5 found
Janine Guespin-Michel [3]Janine F. Guespin-Michel [2]
  1.  14
    Defining Integrative Biology.Camille Ripoll, Janine Guespin-Michel, Vic Norris & Michel Thellier - 1998 - Complexity 4 (2):19-20.
  2.  62
    What Science for What Democracy?Janine Guespin-Michel - 2012 - Scientiae Studia 10 (SPE):95-102.
    The transformations undergone by research and science in the name of the so called "knowledge economy" cover the decisions of scientific policies and the "management" of research, and also the meaning of scientific activities (devoted to innovation) and even more fundamentally the very structure of the sciences (transformed to technosciences). The science that is contributing to capitalist competitiveness (and to the current economic crisis) is not the same as that which would be able to contribute "to the conception and democratic (...)
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  3.  17
    Positive Feedback Circuits and Adaptive Regulations in Bacteria.Janine Guespin-Michel & Marcelle Kaufman - 2001 - Acta Biotheoretica 49 (4):207-218.
    The mechanisms by which bacteria adapt to changes in their environment involve transcriptional regulation in which a transcriptional regulator responds to signal(s) from the environment and regulates (positively or negatively) the expression of several genes or operons. Some of these regulators exert a positive feedback on their own expression. This is a necessary (although not sufficient) condition for the occurrence of multistationarity. One biological consequence of multistationarity may be epigenetic modifications, a hypothesis unusual to microbiologists, in spite of some well-known (...)
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  4.  34
    Epigenesis and Dynamic Similarity in Two Regulatory Networks in Pseudomonas Aeruginosa.Janine F. Guespin-Michel, Gilles Bernot, Jean Paul Comet, Annabelle Mérieau, Adrien Richard, Christian Hulen & Benoit Polack - 2004 - Acta Biotheoretica 52 (4):379-390.
    Mucoidy and cytotoxicity arise from two independent modifications of the phenotype of the bacterium Pseudomonas aeruginosa that contribute to the mortality and morbidity of cystic fibrosis. We show that, even though the transcriptional regulatory networks controlling both processes are quite different from a molecular or mechanistic point of view, they may be identical from a dynamic point of view: epigenesis may in both cases be the cause of the acquisition of these new phenotypes. This was highlighted by the identity of (...)
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  5.  14
    Evolution of Prokaryotes: A Kuhnian Scientific Revolution.Janine F. Guespin-Michel - 1997 - Acta Biotheoretica 45 (3-4):221-226.
    The conviction, due to previous failures, that bacteriology and darwinism were incompatible, has postponed the application of molecular phylogenesis to bacteria. But once introduced, this new field has led to a profound revolution of this science. A stable classification of the bacteria is at last possible; a new domain, the Archae, as distant from the Bacteria as from the Eukarya, has been discovered; noncultivable new species can be identified from the environment. It may even be possible to unravel the pathway (...)
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