The Anthropic Principle, in use by physicists, astronomers, and cosmologists, is currently under consideration by philosophers. This principle, in its various forms, appeals to man's existence as a constraint on our determination of natural laws and natural constants, as a principle of prediction, and, in its strongest form, as a principle of explanation which sanctions an argument for the universe being a product of design. What I shall endeavour to show here is how this principle, in its various forms, is (...) used in furthering our understanding of cosmology, and why this principle cannot be used as a principle of explanation. (shrink)

The immune surveillance theory postulates that spontaneous tumors are normally rejected by the immune system and appear only when they override host‐immune recognition and rejection mechanisms. The present mini‐review describes a spontaneous tumor system, the reticulum cell sarcomas (RCS) in SJL/J mice, that is dependent on host tumor‐specific immune lymphocytes for growth. This continuous tumor‐specific response results in tumor progression and death of the host. This tumor system contradicts the basic concept of immune surveillance. We propose as an explanation that (...) some highly antigenic tumors, like the RCS, may have evolved in a non‐autonomous fashion but, nevertheless, have lost regulatory controls of cell proliferation. In the RCS system, the tumor expresses Class II MHC I‐E like specificities that are not expressed on the host cells and which selectively stimulate a subpopulation of I‐E specific T cells, the Vβ17a+ clonotype, leading to their expansion and continuous nurturing of the tumor via secreted lymphokines. This neoantigenic stimulation bypasses the tumor regulatory response that might have resulted if the tumor had not expressed neo‐antigens. Furthermore, passive administration of anti‐clonotypic antibody to tumor‐bearing mice results in tumor regression and long‐term survival through removal of the tumor reactive T cells. Thus, in this tumor system, immunosuppressive treatments are the prescription for tumor rejection. (shrink)

According to the jacket cover, John Leslie's Universes is “the first book by a philosopher on these controversial affairs.” Sadly, I must report, the controversy has gotten the better of his philosophy. Leslie's contribution to this area is merely to see, within the dispute, a narrow window through which to promote his own curious view of extreme axiarchism. This alone would not disturb me, were it not for the apparent disdain with which Leslie depicts views opposed to his own, and (...) his infuriating technique of responding to those critics who fail to see the point of his tremendously contrived examples by dogmatically waving these same examples. (shrink)

The study of philosophy has no leading edge. Scholars may fruitfully explore past eras and superceded theories, revise their views of historic figures, modify inadequate theories, defend successful yet overlooked ideas, salvage the wheat from the chaff. A novel defense of previously discredited arguments could lead to new insights, and this is so even if that defense proved ultimately unsuccessful. But, I believe, one can profitably defend some perhaps too hastily condemned view only if one meanwhile keeps a watchful eye (...) on contemporary problems and theorizing. Fred Wilson's monograph, Explanation, Causation and Deduction, attempts just such a defense, while steadfastly ignoring much of contemporary theory. The lack of a sympathetic ear to recent critics of empiricism is the largest single failing of this attempt, and it is this failing which has prevented Prof. Wilson from seeing the poverty of his position. (shrink)