The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert Advisory Group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since (...) the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs Programme. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating and integrating evidence to identify causes of human cancer. The advancements adopted include strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention. (shrink)

Bd. 1. Absicht -Gemeinwohl -- Bd. 2. Gerechtigkeit-Praxis -- Bd. 3. Quantität-Zweifel.

Bd. 1 Das Absolute-Gesellschaft.-Bd.2 Gesetz-Relation.

Why would Rene Descartes, the father of modern rationalist philosophy, choose "meditations" -- a term and genre associated with religious discourse and practice -- for the title of his magnum opus that lays the metaphysical foundations for his reform of all knowledge, including mathematics and sciences? Why did he believe that the immortality of the soul and the existence of God, which the Meditations on First Philosophy set out to demonstrate, can only be made self-evident through meditating? These are the (...) question that Christopher Wild's book answers. Descartes discovered the "foundations of a marvelous science" through a dramatic conversion in southern Germany in the winter of 1619. The spiritual and cognitive exercises, derived from ancient philosophy and the Christian meditative tradition, which Descartes deployed in the Meditations, enable readers to discover metaphysical truths with the same degree of self-evidence with which Descartes did during his own conversion. Descartes' meditative turn, Wild argues, brings to a culmination a life-long preoccupation with the practice or craft of thinking, known as Cartesian method. By joining meditation to method the Meditations becomes the founding document for a Cartesian "art of turning," a new practice of both thought and life. (shrink)