Nerve processes elongate, branch and form synaptic contacts in a highly regulated and specific manner. Long‐distance axon elongation is restricted to the main phase of axon formation during development, but can be reinduced upon lesions in the adult (regeneration). It correlates with the expression of defined genes, including proteins involved in signalling (e.g. src, NCAM, integrins), transcription factors (e.g. c‐jun) and structural proteins (e.g. actin and tubulin isoforms). Activation of an axon elongation program may require bcl‐2. The formation and growth (...) of local branches (sprouting) is controlled by mechanisms in the target region. In addition, the expression of growth‐associated proteins such as GAP‐43 and CAP‐23 in neurons lowers the threshold for nerve sprouting and potentiates its vigour. Recent studies suggest that nerve sprouting and long‐distance elongation depend on the expression of different intrinsic components in neurons. One implication of these findings is that the differential expression of genes facilitating local branching may affect structural plasticity in the intact adult nervous system. (shrink)

An analysis of Nicholas of Cusa’s conception of the power of judgment that shows it enables morality as well as cognition.

Para las empresas recolectoras de residuos sólidos es indispensable controlar los factores de riesgos asociados a la calidad del aire del entorno laboral de sus empleados con el objetivo de minimizar las afecciones de salud de sus trabajadores. El propósito del estudio es desarrollar un prototipo de un sensor inalámbrico de medición de calidad de aire. Este instrumento de medición será implementado en ambientes laborales para trabajadores de recolección de residuos sólidos. A partir del estudio se concluye que para empresas (...) de este sector es indispensable el control de factores de riesgos asociados a la exposición a gases y vapores. (shrink)

An ardent treatise for the Dignity of Man, which elevates Humanism to a truly Christian level, making this writing as pertinent today as it was in the Fifteenth Century.

To początkowy fragment mowy O godności człowieka Pico della Mirandoli." Wstępem poprzedział Danilo Facca, przełożyli Zbigniew Nerczuk i Mikołaj Olszewski. -/- This is an excerpt from the Polish translation of Pico della Mirandola's De dignitate hominis. The preface to the translation by Danilo Facca. Translation by Zbigniew Nerczuk and Mikołaj Olszewski.

Ziel dieser kleinen, 1492 abgefaßten und für das Verständnis der Renaissancephilosophie bedeutsamen Schrift ist der Nachweis der Vereinbarkeit der Grundlehren der platonischen und der aristotelischen Metaphysik, also die Herbeiführung der Entscheidung in einer zwischen den Neuplatonikern seiner Zeit und den Peripatetikern ausgetragenen Kontroverse, mit denen Pico in engem Kontakt stand. Der Traktat basiert auf der späteren kritischen Auseinandersetzung Picos mit seinem ehemaligen Lehrer Ficino und einer 1490 geführten, sehr intensiven Diskussion mit den beiden anderen.

This is a translation of three works by Mirandola: "On the Dignity of Man," a document of early Renaissance humanism; "One Being and the One," a treatise on the relationship between unity and being; and "Heptaplus," an interpretation of the first verses of "Genesis.".

This volume contains Gianfrancesco Pico's Life of his uncle Giovanni Pico and also Giovanni's Oration. Gianfrancesco's Life opens a collection that omits Giovanni's Conclusions but includes the speech that we - unlike Pico - know as an Oration on the Dignity of Man. He wrote the Oration to introduce the Conclusions, but his nephew's editorial decision cut the theses off from the speech that their author had connected with them. Several times in the Oration, the orator mentioned (...) "theorems" to be proposed in the Conclusions: he clearly saw the book and the speech as tools for the same task. Either Gianfrancesco missed his uncle's intentions, which seems unlikely, or he meant to seal off his other writings - including the Oration - from a book that he found embarrassing for himself and his relative and too risky to make public. This is the fact of the matter: Gianfrancesco left the Conclusions unpublished while publishing the Oration in a collection introduced by his Life. Both the speech and the biography are presented here, in this edition, in the same way - apart from the Conclusions: this reflects the situation in 1496 and respects Gianfrancesco's choice, even though his decision blocked understanding of the speech for many years. Today, with access to all the relevant texts in many versions, readers can move from one work to another as needed. (shrink)

We propose here the first translation into Portuguese of Giovanni Pico della Mirandola’s small treatise De Ente et Uno (1491). The translation is preceded by a brief presentation in which the work is contextualized within the scope of the thought of its young author and in the Florentine philosophical environment of the end of the Quattrocento. In the aftermath of the controversies between defenders of Plato and defenders of Aristotle, a quarrel brought by Greek and Byzantine intellectuals into Italy, (...) who exacerbated the differences between the two philosophers, there were also others who tried to show the essential concord between them, a purpose of which Pico’s treatise is one of the most expressive and relevant documents, seeking to prove the equivalence between Plato’s One and Aristotle’s Being. (shrink)

In this study, we explore the relation between scientific literacy and unwarranted beliefs. The results show heterogeneous interactions between six constructs: conspiracy theories poorly interact with scientific literacy; there are major differences between attitudinal and practical dimensions of critical thinking; paranormal and pseudoscientific beliefs show similar associations ; and, only scientific knowledge interacts with other predictor of unwarranted beliefs, such as ontological confusions. These results reveal a limited impact: science educators must take into account the complex interactions between the dimensions (...) of scientific literacy and different types of unwarranted beliefs to improve pedagogical strategies. (shrink)

Discourse on the dignity of humanity by Giovanni Pico della Mirandola, a renaissance Italian prince known for his erudition and sensitivity.

Reflecting the broad range of interests of a major Renaissance philosopher and his distinctive brand of syncretism, this anthology offers in their entirety three central works of Pico's. _On the Dignity of Man,_ the quintessential expression of Renaissance humanism, appears in the context of two lesser known but equally representative mature works: _On Being and the One_, a treatise defending what Pico held to be the agreement between Aristotle and Plato on the relation between unity and being, and (...) _Heptaplus_, an interpretation, influenced by a blend of cabalism and Christian doctrine, of the first verses of Genesis. New Selected Bibliography. (shrink)

El artículo aborda la responsabilidad médica penal por omisión en situaciones de emergencia de salud, debido a las dudas que aún existen sobre el accionar médico en estas circunstancias y las posibles consecuencias jurídicas por negligencia, impericia e imprudencia. La responsabilidad médica incluye la obligación moral de responder de los propios actos y reparar o indemnizar las consecuencias perjudiciales para terceros. Se identifican las falencias en las normativas ecuatorianas con relación al actuar médico en situaciones de emergencia de salud y (...) se busca aportar a la academia con publicaciones de conocimiento. Se analizan los elementos normativos y fácticos de la responsabilidad médica penal por omisión en situaciones de emergencia de salud en la República de Ecuador, y se busca identificar el marco normativo en la legislación ecuatoriana para superar la inadecuada actuación médica en estas situaciones. El conocimiento de la normativa legal contribuye a superar la responsabilidad médica penal por omisión en situaciones de emergencia en el Ecuador y se menciona y se analiza el art.146 del COIP que es la normativa vigente. El artículo concluye que el objetivo no es criminalizar la práctica médica, ya que no toda muerte es homicidio y no todo proceso judicial implica el encarcelamiento de los involucrados. (shrink)

In the framework of the commemoration of the Bicentennial of the Independence of Colombia and, using the method of historical prosopography, this article aims to analyze the contribution of the Franciscan Father Francisco Antonio Florido as a social and political actor in the process of consolidation of the Bases of the republican project through three specific facets in its role as chaplain in the military campaigns, in its protagonism in the political celebrations and in the promotion to the education. It (...) really surprises him how he broke with the entrenched ideological scheme that had linked the ecclesiastical estate with the Spanish monarchy, and became one of the most staunch defenders of the Free Fatherland with a progressive and modern thinking. A verification of the contribution of the ecclesiastical establishment to the process of formation of the Republic. (shrink)

t. 1. Scripta in editione Basilensi anno MDLXXII collecta.-- t. 2. Rime, Carmina, Commentaria in psalmos, Epistolae; Appendix; I. Reuchlin, De arte cabalistica.

Famous debate between E. Barbaro and G. Pico della Mirandola in 1485 concerning humanism and scholasticism and the role of rhetoric.

t. 1. Scripta in editione Basilensi anno 1573 collecta. 2 v.

En muchos de los refranes y comportamientos de los colombianos son identificables códigos e interacciones heredadas, en las que se acostumbra al ciudadano a formar parte de un sistema en el que se prolifera la corrupción social. Para equilibrar la balanza ante la necesidad de justicia, se utilizan sistemas sancionatorios, los cuales son también susceptibles de corrupción; es aquí donde, a partir de la reflexión en torno a la cultura y la educación, se propone el trabajo principalmente de la familia (...) y la escuela en la búsqueda de herramientas de prevención de todo tipo de corrupción, que permitan el desarrollo de una sociedad en la que prime la formación valores en la niñez y la adolescencia. (shrink)

Diese Ausgabe bietet erstmals einen Schlüsseltext für die Reformation der Metaphysik in der Philosophie der Renaissance in deutscher Übersetzung. Der lateinische Text ist beigegeben. Die ausführliche Einleitung und ein sorgfältiger Kommentar erschließen die richtunggebenden Pointen, die Pico mit dieser Schrift gesetzt hat.