This paper presents a challenge to Eurocentric world history on the grounds that it reifies and exaggerates the role of the West in the creation of modernity, while simultaneously ignoring India's seminal contributions. The groundwork is prepared in the first three sections, which refute the parochial biases of Eurocentrism by revealing India's impressive early developmental record and its place near the center of a nascent global economy. The paper culminates in an approach that places the "dialogue of civilizations" center-stage of (...) progressive world history, which is formulated as an antidote to parochial Eurocentric world history. This entails an extensive discussion of two key contributions that India made in enabling the rise of the modern West. These comprise the dissemination of Indian industrial methods that enabled the British industrial revolution on the one hand, and the transmission of Indian mathematical ideas that helped promote the European scientific revolution on the other hand. Moreover, this discussion is coupled with two speculative counterfactual historical scenarios. They are: first, that in the absence of British imperialism which sought to "contain" Indian development, India might have gone on to make the breakthrough to modernity, and second, that in the absence of Indian (as well as Chinese, African and Middle Eastern) help, the West might not have made the breakthrough to modernity. But whatever the veracity of such counterfactuals may or may not be, the ultimate upshot of the argument presented in this paper reveals that Eurocentrism's central claim - that the West made the breakthrough to modernity all by itself - can no longer hold true. (shrink)

The activation of leukocytes by bacterial cell wall lipopolysaccharide (LPS) contributes to the pathogenesis of septic shock. It is well established that, in the presence of plasma LPS‐binding protein (LBP), LPS binds with high affinity to CD14. The binding of LPS to CD14 has been associated with the activation of cells, although available evidence indicates that CD14 itself does not transduce intracellular signalling. The physiological function of this interaction is to promote host defense mechanisms of cells to combat the infection (...) and clear LPS from the circulation. At higher concentrations of LPS, however, the activation of cells can take place in the absence of LBP and CD14, presumably through a distinct low‐affinity signalling LPS receptor. On the evidence published by us and others, we propose that in neutrophils, and possibly other leukocytes, L‐selectin can act as a low‐affinity LPS receptor. (shrink)

Pt. 1. Purva paksha (examination of my opponents' positions) -- pt. 2. Uttara paksha (my response).

IntroductionCognition generally declines gradually over time due to progressive degeneration of the brain, leading to dementia and eventual loss of independent functions. The rate of regression varies among the six cognitive domains. Current modality of cognitive assessment using neuropsychological paper-and-pencil screening tools for cognitive impairment such as the Montreal Cognitive Assessment has limitations and is influenced by age. Virtual reality is considered as a potential alternative tool to assess cognition. A novel, fully immersive automated VR system has been developed to (...) assess the six cognitive domains. As cognition is associated with age, VR performance is postulated to vary with age using this system.AimsThis is a feasibility study to evaluate the VR performance of cognitively healthy adults aged between 35 and 74 years old, based on the performance score and completion time using the CAVIRE system.MethodsConducted in a public primary care clinic in Singapore, 25 multi-ethnic Asian adults were recruited in each of the four age groups in years: 35–44; 45–54; 55–64, and 65–74. The eligibility criteria included a MoCA score of 26 or higher to reflect normal cognition and understanding English instructions. They completed common daily activities ranging from brushing teething to shopping, across 13 VR segments. Their performances scores and completion time were automatically computed by the CAVIRE system. These VR performance indices were compared across the four age groups using one-way ANOVA, F-test of the hypothesis, followed by pair-wise comparisons in the event of a significant F-test.ResultsOne participant dropped out from Group 1. The demographic characteristics of 99 participants were similar across the 4 age groups. Overall, younger participants in Groups 1 and 2 attained higher VR performance scores and shorter completion time, compared to those in Groups 3 and 4, in all six cognitive domains.ConclusionThe CAVIRE VR performance scores and completion time significantly differ between the younger and older Asian participants with normal cognition. Enhancements to the system are needed to establish the age-group specific normal performance indices. (shrink)

Amy Sonnie and James Tracy’sHillbilly Nationalists, Urban Race Rebels, and Black Power, Dan Berger’s anthologyThe Hidden 1970sand Jefferson Cowie’sStayin’ Alive, in different ways, articulate an understanding of the political ferment that gripped the United States in the late 1960s and 1970s and its complex legacy for those struggling to change the world today. While Cowie provides a broad-brush if ultimately flawed overview of labour’s declining influence during the 1970s, Sonnie and Tracy focus their attention on five radical organisations that challenged (...) deep divisions of race to condemn inequality and oppression, and Berger similarly encompasses contributions evaluating the impact of a variety of left organisations including the Puerto Rican nationalist movement, indigenous and Black nationalist quests to establish self-determination, and the extraordinary Sojourner Truth Organization. This review critically evaluates the strengths and weaknesses of the arguments made by Sonnie and Tracy, Berger and Cowie and suggests how they may be helpful for future struggle. (shrink)