Vacuolar ATPases (V‐ATPases, V1Vo‐ATPases) are rotary motor proton pumps that acidify intracellular compartments, and, when localized to the plasma membrane, the extracellular space. V‐ATPase is regulated by a unique process referred to as reversible disassembly, wherein V1‐ATPase disengages from Vo proton channel in response to diverse environmental signals. Whereas the disassembly step of this process is ATP dependent, the (re)assembly step is not, but requires the action of a heterotrimeric chaperone referred to as the RAVE complex. Recently, an alternative pathway (...) of holoenzyme disassembly was discovered that involves binding of Oxidation Resistance 1 (Oxr1p), a poorly characterized protein implicated in oxidative stress response. Unlike conventional reversible disassembly, which depends on enzyme activity, Oxr1p induced dissociation can occur in absence of ATP. Yeast Oxr1p belongs to the family of TLDc domain containing proteins that are conserved from yeast to mammals, and have been implicated in V‐ATPase function in a variety of tissues. This brief perspective summarizes what we know about the molecular mechanisms governing both reversible (ATP dependent) and Oxr1p driven (ATP independent) V‐ATPase dissociation into autoinhibited V1 and Vo subcomplexes. (shrink)

From Socrates and the Sophists to Kant, from Augustine to Aquinas and the Reformers, Colin Brown traces the turbulent, often tension-filled, always fascinating story of the thinkers, ideas and movements that have shaped our intellectual landscape. Is philosophy the "handmaiden of faith" or "the doctrine of demons"? Does it clarify the faith or undermine the very heart of Christian belief?Brown writes, "This book is about the changes in preconceptions, world views and paradigms that have affected the ways in which people (...) have thought about religion in general and Christianity in particular in the Western world.... It is a historical sketch, written to help students--and anyone else who might be interested--to get a better grasp of the love-hate relationship between philosophy and faith that has gone on for close to two thousand years."Students, pastors and thoughtful Christians will benefit from this rich resource. The first in a proposed three-volume work, Brown's easy-to-read, hard-to-put-down introduction to Christianity and Western thought focuses on developments from the ancient world to the Age of Enlightenment. (shrink)

Steve Wilkens edits a conversation between four major approaches to contemporary ethics in the Christian tradition: virtue, divine command, natural law, and prophetic. This accessible introduction includes contributions by Brad Kallenberg, John Hare, Claire Peterson, and Peter Heltzel.

Steve Wilkens edits a debate between three different understandings of the relationship between faith and reason, between theology and philosophy. The three views include: Faith and Philosophy in Tension, Faith Seeking Understanding and the Thomistic Synthesis. This introduction to a timeless quandary is an essential resource for students.

Building on the work of worldview thinkers like James Sire, this book helps those committed to the gospel story recognize those rival cultural stories that ...

Die klassische Basis des Bewusstseins ist unzureichend, um seine gesamte Spannbreite zu erfassen: das Gruppenbewusstsein auf der natürlichen Basis der Energie, das Wir-Subjekt und das Historische Subjekt. Die sich ergebenden Beziehungen sind vor allem polar zu begreifen, ihre Logik entfaltet sich bis in das Problem der modernen Antinomien.

Introduction to Philosophy: Christianity and the Big Questions is a perfect primer for students of philosophy and anyone interested in a Christian perspective on the timeless and universal perplexities of human existence.--Thomas M. Crisp, Professor of Philosophy, Biola University.

Die Kategorienlehre Kants verlangt eine Determination der Anschauung durch das Verstandesvermögen als Subordination. Ihre Umkehrung ermöglicht die Analyse der Erkenntnisformen durch bestimmte Fakultätenverhältnisse. Die Projektion ist ein Zeuge und Beweismittel, das der Korrespondenz den Rücken stärkt und den Mythos des Gegebenen abweist.

Der Beitrag untersucht anhand von Romanen des 17. und 18. Jahrhunderts das formale Motiv der gleichzeitigen Hochzeit vieler Paare am Romanschluss und seine strukturellen Implikationen. Bereits im 17. Jahrhundert lassen sich in den wichtigsten französischen und deutschen hohen Barockromanen erhebliche autorspezifische Variationen bei der Darstellung der Schlussordnung aufzeigen. Die Rekonstruktion der Ordnung sämtlicher Liebeshandlungen der Römischen Octavia des Herzogs Anton Ulrich klärt über die Diskrepanz von finaler Repräsentation und den im Textverlauf gültigen Bestimmungen auf. Im 18. Jahrhundert kommt es zu (...) einer Umfunktionalisierung des Motivs: im Sinne einer Dynamisierung und rhythmischen Verfeinerung der parallelen Führung nun einander immer ähnlicher werdender Liebeshandlungen; und im Sinne der Ausstellung formaler Virtuosität. (shrink)