As evidenced by high-throughput sequencers, genomic technologies have recently undergone radical advances. These technologies enable comprehensive sequencing of personal genomes considerably more efficiently and less expensively than heretofore. These developments present a challenge to the conventional framework of biomedical ethics; under these changing circumstances, each research project has to develop a pragmatic research policy. Based on the experience with a new large-scale project—the Genome Science Project—this article presents a novel approach to conducting a specific policy for personal genome research in (...) the Japanese context. In creating an original informed-consent form template for the project, we present a two-tiered process: making the draft of the template following an analysis of national and international policies; refining the draft template in conjunction with genome project researchers for practical application. Through practical use of the template, we have gained valuable experience in addressing challenges in the ethical review process, such as the importance of sharing details of the latest developments in genomics with members of research ethics committees. We discuss certain limitations of the conventional concept of informed consent and its governance system and suggest the potential of an alternative process using information technology. (shrink)

_BMC Medical Ethics_ is an open access journal publishing original peer-reviewed research articles in relation to the ethical aspects of biomedical research and clinical practice, including professional choices and conduct, medical technologies, healthcare systems and health policies. _BMC __Medical Ethics _is part of the _BMC_ series which publishes subject-specific journals focused on the needs of individual research communities across all areas of biology and medicine. We do not make editorial decisions on the basis of the interest of a study or (...) its likely impact. Studies must be scientifically valid; for research articles this includes a scientifically sound research question, the use of suitable methods and analysis, and following community-agreed standards relevant to the research field. Specific criteria for other article types can be found in the submission guidelines. _BMC series - open, inclusive and trusted_. (shrink)

As in other countries, the traditional doctor-patient relationship in the Japanese healthcare system has often been characterised as being of a paternalistic nature. However, in recent years there has been a gradual shift towards a more participatory-patient model in Japan. With advances in technology, the possibility to use digital technologies to improve patient interactions is growing and is in line with changing attitudes in the medical profession and society within Japan and elsewhere. The implementation of an online patient engagement platform (...) is being considered by the Myotonic Dystrophy Registry of Japan. The aim of this exploratory study was to understand patients’ views and attitudes to using digital tools in patient registries and engagement with medical research in Japan, prior to implementation of the digital platform. We conducted an exploratory, cross-sectional, self-completed questionnaire with a sample of myotonic dystrophy patients attending an Open Day at Osaka University, Japan. Patients were eligible for inclusion if they were 18 years or older, and were diagnosed with MD. A total of 68 patients and family members attended the Open Day and were invited to participate in the survey. Of those, 59 % submitted a completed questionnaire. The survey showed that the majority of patients felt that they were not receiving the information they wanted from their clinicians, which included recent medical research findings and opportunities to participate in clinical trials, and 88 % of patients indicated they would be willing to engage with digital technologies to receive relevant medical information. Patients also expressed an interest in having control over when and how they received this information, as well as being informed of how their data is used and shared with other researchers. Overall, the findings from this study suggest that there is scope to develop a digital platform to engage with patients so that they can receive information about medical care and research opportunities. While this study group is a small, self-selecting population, who suffer from a particular condition, the results suggest that there are interested populations within Japan that would appreciate enhanced communication and interaction with healthcare teams. (shrink)

Given an intermediate prepositional logic L, denote by L –d its disjuctionless fragment. We introduce an infinite sequence {J n}n1 of propositional formulas, and prove:(1)For any L: L –d =I –d (I=intuitionistic logic) if and only if J n L for every n 1.

LetSKP be the intermediate prepositional logic obtained by adding toI (intuitionistic p.l.) the axiom schemes:S = (( ) ) (Scott), andKP = ()()() (Kreisel-Putnam). Using Kripke's semantics, we prove:1) SKP has the finite model property; 2) SKP has the disjunction property. In the last section of the paper we give some results about Scott's logic S = I+S.

The paper settles an open question concerning Negri-style labeled sequent calculi for modal logics and also, indirectly, other proof systems which make (more or less) explicit use of semantic parameters in the syntax and are thus subsumed by labeled calculi, like Brünnler’s deep sequent calculi, Poggiolesi’s tree-hypersequent calculi and Fitting’s prefixed tableau systems. Specifically, the main result we prove (through a semantic argument) is that labeled calculi for the modal logics K and D remain complete w.r.t. valid sequents whose relational (...) part encodes a tree-like structure, when the unique rule which contains an harmful implicit contraction—by which the condition that the premises be less complex than the conclusion is violated—is modified into a contraction-free one respecting the latter condition, thus making the proof-search space finite. (shrink)

We aim at clarifying to what extent the work of the English mathematician George Boole on the algebra of logic is taken into consideration and discussed in the work of early Husserl, focusing in particular on Husserl’s lecture “Über die neueren Forschungen zur deduktiven Logik” of 1895, in which an entire section is devoted to Boole. We confront Husserl’s representation of the problem-solving processes with the analysis of “symbolic reasoning” proposed by George Boole in the Laws of Thought and try (...) to show how and why Husserl, while praising Boole’s calculus, strongly criticizes his attempt at a philosophical clarification and justification of it. (shrink)

We introduce, in a general setting, an ‘‘analytic’’ version of standard equational calculi of combinatory logic. Analyticity lies on the one side in the fact that these calculi are characterized by the presence of combinatory introduction rules in place of combinatory axioms, and on the other side in that the transitivity rule proves to be eliminable. Apart from consistency, which follows immediately, we discuss other almost direct consequences of analyticity and the main transitivity elimination theorem; in particular the Church−Rosser and (...) the leftmostreduction theorems for the associated notions of reduction. The last two sections deal with analytic combinatory calculi with the extensionality rule added. Here, as far as the elimination of transitivity is concerned, we have only partial results, which unfortunately do not cover, at present, full CL + Ext. Yet, they are sufficient to prove the decidability of weaker combinatory calculi with extensionality, including e.g. BCK + Ext. (shrink)

For each ordinal $\alpha > 0, L(\alpha)$ is the intermediate predicate logic characterized by the class of all Kripke frames with the poset α and with constant domain. This paper will be devoted to a study of logics of the form L(α). It will be shown that for each uncountable ordinal of the form α + η with a finite or a countable $\eta (> 0)$ , there exists a countable ordinal of the form β + η such that L(α (...) + η) = L(β + η). On the other hand, such a reduction of ordinals to countable ones is impossible for a logic L(α) if α is an uncountable regular ordinal. Moreover, it will be proved that the mapping L is injective if it is restricted to ordinals less than ω ω , i.e. α ≠ β implies L(α) ≠ L(β) for each ordinal $\alpha,\beta. (shrink)

It has often been remarked that the metatheory of strong reduction $\succ$ , the combinatory analogue of βη-reduction ${\twoheadrightarrow_{\beta\eta}}$ in λ-calculus, is rather complicated. In particular, although the confluence of $\succ$ is an easy consequence of ${\twoheadrightarrow_{\beta\eta}}$ being confluent, no direct proof of this fact is known. Curry and Hindley’s problem, dating back to 1958, asks for a self-contained proof of the confluence of $\succ$ , one which makes no detour through λ-calculus. We answer positively to this question, by extending (...) and exploiting the technique of transitivity elimination for ‘analytic’ combinatory proof systems, which has been introduced in previous papers of ours. Indeed, a very short proof of the confluence of $\succ$ immediately follows from the main result of the present paper, namely that a certain analytic proof system G e [ $\mathbb {C}$ ] , which is equivalent to the standard proof system CL ext of Combinatory Logic with extensionality, admits effective transitivity elimination. In turn, the proof of transitivity elimination—which, by the way, we are able to provide not only for G e [ $\mathbb {C}$ ] but also, in full generality, for arbitrary analytic combinatory systems with extensionality—employs purely proof-theoretical techniques, and is entirely contained within the theory of combinators. (shrink)

We give completeness results — with respect to Kripke's semantic — for the negation-free intermediate predicate calculi.

We aim at clarifying to what extent the work of the German mathematician Ernst Schröder on the algebra of logic is taken into consideration and rehashed in the work of the early Husserl, focusing on Husserl’s 1891 Review of the first volume of Schröder’s monumental Vorlesungen über die Algebra der Logik and on Husserl’s text Der Folgerungskalkül und die Inhaltslogik written in the same year. We will try to show how and why Husserl, while praising Schröder’s calculus, strongly criticizes Schröder’s (...) attempt at a philosophical clarification and justification of it. (shrink)

This paper deals with the infinitary modal propositional logic Kω1, featuring countable disjunctions and conjunc- tions. It is known that the natural infinitary extension LK.

We introduce a certain extension of -calculus, and show that it has the Church-Rosser property. The associated open-term extensional combinatory algebra is used as a basis to construct models for theories of Explict Mathematics (formulated in the language of "types and names") with positive stratified comprehension. In such models, types are interpreted as collections of solutions (of terms) w.r. to a set of numerals. Exploiting extensionality, we prove some consistency results for special ontological axioms which are refutable under elementary comprehension.

We deal with ontological problems concerning basic systems of explicit mathematics, as formalized in Jäger's language of types and names. We prove a generalized inseparability lemma, which implies a form of Rice's theorem for types and a refutation of the strong power type axiom POW + . Next, we show that POW + can already be refuted on the basis of a weak uniform comprehension without complementation, and we present suitable optimal refinements of the remaining results within the weaker theory.

The IOth International Congress of Logic, Methodology and Philosophy of Science, which took place in Florence in August 1995, offered a vivid and comprehensive picture of the present state of research in all directions of Logic and Philosophy of Science. The final program counted 51 invited lectures and around 700 contributed papers, distributed in 15 sections. Following the tradition of previous LMPS-meetings, some authors, whose papers aroused particular interest, were invited to submit their works for publication in a collection of (...) selected contributed papers. Due to the large number of interesting contributions, it was decided to split the collection into two distinct volumes: one covering the areas of Logic, Foundations of Mathematics and Computer Science, the other focusing on the general Philosophy of Science and the Foundations of Physics. As a leading choice criterion for the present volume, we tried to combine papers containing relevant technical results in pure and applied logic with papers devoted to conceptual analyses, deeply rooted in advanced present-day research. After all, we believe this is part of the genuine spirit underlying the whole enterprise of LMPS studies. (shrink)

We deal with ontological problems concerning basic systems of explicit mathematics, as formalized in Jager's language of types and names. We prove a generalized inseparability lemma, which implies a form of Rice's theorem for types and a refutation of the strong power type axiom POW$^+$. Next, we show that POW$^+$ can already be refuted on the basis of a weak uniform comprehension without complementation, and we present suitable optimal refinements of the remaining results within the weaker theory.

We introduce new proof systems G[β] and G ext[β], which are equivalent to the standard equational calculi of λβ- and λβη- conversion, and which may be qualified as ‘analytic’ because it is possible to establish, by purely proof-theoretical methods, that in both of them the transitivity rule admits effective elimination. This key feature, besides its intrinsic conceptual significance, turns out to provide a common logical background to new and comparatively simple demonstrations—rooted in nice proof-theoretical properties of transitivity-free derivations—of a number (...) of well-known and central results concerning β- and βη-reduction. The latter include the Church–Rosser theorem for both reductions, the Standardization theorem for β- reduction, as well as the Normalization (Leftmost reduction) theorem and the Postponement of η-reduction theorem for βη-reduction. (shrink)

We show that there is a purely proof-theoretic proof of the Rasiowa–Harrop disjunction property for the full intuitionistic propositional calculus ), via natural deduction, in which commuting conversions are not needed. Such proof is based on a sound and faithful embedding of \ into an atomic polymorphic system. This result strengthens a homologous result for the disjunction property of \ and answers a question then posed by Pierluigi Minari.

The Placidus Glossary was hailed in Ritschl's time as a new clue to Plautus' true text. And Buecheler, Ritschl's pupil, seized on its Alapari est alapas minari, etc., and foisted this verb on Plaut. True. 928. The great Latin Thesaurus quotes the line with this piece of new cloth put on an old garment: nil alapari satiust, miles, instead of the correct philippiari satiust, miles.