This article addresses the growing industry of retail socially responsible investment (SRI) profiled mutual funds. Very few previous studies have examined the final consumer of SRI profiled mutual funds. Therefore, the purpose of this study was to, in an exploratory manner, examine the impact of a number of pro-social, financial performance, and socio-demographic variables on SRI behavior in order to explain why investors choose to invest different proportions of their investment portfolio in SRI profiled funds. An ordinal logistic regression analysis (...) on 528 private investors revealed that two of the three pro-social variables had a positive impact on how much the consumer invested in SRI profiled funds. Moreover, there was proof of a non-altruistic motive for investing in SRI as consumers who perceive that financial return of SRI is equal or better than "regular" mutual funds, invested a greater proportion of their portfolio in SRI profiled mutual funds. Furthermore, the results showed that women and better-educated investors were more likely to invest a greater proportion of their investment portfolio in SRI. Overall, the findings indicate that both financial perceptions and pro-social attitudes are connected to consumer investment in SRI. (shrink)

The traditional square of opposition is generalized and extended to a cube of opposition covering and conveniently visualizing inter-sentential oppositions in relational syllogistic logic with the usual syllogistic logic sentences obtained as special cases. The cube comes about by considering Frege–Russell’s quantifier predicate logic with one relation comprising categorical syllogistic sentence forms. The relationships to Buridan’s octagon, to Aristotelian modal logic, and to Klein’s 4-group are discussed.GraphicThe photo shows a prototype sculpture for the cube.

The topic of this study is to what extent standards of rational inquiry can be rationally criticized and revised. It is argued that it is rational to treat all such standards as open to criticism and revision. Arguments to the effect that we are fallible with regard to all standards of rational inquiry are presented. Standards cannot be ultimately justified and with certainty established either as adequate or as inescapable presuppositions. Apel's attempt to give ultimate justifications of certain moral and (...) logical rules is examined and criticized. Special attention is given to our fallibility with regard to logical inference rules. The idea that certain logical rules cannot be put into question because any critical argument presupposes them is criticized. It has been claimed that there must be some basic standards which are such that they cannot be rationally evaluated and hence are rationally unrevisable. This is called "the unrevisability thesis". Related to this thesis is the normative policy according to which rationality requires that some standards be treated as unrevisable, the unrevisability policy. Two arguments that have been used to defend the unrevisability thesis and policy are examined and criticized. The conclusion is that we are not forced to accept either the thesis or the policy. The negation of the unrevisability policy is the revisability policy, according to which it is rational to treat all standards as open to rational criticism and revision. Objections that have been directed against the revisability policy are discussed and criticized. According to the objections, the revisability policy leads to rationality relativism. These objections are refuted, and it is argued that it is, on the contrary, rational to adopt the revisability policy and treat all standards of rational inquiry as criticizable and revisable. It is proposed that the rational change of standards should be viewed as a bootstrap process. General features of a bootstrap view of rational change of standards are presented, and it is argued that it is impossible to formulate a real theory of bootstrapping. Two models of standard change are presented and discussed: Laudan's reticulated model of scientific rationality and Briskman's bootstrap theory. It is claimed that in spite of defects and limitations, these models contribute to a richer understanding of bootstrapping. The fallibility and revisability of standards of rational inquiry have consequences for how the normativity of rationality should be understood. The book ends with an account of how the rationality of cognitive actions is related to the idea of the adequacy of standards. A distinction between absolute and standard-relative rationality is made, and it is argued that what an inquiring agent rationally ought to do coincides with what it is standard-relatively rational for him to do. It is shown that this view of rationality of inquiry is nevertheless inconsistent with rationality relativism, and that it is compatible with an objectivistic view of rationality. (shrink)

This article explores the idea of film as a possible means for articulating original philosophical concepts, in Gilles Deleuze’s sense of concepts. The first of two parts, critically re-examines current ideas about film as philosophy in relation to Deleuze’s ideas on philosophy and cinema/art. It is common within the field of film-philosophy to trace back its central argument that film/cinema is capable of expressing original philosophy, to Deleuze’s cinema books. In and around these books, however, Deleuze did not express such (...) an idea and rather underlined sharp formal differences between cinematic thinking and philosophy. Cinematic thinking takes the form, he argues, of blocks of movement/duration whereas philosophy is defined as the art of creating concepts. Still, could a close critical scrutiny of and some creativity with Deleuze’s thought allow for taking a step he did not take? The second part of the article takes on the speculative question of whether it is possible to create a notion from within Deleuze’s thought as a whole, that allows for at least the theoretical possibility of articulating original philosophical concepts – as Deleuze defines them – in and through film, and what this would mean for our understanding of the concrete form of concepts. The article examines Deleuze’s concept of concepts, his descriptions of complicating intersections between philosophy and art, some partly conflicting statements on Godard over the years, aspects of his analyses of filmic thinking in Cinema 2 that can be seen to provide preliminary components for articulating concepts in and through film, and it discusses the place and function of words and texts in such filmic articulations. If the aim of the first part is to clarify Deleuze’s positions on film and philosophy the aim of the second part resonates with the Deleuzian/Nietzschean quest for formal renewal of philosophy. The overall aim is to re-problematize and provide subtle new means for conceiving of and discussing the notion of film as philosophy. (shrink)

Segregation of chromosomes during mitosis requires the interaction of dynamic microtubules with the kinetochore, a large protein structure established on the centromere region of sister chromatids. The core microtubule‐binding activity of the kinetochore resides in the KMN network, an outer kinetochore complex. As part of the KMN network, the Ndc80 complex, which is composed of Ndc80, Nuf2, Spc24, and Spc25, is able to bind directly to microtubules and has the ability to track with depolymerizing microtubules to produce chromosome movement. The (...) Ndc80 complex binds directly to microtubules through a calponin homology domain and an unstructured tail in the N terminus of the Ndc80 protein. A recent flurry of papers has highlighted the importance of an internal loop region in Ndc80 in establishing end‐on attachment to microtubules. Here I discuss these recent findings that suggest that the Ndc80 internal loop functions as a binding site for proteins required for kinetochore‐microtubule interactions. (shrink)

The fate of cells arrested in mitosis by antimitotic compounds is complex but is influenced by competition between pathways promoting cell death and pathways promoting mitotic exit. As components of both of these pathways are regulated by Cdc20‐dependent degradation, I hypothesize that variations in Cdc20 protein levels, rather than mutations in checkpoint genes, could affect cell fate during prolonged mitotic arrest. This hypothesis is supported by experiments where manipulation of Cdc20 levels affects the response to antimitotic compounds. The observed differences (...) in Cdc20 levels between cell lines likely reflects differences in the rate of synthesis or degradation of the protein; therefore, understanding these pathways at a molecular level could pave the way for modulating the activity of Cdc20, in turn presenting novel therapeutic possibilities. (shrink)

The metaverse is equivocal. It is a science-fictional concept from the past; it is the present’s rough implementations; and it is the Promised Cyberland, expected to manifest some time in the future. The metaverse first emerged as a techno-capitalist network in a 1992 science fiction novel by Neal Stephenson. Our article thus marks the metaverse’s thirtieth anniversary. We revisit Stephenson’s original concept plus three sophisticated antecedents from 1972 to 1984: Jean Baudrillard’s simulation, Sherry Turkle’s networked identities, and Jacques Lacan’s schema (...) of suggestible consumers hooked up to a Matrix-like capitalist network. We gauge the relevance of these three antecedents following Meta’s recent promise to deliver a metaverse for the mainstream and the emergence of blockchain-oriented metaverse projects. We examine empirical data from 2021 and 2022, sourced from journalistic and social media (BuzzSumo, Google Trends, Reddit, and Twitter) as well as the United States Patent and Trademark Office. This latest chapter of the metaverse’s convoluted history reveals a focus not on virtual reality goggles but rather on techno-capitalist notions like digital wallets, crypto-assets, and targeted advertisements. The metaverse’s wallet-holders collect status symbols like limited-edition profile pictures, fashion items for avatars, tradable pets and companions, and real estate. Motivated by the metaverse’s sophisticated antecedents and our empirical findings, we propose a subtle conceptual re-orientation that respects the metaverse’s equivocal nature and rejects sanitised solutionism. Do not let the phantasmagorical goggles distract you too much: Big Meta is watching you, and it expects you to become a wallet-holder. Blockchain proponents want this as well. (shrink)

In this paper a bootstrap theory of rationality is presented. Such a theory is an attempt to explain how standards of rational inquiry may be rationally revised — without assuming that there are any basic and fixed standards for evaluating such revisions. The general bootstrap idea is briefly presented in the first sections. The main part of the paper consists of a discussion of what normative requirements a bootstrap theory should contain, and a number of requirements on rational revisions are (...) proposed. The final section deals with the question of whether a bootstrap theory is self-referentially coherent. (shrink)

A central aim for philosophers of science has been to understand scientific theory change, or more specifically the rationality of theory change. Philosophers and historians of science have suggested that not only theories but also scientific methods and standards of rational inquiry have changed through the history of science. The topic here is methodological change, and what kind of theory of rational methodological change is appropriate. The modest ambition of this paper is to discuss in what ways results in formal (...) theories of belief revision can throw light on the question of what an appropriate theory of methodological change would look like. (shrink)

Early embryogenesis is marked by a frail Spindle Assembly Checkpoint (SAC). The time of SAC acquisition varies depending on the species, cell size or a yet to be uncovered developmental timer. This means that for a specific number of divisions, biorientation of sister chromatids occurs unsupervised. When error‐prone segregation is an issue, an aneuploidy‐selective apoptosis system can come into play to eliminate chromosomally unbalanced cells resulting in healthy newborns. However, aneuploidy content can be too great to overcome, endangering viability.SAC generates (...) a diffusible signal to lengthen time spent in mitosis if needed, ensuring correct chromosome segregation, a fundamental factor in the generation of euploid cells. Thus, it remains puzzling what benefit could come from delaying SAC acquisition till later in the development. In this review, we describe what is known on SAC acquisition in distinct species and highlight pending research as well as potential applications for such knowledge. (shrink)