cycle in which embryos arrest or delay is characteristic for the species and coincides with the earliest period of embryonic gene expression. Much evidence reviewed here implicates free oxygen radicals (FORs) (...)
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  30. Asymmetric Segregation of Aged Spindle Pole Bodies During Cell Division: Mechanisms and Relevance Beyond Budding Yeast?Jette Lengefeld & Yves Barral - 2018 - Bioessays 40 (8):1800038.
    Asymmetric cell division generates cell diversity and contributes to cellular aging and rejuvenation. Here, we review the molecular mechanisms enabling budding yeast to recognize spindle pole bodies (SPB, centrosome equivalent) based on their age, and guide their non‐random mitotic segregation: SPB inheritance requires the distinction of old from new SPBs and is regulated by the SPB‐inheritance network (SPIN) and the mitotic exit network (MEN). The SPIN marks the pre‐existing SPB as old and the MEN recognizes these marks translating them into (...)
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  31. Cells in the Non‐Uniform Magnetic World: How Cells Respond to High‐Gradient Magnetic Fields.Vitalii Zablotskii, Tatyana Polyakova & Alexandr Dejneka - 2018 - Bioessays 40 (8):1800017.
    Imagine cells that live in a high‐gradient magnetic field (HGMF). Through what mechanisms do the cells sense a non‐uniform magnetic field and how such a field changes the cell fate? We show that magnetic forces generated by HGMFs can be comparable to intracellular forces and therefore may be capable of altering the functionality of an individual cell and tissues in unprecedented ways. We identify the cellular effectors of such fields and propose novel routes in cell biology predicting new biological effects (...)
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  32. Primary Cilia Reconsidered in the Context of Ciliopathies: Extraciliary and Ciliary Functions of Cilia Proteins Converge on a Polarity Theme?Kiet Hua & Russell J. Ferland - 2018 - Bioessays 40 (8):1700132.
    Once dismissed as vestigial organelles, primary cilia have garnered the interest of scientists, given their importance in development/signaling, and for their implication in a new disease category known as ciliopathies. However, many, if not all, “cilia” proteins also have locations/functions outside of the primary cilium. These extraciliary functions can complicate the interpretation of a particular ciliopathy phenotype: it may be a result of defects at the cilium and/or at extraciliary locations, and it could be broadly related to a unifying cellular (...)
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  33. Archaea‐First and the Co‐Evolutionary Diversification of Domains of Life.James T. Staley & Gustavo Caetano-Anollés - 2018 - Bioessays 40 (8):1800036.
    The origins and evolution of the Archaea, Bacteria, and Eukarya remain controversial. Phylogenomic‐wide studies of molecular features that are evolutionarily conserved, such as protein structural domains, suggest Archaea is the first domain of life to diversify from a stem line of descent. This line embodies the last universal common ancestor of cellular life. Here, we propose that ancestors of Euryarchaeota co‐evolved with those of Bacteria prior to the diversification of Eukarya. This co‐evolutionary scenario is supported by comparative genomic and phylogenomic (...)
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  34. Stem Cell Epistemological Issues. Chapter in Charbord P and Durand C (Eds) Stem Cell Biology and Regenerative Medicine.Lucie Laplane - 2015 - River Publishers.
    This chapter brings a philosophical perspective to the concept of stem cell. Three general questions both clarify the concept of stem cell and emphasize its ambiguities: (1) How should we define stem cells? (2) What makes them different from non-stem cells? (3) What is their ontology? (i.e. what kind of property is “stemness”?) Following this last question, the Chapter distinguishes four conceptions of stem cells and highlights their respective consequences for the cancer stem cell theory. Determining what kind of property (...)
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  35. Mitochondrial Outer Membrane Channels: Emerging Diversity in Transport Processes.Thomas Becker & Richard Wagner - 2018 - Bioessays 40 (7):1800013.
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  36. Synapse Pruning: Mitochondrial ROS with Their Hands on the Shears.James N. Cobley - 2018 - Bioessays 40 (7):1800031.
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  37. Endothelial Metabolic Control of Lymphangiogenesis.Pengchun Yu, Guosheng Wu, Heon-Woo Lee & Michael Simons - 2018 - Bioessays 40 (6):1700245.
  38. Novel Channels of the Outer Membrane of Mitochondria: Recent Discoveries Change Our View.Vanessa Checchetto & Ildiko Szabo - 2018 - Bioessays 40 (6):1700232.
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  39. Three Distinct Types of Microautophagy Based on Membrane Dynamics and Molecular Machineries.Masahide Oku & Yasuyoshi Sakai - 2018 - Bioessays 40 (6):1800008.
    Microautophagy is originally defined as lysosomal (vacuolar) membrane dynamics to directly enwrap and transport cytosolic components into the lumen of the lytic organelle. Molecular details of microautophagy had remained unknown until genetic studies in yeast identified a set of proteins required for the process. Subsequent studies with other experimental model organisms resulted in a series of discoveries that accompanied an expansion of the definition of microautophagy to also encompass endosomal membrane dynamics. These findings, however, still impose puzzling, non‐integrated images as (...)
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  40. Demarcation of Viral Shelters Results in Destruction by Membranolytic GTPases: Antiviral Function of Autophagy Proteins and Interferon‐Inducible GTPases.Hailey M. Brown, Scott B. Biering, Allen Zhu, Jayoung Choi & Seungmin Hwang - 2018 - Bioessays 40 (6):1700231.
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  41. Physical Limits on the Precision of Mitotic Spindle Positioning by Microtubule Pushing Forces.Jonathon Howard & Carlos Garzon-Coral - 2017 - Bioessays 39 (11):1700122.
    Tissues are shaped and patterned by mechanical and chemical processes. A key mechanical process is the positioning of the mitotic spindle, which determines the size and location of the daughter cells within the tissue. Recent force and position-fluctuation measurements indicate that pushing forces, mediated by the polymerization of astral microtubules against­ the cell cortex, maintain the mitotic spindle at the cell center in Caenorhabditis elegans embryos. The magnitude of the centering forces suggests that the physical limit on the accuracy and (...)
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  42. Nanog Expression in Embryonic Stem Cells - An Ideal Model System to Dissect Enhancer Function.Steven Blinka & Sridhar Rao - 2017 - Bioessays 39 (12):1700086.
    Embryonic stem cells are derived from the preimplantation embryo and can differentiate into virtually any other cell type, which is governed by lineage specific transcriptions factors binding to cis regulatory elements to mediate changes in gene expression. The reliance on transcriptional regulation to maintain pluripotency makes ESCs a valuable model to study the role of distal CREs such as enhancers in modulating gene expression to affect cell fate decisions. This review will highlight recent advance on transcriptional enhancers, focusing on studies (...)
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  43. How to Lose the Plasmalemma? Lessons From Ciliates, Dinoflagellates and Euglenids.Andrzej Bodył - 2017 - Bioessays 39 (11):1700149.
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  44. The Function of the Golgi Ribbon Structure - An Enduring Mystery Unfolds!Prajakta Gosavi & Paul A. Gleeson - 2017 - Bioessays 39 (11):1700063.
    The Golgi apparatus in vertebrate cells consists of individual Golgi stacks fused together in a continuous ribbon structure. The ribbon structure per se is not required to mediate the classical functions of this organelle and the relevance of the “ribbon” structure has been a mystery since first identified ultrastructurally in the 1950s. Recent advances recognize a role for the Golgi apparatus in a range of cellular processes, some mediated by signaling networks which are regulated at the Golgi. Here we review (...)
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  45. Linking Mitochondria and Synaptic Transmission: The CB1 Receptor.Marie-Ange Djeungoue-Petga & Etienne Hebert-Chatelain - 2017 - Bioessays 39 (12):1700126.
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  46. Too Much Eukaryote LGT.William F. Martin - 2017 - Bioessays 39 (12):1700115.
    The realization that prokaryotes naturally and frequently disperse genes across steep taxonomic boundaries via lateral gene transfer gave wings to the idea that eukaryotes might do the same. Eukaryotes do acquire genes from mitochondria and plastids and they do transfer genes during the process of secondary endosymbiosis, the spread of plastids via eukaryotic algal endosymbionts. From those observations it, however, does not follow that eukaryotes transfer genes either in the same ways as prokaryotes do, or to a quantitatively similar degree. (...)
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  47. Group Therapy or Mass Suicide? The Sharing of Cellular Damage Between Members of a Bacterial Community.David E. Whitworth - 2017 - Bioessays 39 (12):1700178.
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  48. Cell Size Control Via an Unstable Accumulating Activator and the Phenomenon of Excess Mitotic Delay.Nicholas Rhind - 2018 - Bioessays 40 (2):1700184.
    Unstable Accumulating Activator models for cellular size control propose an activator that accumulates in a size-dependent manner and triggers cell cycle progression once it has reached a certain threshold. Having a short half life makes such an activator responsive to changes in cell size and makes specific predictions for how cells respond to perturbation. In particular, it explains the curious phenomenon of excess mitotic delay. Excess mitotic delay, first observed in Tetrahymena in the '50s, is a phenomenon in which a (...)
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  49. The Diversification of Early Emerging Metazoans: A Window Into the Evolution of Animal Multicellularity.Roger Revilla-I.-Domingo & Oleg Simakov - 2018 - Bioessays 40 (5):1800029.
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  50. Identifying Human Naïve Pluripotent Stem Cells − Evaluating State‐Specific Reporter Lines and Cell‐Surface Markers.Amanda J. Collier & Peter J. Rugg-Gunn - 2018 - Bioessays 40 (5):1700239.
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